Placental pathological findings in coronavirus disease 2019: Perinatal outcomes
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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
W B SAUNDERS CO LTD
Citação
PLACENTA, v.128, p.23-28, 2022
Resumo
Introduction: Placental alterations caused by severe acute respiratory coronavirus-2 (SARS-CoV-2) infection have already been described, but most studies used small sample groups and the difference according to the severity of the disease has not been verified. Our objective was to describe placental alterations in patients with coronavirus disease 2019 (COVID-19) and analyze the association of pathological placental findings with the clinical pa-rameters of COVID-19 and perinatal results.Methods: This was a nested study within a prospective cohort study involving 109 symptomatic pregnant women with COVID-19. The prevalence of observed placental alterations was described, and the associations of path-ological findings with the clinical parameters of COVID-19 severity and with perinatal outcomes were assessed.Results: The frequency of types of placental features was poor maternal vascular perfusion in 45% of cases, poor fetal vascular perfusion in 33.9%, hematogenous origin infection in 32.1%, and morphological changes corre-sponding to ascending infection in 21.1%. Hematogenous infection differed significantly according to COVID-19 severity (p = 0.008), with a prevalence ratio (PR) of 1.74 (95% confidence interval, 1.02-2.98) in the moderate COVID-19 group compared to the mild COVID-19 group. Among the perinatal outcomes, there was an unex-pected inverse association between prematurity and placental infection of hematogenous origin, with lower rates of prematurity among cases with inflammation of hematogenous origin (p = 0.029).Discussion: Moderate SARS-Cov-2 infection presented a higher prevalence of placental pathological findings. There was no association of placental findings with adverse perinatal outcomes.
Palavras-chave
Placenta, COVID-19, Perinatal mortality, Infectious pregnancy complications
Referências
- ALTSHULER G, 1984, ARCH PATHOL LAB MED, V108, P71
- Baergen RN, 2020, PEDIATR DEVEL PATHOL, V23, P177, DOI 10.1177/1093526620925569
- Santana LB, 2021, J OBSTET GYNAECOL RE, V47, P2131, DOI 10.1111/jog.14784
- Brito S.B.P., 2020, J BRAS PATOL MED LAB, V56, P1, DOI [10.5935/1676-2444.20200056, DOI 10.5935/1676-2444.20200056]
- Buckley T, 2021, CUREUS, V13, DOI 10.7759/cureus.12522
- Cribiu FM, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI145427
- Debelenko L, 2021, HUM PATHOL, V109, P69, DOI 10.1016/j.humpath.2020.12.004
- Di Toro F, 2021, CLIN MICROBIOL INFEC, V27, P36, DOI 10.1016/j.cmi.2020.10.007
- Gomez UT, 2022, CLINICS, V77, DOI 10.1016/j.clinsp.2022.100073
- Grasselli G, 2020, LANCET RESP MED, V8, P1201, DOI 10.1016/S2213-2600(20)30370-2
- Gulersen M, 2020, AM J OBST GYNEC MFM, V2, DOI 10.1016/j.ajogmf.2020.100211
- He M, 2022, FETAL PEDIATR PATHOL, V41, P403, DOI 10.1080/15513815.2020.1828517
- Hecht JL, 2020, MODERN PATHOL, V33, P2092, DOI 10.1038/s41379-020-0639-4
- Hosier H., 2020, MEDRXIV, DOI [10.1101/2020.04.30.20083907, DOI 10.1101/2020.04.30.20083907]
- Jamieson DJ, 2022, AM J OBSTET GYNECOL, V226, P177, DOI 10.1016/j.ajog.2021.08.054
- Khong TY, 2016, ARCH PATHOL LAB MED, V140, P698, DOI 10.5858/arpa.2015-0225-CC
- Kim CJ, 2015, AM J OBSTET GYNECOL, V213, pS53, DOI 10.1016/j.ajog.2015.08.041
- Kim CJ, 2015, AM J OBSTET GYNECOL, V213, pS29, DOI 10.1016/j.ajog.2015.08.040
- Knight M, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m2107
- Kotlar B, 2021, REPROD HEALTH, V18, DOI 10.1186/s12978-021-01070-6
- Kreis NN, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9081777
- Levitan D, 2021, ARCH PATHOL LAB MED, V145, P648, DOI 10.5858/arpa.2020-0793-SA
- Ministerio da Saude, 2021, MANUAL RECOMENDACOES
- Narang K, 2020, MAYO CLIN PROC, V95, P1750, DOI 10.1016/j.mayocp.2020.05.011
- Ochani RohanKumar, 2021, Infez Med, V29, P20
- Patberg ET, 2021, AM J OBSTET GYNECOL, V224, DOI 10.1016/j.ajog.2020.10.020
- Prabhu M, 2020, BJOG-INT J OBSTET GY, V127, P1548, DOI 10.1111/1471-0528.16403
- Prochaska E, 2020, AM J REPROD IMMUNOL, V84, DOI 10.1111/aji.13306
- Resta L, 2021, VIRUSES-BASEL, V13, DOI 10.3390/v13050723
- Roberts D.J., 2021, ATLAS PLACENT PATHOL, Vfirst, P528
- Shanes ED, 2020, AM J CLIN PATHOL, V154, P23, DOI 10.1093/ajcp/aqaa089
- Smithgall MC, 2020, HISTOPATHOLOGY, V77, P994, DOI 10.1111/his.14215
- Taglauer E, 2020, PLACENTA, V100, P69, DOI 10.1016/j.placenta.2020.08.015
- Tasca C, 2021, PLACENTA, V110, P9, DOI 10.1016/j.placenta.2021.04.002
- Wastnedge EAN, 2021, PHYSIOL REV, V101, P303, DOI 10.1152/physrev.00024.2020
- Wong YP, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11010094
- Zhang PL, 2020, AM J OBST GYNEC MFM, V2, DOI 10.1016/j.ajogmf.2020.100197
Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/36
Carregar mais Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/36