PAULO ROSSI MENEZES
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
206 resultados
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- Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations(2013) TAMASHIRO-DURAN, Jaqueline Hatsuko; SQUARZONI, Paula; DURAN, Fabio Luis de Souza; CURIATI, Pedro Kallas; VALLADA, Homero Pinto; BUCHPIGUEL, Carlos Alberto; LOTUFO, Paulo Andrade; WAJNGARTEN, Mauricio; MENEZES, Paulo Rossi; SCAZUFCA, Marcia; ALVES, Tania Correa de Toledo Ferraz; BUSATTO, Geraldo FilhoCardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein epsilon 4 (APOE epsilon 4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date. The present FDG-PET study investigated 59 cognitively preserved elderlies divided into three groups according to their cardiovascular risk based on the Framingham 10-year risk Coronary Heart Disease Risk Profile (low-, medium-, and high-risk) to examine whether different levels of CVRF would be associated with reduced CMRgl, involving the same brain regions affected in early stages of AD. Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon 4 allele as a confounding covariate. Significant cerebral metabolism reductions were detected in the high-risk group when compared to the low-risk group in the left precuneus and posterior cingulate gyrus. This suggests that findings of brain hypometabolism similar to those seen in subjects with AD can be detected in association with the severity of cardiovascular risk in cognitively preserved individuals. Thus, a greater knowledge about how such factors influence brain functioning in healthy subjects over time may provide important insigths for the future development of strategies aimed at delaying or preventing the vascular-related triggering of pathologic brain changes in the AD.
- Complementary religious and spiritual interventions in physical health and quality of life: A systematic review of randomized controlled clinical trials(2017) GONCALVES, Juliane Piasseschi de Bernardin; LUCCHETTI, Giancarlo; MENEZES, Paulo Rossi; VALLADA, HomeroObjective To examine whether religious and spiritual interventions (RSIs) can promote physical health and quality of life in individuals. Methods The following databases were used to conduct a systematic review: PubMed, Scopus, Web of Science, EMBASE, PsycINFO, Cochrane, and Scielo. Randomized controlled trials that evaluated RSIs regarding physical health outcomes and/or quality of life in English, Spanish or Portuguese were included. RSI protocols performed at a distance (i.e. intercessory prayer) or for psychiatric disorders were excluded. This study consisted of two phases: (a) reading titles and abstracts, and (b) assessing the full articles and their methodological quality using the Cochrane Back Review Group scale. Results In total, 7,070 articles were identified in the search, but 6884 were excluded in phase 1 because they were off topic or repeated in databases. Among the 186 articles included in phase 2, 140 were excluded because they did not fit the inclusion criteria and 16 did not have adequate randomization process. Thus, a final selection of 30 articles remained. The participants of the selected studies were classified in three groups: chronic patients (e.g., cancer, obesity, pain), healthy individuals and healthcare professionals. The outcomes assessed included quality of life, physical activity, pain, cardiac outcomes, promotion of health behaviors, clinical practice of healthcare professionals and satisfaction with protocols. The divergence concerning scales and protocols proposed did not allow a meta-analysis. RSIs as a psychotherapy approach were performed in 40% of the studies, and the control group was more likely to use an educational intervention (56.7%). The results revealed small effect sizes favoring RSIs in quality of life and pain outcomes and very small effects sizes in physical activity, promotion of health behaviors and clinical practice of health professionals compared with other complementary strategies. Other outcomes, such as cardiac measures and satisfaction with the protocols, revealed no evidence for RSIs. Regarding the quality of the selected articles according to the Cochrane Back Review Group Scale, the average score was 6.83 (SD = 9.08) on a scale of 11, demonstrating robustness in the studies. Conclusion Clinical trials on RSIs demonstrated that they had small benefits compared with other complementary health therapies by reducing pain and weight, improving quality of life and promoting health behaviors. The lack of clinical trials that included biological outcomes and the diversity of approaches indicate a need for more studies to understand the possible mechanisms of action of RSIs and their roles in health care.
