Perspectives of bilateral thoracic sympathectomy for treatment of heart failure

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art_SILVA_Perspectives_of_bilateral_thoracic_sympathectomy_for_treatment_of_2021.PDF (299.67 KB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2021
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
SIMAS, Rafael
Citação
CLINICS, v.76, article ID e3248, 6p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Surgical neuromodulation therapies are still considered a last resort when standard therapies have failed for patients with progressive heart failure (HF). Although a number of experimental studies have provided robust evidence of its effectiveness, the lack of strong clinical evidence discourages practitioners. Thoracic unilateral sympathectomy has been extensively studied and has failed to show significant clinical improvement in HF patients. Most recently, bilateral sympathectomy effect was associated with a high degree of success in HF models, opening the perspective to be investigated in randomized controlled clinical trials. In addition, a series of clinical trials showed that bilateral sympathectomy was associated with a decreased risk of sudden death, which is an important outcome in patients with HF. These aspects indicates that bilateral sympathectomy could be an important alternative in the treatment of HF wherein pharmacological treatment barely reaches the target dose.
Palavras-chave
Heart Failure, Sympathectomy, Myocardial Infarction, Dilated Cardiomyopathy, Pulmonary Hypertension
URI
https://observatorio.fm.usp.br/handle/OPI/42146
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - ODS/03