Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCAPPI, Carolina
dc.contributor.authorMUNIZ, Renan Kawano
dc.contributor.authorSAMPAIO, Aline Santos
dc.contributor.authorCORDEIRO, Quirino
dc.contributor.authorBRENTANI, Helena
dc.contributor.authorPALACIOS, Selma A.
dc.contributor.authorMARQUES, Andrea H.
dc.contributor.authorVALLADA, Homero
dc.contributor.authorMIGUEL, Euripedes Constantino
dc.contributor.authorGUILHERME, Luiza
dc.contributor.authorHOUNIE, Ana Gabriela
dc.date.accessioned2013-07-30T15:18:57Z
dc.date.available2013-07-30T15:18:57Z
dc.date.issued2012
dc.description.abstractObsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK (R) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic x association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the rote of the immune system in its pathogenesis.
dc.description.abstractO transtorno obsessivo-compulsivo (TOC) é um quadro psiquiátrico de prevalência considerável na população e de etiologia desconhecida. No entanto, há evidências de que o sistema imunológico pode desempenhar um papel importante em sua patogênese. No presente estudo, dois polimorfismos (rs1800795 e rs361525), localizados na região promotora do gene que codifica a citocina conhecida como fator de necrose tumoral alfa (TNFA), foram genotipados em 183 pacientes com TOC e 249 controles saudáveis. Os testes estatísticos foram realizados utilizando-se o software PLINK®. Assim, evidenciou-se que o alelo A do polimorfismo rs361525 apresentava associação estatisticamente significante com o TOC (p=0,007). A presença de marcadores genéticos, tais como genes que codificam citocinas inflamatórias, associados com TOC, confere suporte adicional ao papel do sistema imunológico na patogênese desse transtorno.
dc.description.indexMEDLINE
dc.description.sponsorshipCAPES/PRODOC
dc.description.sponsorshipFAPESP [98/15-013-9, 2005/55628-8]
dc.description.sponsorshipCNPq
dc.identifier.citationARQUIVOS DE NEURO-PSIQUIATRIA, v.70, n.2, p.87-90, 2012
dc.identifier.doi10.1590/S0004-282X2012000200003
dc.identifier.issn0004-282X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1092
dc.language.isoeng
dc.publisherASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsopenAccess
dc.rights.holderCopyright ASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.subjectcytokines
dc.subjectgenetic markers
dc.subjectmental disorder
dc.subjectpolymorphism
dc.subjectcitocinas
dc.subjectmarcadores genéticos
dc.subjecttranstorno mental
dc.subjectpolimorfismo
dc.subject.othernecrosis-factor-alpha
dc.subject.otherpromoter polymorphism
dc.subject.otherdepressive symptoms
dc.subject.otherrheumatic-fever
dc.subject.otherstress
dc.subject.otherbrain
dc.subject.otheridentification
dc.subject.otherepidemiology
dc.subject.otherpopulation
dc.subject.othermechanisms
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleAssociation study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
dc.title.alternativeEstudo de associação entre polimorfismos funcionais do gene do TNF-alfa e transtorno obsessivo-compulsivo
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCORDEIRO, Quirino:Santa Casa Med Sch, Dept Psychiat & Psychol Med, Sao Paulo, Brazil
hcfmusp.citation.scopus24
hcfmusp.contributor.author-fmusphcCAROLINA CAPPI
hcfmusp.contributor.author-fmusphcRENAN KAWANO MUNIZ
hcfmusp.contributor.author-fmusphcALINE SANTOS SAMPAIO
hcfmusp.contributor.author-fmusphcHELENA PAULA BRENTANI
hcfmusp.contributor.author-fmusphcSELMA ALIOTTI PALACIOS
hcfmusp.contributor.author-fmusphcANDREA DE FATIMA HORVATH MARQUES
hcfmusp.contributor.author-fmusphcHOMERO PINTO VALLADA FILHO
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.contributor.author-fmusphcLUIZA GUILHERME GUGLIELMI
hcfmusp.contributor.author-fmusphcANA GABRIELA HOUNIE
hcfmusp.description.beginpage87
hcfmusp.description.endpage90
hcfmusp.description.issue2
hcfmusp.description.volume70
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22311210
hcfmusp.origem.scieloSCIELO:S0004-282X2012000200003
hcfmusp.origem.scopus2-s2.0-84857136589
hcfmusp.origem.wosWOS:000300650300003
hcfmusp.publisher.citySAO PAULO SP
hcfmusp.publisher.countryBRAZIL
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hcfmusp.remissive.sponsorshipCAPES
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