- Social and clinical features associated with duration of untreated psychosis in the Brazilian STREAM study(2021) SHUHAMA, Rosana; ROCHA, Victoria Helena Stelzer; LOUREIRO, Camila Marcelino; CORSI-ZUELLI, Fabiana; SANTOS, Jair Licio Ferreira; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta
- Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study(2021) AJNAKINA, Olesya; RODRIGUEZ, Victoria; QUATTRONE, Diego; FORTI, Marta di; VASSOS, Evangelos; ARANGO, Celso; BERARDI, Domenico; BERNARDO, Miguel; BOBES, Julio; HAAN, Lieuwe de; DEL-BEN, Cristina Marta; GAYER-ANDERSON, Charlotte; JONGSMA, Hannah E.; LASALVIA, Antonio; TOSATO, Sarah; LLORCA, Pierre-Michel; MENEZES, Paulo Rossi; RUTTEN, Bart P.; SANTOS, Jose Luis; SANJUAN, Julio; SELTEN, Jean-Paul; SZOKE, Andrei; TARRICONE, Ilaria; D'ANDREA, Giuseppe; RICHARDS, Alexander; TORTELLI, Andrea; VELTHORST, Eva; JONES, Peter B.; ROMERO, Manuel Arrojo; CASCIA, Caterina La; KIRKBRIDE, James B.; OS, Jim van; O'DONOVAN, Mick; MURRAY, Robin M.Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain insights into the possible biological impact on DUP, we report genetic analyses of a large multi-center phenotypically well-defined sample encompassing individuals with a diagnosis of FEP recruited from 6 countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. Genetic propensity was measured using polygenic scores for schizophrenia (SZ-PGS), bipolar disorder (BD-PGS), major depressive disorder (MDD-PGS), and intelligence (IQ-PGS), which were calculated based on the results from the most recent genome-wide association meta-analyses. Following imputation for missing data and log transformation of DUP to handle skewedness, the association between DUP and polygenic scores (PGS), adjusting for important confounders, was investigated with multivariable linear regression models. The sample comprised 619 individuals with a diagnosis of FEP disorders with a median age at first contact of 29.0 years (interquartile range [IQR] = 22.0-38.0). The median length of DUP in the sample was 10.1 weeks (IQR = 3.8-30.8). One SD increases in SZ-PGS, BD-PGS, MDD-PGS or IQ-PGS were not significantly associated with the length of DUP. Our results suggest that genetic variation does not contribute to the DUP in patients with a diagnosis of FEP disorders.
- Religious and spiritual interventions in mental health care: a systematic review and meta-analysis of randomized controlled clinical trials(2015) GONCALVES, J. P. B.; LUCCHETTI, G.; MENEZES, P. R.; VALLADA, H.Background. Despite the extensive literature assessing associations between religiosity/spirituality and health, few studies have investigated the clinical applicability of this evidence. The purpose of this paper was to assess the impact of religious/spiritual interventions (RSI) through randomized clinical trials (RCTs). Method. A systematic review was performed in the following databases: PubMed, Scopus, Web of Science, PsycINFO, Cochrane Collaboration, Embase and SciELO. Through the use of a Boolean expression, articles were included if they: (i) investigated mental health outcomes; (ii) had a design consistent with RCTs. We excluded protocols involving intercessory prayer or distance healing. The study was conducted in two phases by reading: (1) title and abstracts; (2) full papers and assessing their methodological quality. Then, a meta-analysis was carried out. Results. Through this method, 4751 papers were obtained, of which 23 remained included. The meta-analysis showed significant effects of RSI on anxiety general symptoms (p < 0.001) and in subgroups: meditation (p < 0.001); psychotherapy (p = 0.02); 1 month of follow-up (p < 0.001); and comparison groups with interventions (p < 0.001). Two significant differences were found in depressive symptoms: between 1 and 6 months and comparison groups with interventions (p = 0.05). In general, studies have shown that RSI decreased stress, alcoholism and depression. Conclusions. RCTs on RSI showed additional benefits including reduction of clinical symptoms (mainly anxiety). The diversity of protocols and outcomes associated with a lack of standardization of interventions point to the need for further studies evaluating the use of religiosity/spirituality as a complementary treatment in health care.
