Effects of local and remote ischemic postconditioning methods on ischemia-reperfusion injury in a young animal model of acute mesenteric ischemia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorABREU, Mateus Souza
dc.contributor.authorTANNURI, Ana Cristina Aoun
dc.contributor.authorRODRIGUES, Rafael Felipe Goncalves
dc.contributor.authorSILVA, Rafael Jose da
dc.contributor.authorGONCALVES, Josiane de Oliveira
dc.contributor.authorSERAFINI, Suellen
dc.contributor.authorTANNURI, Uenis
dc.date.accessioned2023-08-16T18:01:52Z
dc.date.available2023-08-16T18:01:52Z
dc.date.issued2023
dc.description.abstractPurpose: Acute mesenteric ischemia (AMI) is a condition in pediatric surgery that ranges from intestine necrosis to death. Ischemic postconditioning (IPoC) methods were developed to reduce the damage caused by revascularization. This study aimed to evaluate the efficacy of these methods in an experimental weaning rat model. Methods: Thirty-two 21-day-old Wistar rats were allocated into four groups according to the surgical procedure performed: control, ischemia-reperfusion injury (IRI), local (LIPoC) and remote IPoC (RIPoC). At euthanasia, fragments of the intestine, liver, lungs, and kidneys were submitted to histological, histomorphometric, and molecular analyses. Results: In the duodenum, intestines, and kidneys histological alterations promoted by IRI were reversed by remote postconditioning method. In the distal ileum, the histomorphometric alterations could be reversed by the postconditioning methods with more evident effects promoted by the remote method. The molecular analysis found that the levels of expression of Bax (proapoptotic) and Bcl-XL (antiapoptotic) genes in the intestine were increased by IRI. These alterations were equally reversed by the postconditioning methods, with more evident effects of the remote method. Conclusion: IPoC methods positively reduced the damage caused by IRI in weaning rats.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.indexScielo
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2019/12465-4]
dc.identifier.citationACTA CIRURGICA BRASILEIRA, v.38, article ID e381323, 10p, 2023
dc.identifier.doi10.1590/acb381323
dc.identifier.eissn1678-2674
dc.identifier.issn0102-8650
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54752
dc.language.isoeng
dc.publisherACTA CIRURGICA BRASILEIRAeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsopenAccesseng
dc.rights.holderCopyright ACTA CIRURGICA BRASILEIRAeng
dc.subjectIschemiaeng
dc.subjectReperfusion Injuryeng
dc.subjectIschemic Postconditioningeng
dc.subjectAntioxidantseng
dc.subjectRatseng
dc.subject.othermucosal lesioneng
dc.subject.othersizeeng
dc.subject.wosSurgeryeng
dc.titleEffects of local and remote ischemic postconditioning methods on ischemia-reperfusion injury in a young animal model of acute mesenteric ischemiaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcMATEUS SOUZA ABREU
hcfmusp.contributor.author-fmusphcANA CRISTINA AOUN TANNURI
hcfmusp.contributor.author-fmusphcRAFAEL FELIPE GONCALVES RODRIGUES
hcfmusp.contributor.author-fmusphcRAFAEL JOSE DA SILVA
hcfmusp.contributor.author-fmusphcJOSIANE DE OLIVEIRA GONCALVES
hcfmusp.contributor.author-fmusphcSUELLEN SERAFINI
hcfmusp.contributor.author-fmusphcUENIS TANNURI
hcfmusp.description.articlenumbere381323
hcfmusp.description.volume38
hcfmusp.origemWOS
hcfmusp.origem.pubmed37283357
hcfmusp.origem.scieloSCIELO:S0102-86502023000100216
hcfmusp.origem.scopus2-s2.0-85161227547
hcfmusp.origem.wosWOS:001007237700001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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