Disease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMAIA, Isabel A.
dc.contributor.authorBEZERRA, Frank S.
dc.contributor.authorALBUQUERQUE, Andre Luis Pereira de
dc.contributor.authorANDRADE JR., Heitor F.
dc.contributor.authorNICODEMO, Antonio C.
dc.contributor.authorAMATO, Valdir S.
dc.date.accessioned2017-08-17T19:20:24Z
dc.date.available2017-08-17T19:20:24Z
dc.date.issued2017
dc.description.abstractVisceral leishmaniasis (VL) is associated with interstitial pneumonitis according to histology and radiology reports. However, studies to address the functional impact on respiratory function in patients are lacking. We assessed pulmonary function using noninvasive spirometry in a cross-sectional study of hospitalized adult VL patients from Minas Gerais, Brazil, without unrelated lung conditions or acute infections. Lung conditions were graded as normal, restrictive, obstructive, or mixed patterns, according to Brazilian consensus standards for spirometry. To control for regional patterns of lung function, we compared spirometry of patients with regional paired controls. Spirometry detected abnormal lung function in most VL patients (70%, 14/20), usually showing a restrictive pattern, in contrast to regional controls and the standards for normal tests. Alterations in spirometry measurements correlated with hypoalbuminemia, the only laboratory value indicative of severity of parasitic disease. Abnormalities did not correlate with unrelated factors such as smoking or occupation. Clinical data including pulmonary symptoms and duration of therapy were also unrelated to abnormal spirometry findings. We conclude that the severity of VL is correlated with a restrictive pattern of lung function according to spirometry, suggesting that there may be interstitial lung involvement in VL. Further studies should address whether spirometry could serve as an index of disease severity in the management of VL.
dc.description.indexMEDLINE
dc.description.sponsorshipLIMHCFMUSP
dc.identifier.citationAMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.96, n.2, p.280-284, 2017
dc.identifier.doi10.4269/ajtmh.16-0275
dc.identifier.eissn1476-1645
dc.identifier.issn0002-9637
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21424
dc.language.isoeng
dc.publisherAMER SOC TROP MED & HYGIENE
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER SOC TROP MED & HYGIENE
dc.subject.otherinterstitial pneumonitis
dc.subject.wosPublic, Environmental & Occupational Health
dc.subject.wosTropical Medicine
dc.titleDisease Severity Prediction by Spirometry in Adults with Visceral Leishmaniasis from Minas Gerais, Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBEZERRA, Frank S.:Univ Fed Ouro Preto, Lab Expt Pathophysiol LAFEx, Dept Biol Sci DECBI, Ctr Res Biol Sci NUPEB, Ouro Preto, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcISABEL ARAGAO MAIA
hcfmusp.contributor.author-fmusphcANDRE LUIZ PEREIRA DE ALBUQUERQUE
hcfmusp.contributor.author-fmusphcHEITOR FRANCO DE ANDRADE JUNIOR
hcfmusp.contributor.author-fmusphcANTONIO CARLOS NICODEMO
hcfmusp.contributor.author-fmusphcVALDIR SABBAGA AMATO
hcfmusp.description.beginpage280
hcfmusp.description.endpage284
hcfmusp.description.issue2
hcfmusp.description.volume96
hcfmusp.origemWOS
hcfmusp.origem.pubmed27895274
hcfmusp.origem.scopus2-s2.0-85014521355
hcfmusp.origem.wosWOS:000401767400006
hcfmusp.publisher.cityMCLEAN
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-06-14
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