- Depression and excess mortality in the elderly living in low- and middle-income countries: Systematic review and meta-analysis(2019) BRANDAO, Diego Jose; FONTENELLE, Leonardo Ferreira; SILVA, Simone Almeida da; MENEZES, Paulo Rossi; PASTOR-VALERO, MariaObjective To investigate the association between depression and mortality in the elderly living in low- and middle-income countries. Methods A systematic review and meta-analysis was performed. We searched in five electronic databases for observational studies investigating the association between mortality and depression. Two reviewers worked independently to select articles, extract data, and assess study quality. Results A total of 10 studies including 13 828 participants (2402 depressed and 11 426 nondepressed) from six countries (Brazil, four articles; China, two articles; Botswana, India, South Africa, and South Korea, one article) were included. The overall unadjusted relative risk (RR) of mortality in depressed relative to nondepressed participants was 1.62 (95% CI, 1.39-1.88; P < 0.001), with high heterogeneity (I-2 = 66%; 95% CI, 33-83; P < 0.005). After adjustment for publication bias, the overall RR decreased to 1.60 (95% CI, 1.37-1.86; P < 0.001). No significant differences were observed between subgroups except those defined by study quality. The high-quality studies had a pooled RR of 1.48 (95% CI, 1.32-1.67; P < 0.001), while the low-quality studies resulted had a pooled RR of 1.82 (95% CI, 1.25-2.65; P < 0.005). Conclusions Depression is associated with excess mortality in the elderly living in low- and middle-income countries. In addition, this excess mortality does not differ substantially from that found in high-income countries. This suggests environmental factors occurring in low- and middle-income countries might not have a direct association with the excess mortality in the depressed elderly.
- Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study(2023) ALAMEDA, Luis; LIU, Zhonghua; SHAM, Pak C.; AAS, Monica; TROTTA, Giulia; RODRIGUEZ, Victoria; FORTI, Marta Di; STILO, Simona A.; KANDASWAMY, Radhika; ARANGO, Celso; ARROJO, Manuel; BERNARDO, Miguel; BOBES, Julio; HAAN, Lieuwe de; DEL-BEN, Cristina Marta; GAYER-ANDERSON, Charlotte; SIDELI, Lucia; JONES, Peter B.; JONGSMA, Hannah E.; KIRKBRIDE, James B.; CASCIA, Caterina La; LASALVIA, Antonio; TOSATO, Sarah; LLORCA, Pierre-Michel; MENEZES, Paulo Rossi; OS, Jim van; QUATTRONE, Diego; RUTTEN, Bart P.; SANTOS, Jose Luis; SANJUAN, Julio; SELTEN, Jean-Paul; SZOKE, Andrei; TARRICONE, Ilaria; TORTELLI, Andrea; VELTHORST, Eva; MORGAN, Craig; DEMPSTER, Emma; HANNON, Eilis; BURRAGE, Joe; DWIR, Daniella; ARUMUHAM, Atheeshaan; MILL, Jonathan; MURRAY, Robin M.; WONG, Chloe C. Y.AbtractStudies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed. Adversity scores were created for abuse, neglect and composite adversity with the Childhood Trauma Questionnaire (CTQ). Regressions examining (I) CTQ scores with psychosis; (II) with DNAm EWAS level and (III) between DNAm and caseness, adjusted for a variety of confounders were conducted. Divide-Aggregate Composite-null Test for the composite null-hypothesis of no mediation effect was conducted. Enrichment analyses were conducted with missMethyl package and the KEGG database. Our results show that CA was associated with psychosis (Composite: OR = 1.68; p = p < 0.001; neglect: OR = 2.27; p = <0.001). None of the CpG sites significantly mediated the adversity-psychosis association after Bonferroni correction (p < 8.1 x 10(-8)). However, 28, 34 and 29 differentially methylated probes associated with 21, 27, 20 genes passed a less stringent discovery threshold (p < 5 x 10(-5)) for composite, abuse and neglect respectively, with a lack of overlap between abuse and neglect. These included genes previously associated to psychosis in EWAS studies, such as PANK1, SPEG TBKBP1, TSNARE1 or H2R. Downstream gene ontology analyses did not reveal any biological pathways that survived false discovery rate correction. Although at a non-significant level, DNAm changes in genes previously associated with schizophrenia in EWAS studies may mediate the CA-psychosis association. These results and associated involved processes such as mitochondrial or histaminergic disfunction, immunity or neural signalling requires replication in well powered samples. The lack of overlap between mediating genes associated with abuse and neglect suggests differential biological trajectories linking CA subtypes and psychosis.
