First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKOSTIC, Dusan
dc.contributor.authorBEOZZO, Glenda Priscila Neves dos Santos
dc.contributor.authorCOUTO, Saulo Brasil do
dc.contributor.authorKATO, Andre Henrique Teruaki
dc.contributor.authorLIMA, Laila
dc.contributor.authorPALMEIRA, Patricia
dc.contributor.authorKREBS, Vera Lucia Jornada
dc.contributor.authorBUNDUKI, Victor
dc.contributor.authorFRANCISCO, Rossana Pulcineli Vieira
dc.contributor.authorZUGAIB, Marcelo
dc.contributor.authorCARVALHO, Werther Brunow de
dc.contributor.authorKOCH, Vera Hermina Kalika
dc.date.accessioned2019-06-26T17:30:48Z
dc.date.available2019-06-26T17:30:48Z
dc.date.issued2019
dc.description.abstractBackground Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage. Methods This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-beta 1), retinol-binding protein (RBP), cystatin C (mu CyC), and microalbuminuria (ALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Results All urine biomarkers showed significantly higher values at the first month of life (p <= 0.009), while NGAL (p = 0.005), TGF-beta 1 (p<0.001), and mu ALB (p<0.001) were high since birth compared to controls. Best single biomarker performances were RBP in bilateral hydronephrosis and LUTO subgroups and KIM-1 in unilateral hydronephrosis subgroup. Best biomarker combination results for all subgroups were obtained by matching RBP with TGF-beta 1 or KIM-1 and NGAL with CyC ([AUC] <= 0.934; sensitivity <= 92.4%; specificity <= 92.8%). Conclusions RBP, NGAL, KIM-1, TGF-beta 1, and CyC, alone and especially in combination, are relatively efficient in identifying surgically amenable congenital UTO and could be of practical use in indicating on-time surgery.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipSao Paulo Research Foundation-FAPESP Grant [2012/50337-9]
dc.identifier.citationPEDIATRIC NEPHROLOGY, v.34, n.6, p.1117-1128, 2019
dc.identifier.doi10.1007/s00467-019-4195-4
dc.identifier.eissn1432-198X
dc.identifier.issn0931-041X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32493
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofPediatric Nephrology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectCongenital urinary tract obstructioneng
dc.subjectHydronephrosiseng
dc.subjectRenal biomarkerseng
dc.subjectInfantseng
dc.subject.otherureteropelvic junction obstructioneng
dc.subject.othercystatin-ceng
dc.subject.otherchildreneng
dc.subject.othernewborneng
dc.subject.otherkidneyeng
dc.subject.otherhydronephrosiseng
dc.subject.otherclassificationeng
dc.subject.otherdilatationeng
dc.subject.othercreatinineeng
dc.subject.othermanagementeng
dc.subject.wosPediatricseng
dc.subject.wosUrology & Nephrologyeng
dc.titleFirst-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstructioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcDUSAN KOSTIC
hcfmusp.contributor.author-fmusphcGLENDA PRISCILA NEVES DOS SANTOS BEOZZO
hcfmusp.contributor.author-fmusphcSAULO BRASIL DO COUTO
hcfmusp.contributor.author-fmusphcANDRE HENRIQUE TERUAKI KATO
hcfmusp.contributor.author-fmusphcLAILA LIMA
hcfmusp.contributor.author-fmusphcPATRICIA PALMEIRA DAENEKAS JORGE
hcfmusp.contributor.author-fmusphcVERA LUCIA JORNADA KREBS
hcfmusp.contributor.author-fmusphcVICTOR BUNDUKI
hcfmusp.contributor.author-fmusphcROSSANA PULCINELI VIEIRA FRANCISCO
hcfmusp.contributor.author-fmusphcMARCELO ZUGAIB
hcfmusp.contributor.author-fmusphcWERTHER BRUNOW DE CARVALHO
hcfmusp.contributor.author-fmusphcVERA HERMINA KALIKA KOCH
hcfmusp.description.beginpage1117
hcfmusp.description.endpage1128
hcfmusp.description.issue6
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.pubmed30694385
hcfmusp.origem.scopus2-s2.0-85061047209
hcfmusp.origem.wosWOS:000468519900017
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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