Long-Term Evaluation of Post-transplant Lymphoproliferative Disorders in Paediatric Heart Transplantation in Sao Paulo, Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorARSHAD, Adam
dc.contributor.authorAZEKA, Estela
dc.contributor.authorBARBAR, Samia
dc.contributor.authorMARCONDES, Raphael
dc.contributor.authorSIQUEIRA, Adailson
dc.contributor.authorBENVENUTI, Luiz
dc.contributor.authorMIURA, Nana
dc.contributor.authorJATENE, Marcelo
dc.contributor.authorODONE FILHO, Vicente
dc.date.accessioned2020-01-21T14:55:48Z
dc.date.available2020-01-21T14:55:48Z
dc.date.issued2019
dc.description.abstractWe sought to better define the demographics and characteristics of post-transplant lymphoproliferative disorders (PTLD) in a cohort of paediatric OHT patients from a developing country. Data were collected from the Heart Institute, Sao Paulo, for all paediatric OHT recipients from October 1992 to October 2018. Group differences between the PTLD and non-PTLD cohorts were assessed by Fisher exact and Mann-Whitney U tests. Kaplan-Meier curves analysed the survival in each group. Data were reviewed for 202 paediatric OHT recipients. Overall 1-, 5- and 10-year survival for the entire cohort was 76.5%, 68.3% and 62.9%; 24 patients (11.9%) developed PTLD at a median 3.1 years (IQR 0.8-9.0) after OHT. Cases were evenly spread over the follow-up period, with PTLD diagnosed in 9.8% (n = 137) of patients who were alive at 3 years, 15.3% (n = 78) of patients who were alive at 5 years and 29.3% (n = 41) of patients who were alive at 10 years. The commonest form of PTLD was diffuse large B cell lymphoma (n = 9), and most patients received rituximab with immunosuppression and chemotherapy as treatment (n = 15). We identified no increased risk in mortality amongst the PTLD vs. non-PTLD cohorts in multivariate analysis (P = 0.365). PTLD after paediatric OHT had acceptable outcomes. However, risk factors for PTLD were not identified and warrant further investigation.eng
dc.description.indexMEDLINEeng
dc.identifier.citationPEDIATRIC CARDIOLOGY, v.40, n.8, p.1655-1662, 2019
dc.identifier.doi10.1007/s00246-019-02200-5
dc.identifier.eissn1432-1971
dc.identifier.issn0172-0643
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/34322
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofPediatric Cardiology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectHeart clinicaleng
dc.subjectComplications-heart clinicaleng
dc.subjectPaediatric transplantationeng
dc.subject.otherepstein-barr-viruseng
dc.subject.otherinternational-societyeng
dc.subject.otherlung-transplantationeng
dc.subject.otherregistryeng
dc.subject.otherrituximabeng
dc.subject.otherptldeng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.subject.wosPediatricseng
dc.titleLong-Term Evaluation of Post-transplant Lymphoproliferative Disorders in Paediatric Heart Transplantation in Sao Paulo, Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalARSHAD, Adam:Univ Birmingham, Coll Med & Dent Sci, Birmingham, W Midlands, England; Univ Sao Paulo, Med Sch, Heart Inst InCor, Rua Araripina 95, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcESTELA AZEKA
hcfmusp.contributor.author-fmusphcSAMIA MEDEIROS BARBAR
hcfmusp.contributor.author-fmusphcRAFAEL MARCONDES GONCALVES LEITE
hcfmusp.contributor.author-fmusphcADAILSON WAGNER DA SILVA SIQUEIRA
hcfmusp.contributor.author-fmusphcLUIZ ALBERTO BENVENUTI
hcfmusp.contributor.author-fmusphcNANA MIURA IKARI
hcfmusp.contributor.author-fmusphcMARCELO BISCEGLI JATENE
hcfmusp.contributor.author-fmusphcVICENTE ODONE FILHO
hcfmusp.description.beginpage1655
hcfmusp.description.endpage1662
hcfmusp.description.issue8
hcfmusp.description.volume40
hcfmusp.origemWOS
hcfmusp.origem.pubmed31506731
hcfmusp.origem.scopus2-s2.0-85073973149
hcfmusp.origem.wosWOS:000495776000015
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-06-09
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