- Age-related gray matter volume changes in the brain during non-elderly adulthood(2011) TERRIBILLI, Debora; SCHAUFELBERGER, Maristela S.; DURAN, Fabio L. S.; ZANETTI, Marcus V.; CURIATI, Pedro K.; MENEZES, Paulo R.; SCAZUFCA, Marcia; AMARO JR., Edson; LEITE, Claudia C.; BUSATTO, Geraldo F.Previous magnetic resonance imaging (MRI) studies described consistent age-related gray matter (GM) reductions in the fronto-parietal neocortex, insula and cerebellum in elderly subjects, but not as frequently in limbic/paralimbic structures. However, it is unclear whether such features are already present during earlier stages of adulthood, and if age-related GM changes may follow non-linear patterns at such age range. This voxel-based morphometry study investigated the relationship between GM volumes and age specifically during non-elderly life (18-50 years) in 89 healthy individuals (48 males and 41 females). Voxelwise analyses showed significant (p < 0.05, corrected) negative correlations in the right prefrontal cortex and left cerebellum, and positive correlations (indicating lack of GM loss) in the medial temporal region, cingulate gyrus, insula and temporal neocortex. Analyses using ROI masks showed that age-related dorsolateral prefrontal volume decrements followed non-linear patterns, and were less prominent in females compared to males at this age range. These findings further support for the notion of a heterogeneous and asynchronous pattern of age-related brain morphometric changes, with region-specific non-linear features.
- Pre-training inter-rater reliability of clinical instruments in an international psychosis research project(2021) BERENDSEN, Steven; KAPITEIN, Pim; SCHIRMBECK, Frederike; TRICHT, Mirjam J. van; MCGUIRE, Philip; MORGAN, Craig; GAYER-ANDERSON, Charlotte; KEMPTON, Matthew J.; VALMAGGIA, Lucia; QUATTRONE, Diego; FORTI, Marta di; GAAG, Mark van der; KIRKBRIDE, James B.; JONGSMA, Hannah E.; JONES, Peter B.; PARELLADA, Maria; ARANGO, Celso; ARROJO, Manuel; BERNARDO, Miguel; SANJUAN, Julio; SANTOS, Jose Luis; SZOKE, Andrei; TORTELLI, Andrea; LLORCA, Pierre-Michel; TARRICONE, Ilaria; TRIPOLI, Giada; FERRARO, Laura; CASCIA, Caterina La; LASALVIA, Antonio; TOSATO, Sarah; MENEZES, Paulo Rossi; DEL-BEN, Cristina Marta; NELSON, Barnaby; RIECHER-ROSSLER, Anita; BRESSAN, Rodrigo; BARRANTES-VIDAL, Neus; KREBS, Marie-Odile; NORDENTOFT, Merete; RUHRMANN, Stephan; SACHS, Gabriele; RUTTEN, Bart P. F.; OS, Jim van; VELTHORST, Eva; HAAN, Lieuwe de
- Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon(2012) BRAGA, Wornei Silva Miranda; CASTILHO, Marcia da Costa; BORGES, Fabiane Giovanella; MARTINHO, Ana Cristina de Souza; RODRIGUES, Ivo Seixas; AZEVEDO, Eliete Pereira de; SCAZUFCA, Marcia; MENEZES, Paulo RossiIntroduction: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. Methods: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Labrea following nineteen years of HBV vaccination. Results: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003. Conclusions: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups.