Depression and excess mortality in the elderly living in low- and middle-income countries: Systematic review and meta-analysis

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art_BRANDAO_Depression_and_excess_mortality_in_the_elderly_living_2019.PDF (530.88 KB)
Citações na Scopus
37
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
FONTENELLE, Leonardo Ferreira
SILVA, Simone Almeida da
PASTOR-VALERO, Maria
Citação
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v.34, n.1, p.22-30, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective To investigate the association between depression and mortality in the elderly living in low- and middle-income countries. Methods A systematic review and meta-analysis was performed. We searched in five electronic databases for observational studies investigating the association between mortality and depression. Two reviewers worked independently to select articles, extract data, and assess study quality. Results A total of 10 studies including 13 828 participants (2402 depressed and 11 426 nondepressed) from six countries (Brazil, four articles; China, two articles; Botswana, India, South Africa, and South Korea, one article) were included. The overall unadjusted relative risk (RR) of mortality in depressed relative to nondepressed participants was 1.62 (95% CI, 1.39-1.88; P < 0.001), with high heterogeneity (I-2 = 66%; 95% CI, 33-83; P < 0.005). After adjustment for publication bias, the overall RR decreased to 1.60 (95% CI, 1.37-1.86; P < 0.001). No significant differences were observed between subgroups except those defined by study quality. The high-quality studies had a pooled RR of 1.48 (95% CI, 1.32-1.67; P < 0.001), while the low-quality studies resulted had a pooled RR of 1.82 (95% CI, 1.25-2.65; P < 0.005). Conclusions Depression is associated with excess mortality in the elderly living in low- and middle-income countries. In addition, this excess mortality does not differ substantially from that found in high-income countries. This suggests environmental factors occurring in low- and middle-income countries might not have a direct association with the excess mortality in the depressed elderly.
Palavras-chave
depression, low- and middle-income countries, mortality
URI
https://observatorio.fm.usp.br/handle/OPI/30029
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/39