Physical capacity increase in patients with heart failure is associated with improvement in muscle sympathetic nerve activity

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOES-SANTOS, Beatriz R.
dc.contributor.authorRONDON, Eduardo
dc.contributor.authorFONSECA, Guilherme W. P.
dc.contributor.authorSALES, Allan R. K.
dc.contributor.authorSANTOS, Marcelo R.
dc.contributor.authorANTUNES-CORREA, Ligia M.
dc.contributor.authorUENO-PARDI, Linda M.
dc.contributor.authorOLIVEIRA, Patricia
dc.contributor.authorTREVIZAN, Patricia F.
dc.contributor.authorFRANCO, Fabio G. Mello
dc.contributor.authorFRAGA, Raffael
dc.contributor.authorALVES, Maria Janieire N. N.
dc.contributor.authorRONDON, Maria Urbana P. B.
dc.contributor.authorHAJJAR, Ludhmila A.
dc.contributor.authorKALIL FILHO, Roberto
dc.contributor.authorNEGRAO, Carlos E.
dc.date.accessioned2023-06-21T14:06:51Z
dc.date.available2023-06-21T14:06:51Z
dc.date.issued2023
dc.description.abstractBackground: Exercise training improves physical capacity in patients with heart failure with reduced ejection fraction (HFrEF), but the mechanisms involved in this response is not fully understood. The aim of this study was to determine if physical capacity increase in patients HFrEF is associated with muscle sympathetic nerve activity (MSNA) reduction and muscle blood flow (MBF) increase. Methods: The study included 124 patients from a 17-year database, divided according to exercise training status: 1) exercise-trained (ET, n = 83) and 2) untrained (UNT, n = 41). MSNA and MBF were obtained using microneurography and venous occlusion plethysmography, respectively. Physical capacity was evaluated by cardiopulmonary exercise test. Moderate aerobic exercise was performed 3 times/wk. for 4 months. Results: Exercise training increased peak oxygen consumption (VO2, 16.1 +/- 0.4 vs 18.9 +/- 0.5 mL.kg(-1).min(-1), P < 0.001), LVEF (28 +/- 1 vs 30 +/- 1%, P = 0.027), MBF (1.57 +/- 0.06 vs 2.05 +/- 0.09 mL.min(-1).100 ml(-1), P < 0.001) and muscle vascular conductance (MVC, 1.82 +/- 0.07 vs 2.45 +/- 0.11 units, P < 0.001). Exercise training significantly decreased MSNA (45 +/- 1 vs 32 +/- 1 bursts/min, P < 0.001). The logistic regression analyses showed that MSNA [(OR) 0.921, 95% CI 0.883-0.962, P < 0.001] was independently associated with peak VO2. Conclusions: The increase in physical capacity provoked by aerobic exercise in patients with HFrEF is associated with the improvement in MSNA.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipResearch, Innovation and Dissemina- tion Center-Obesity and Comorbidities Research Center of the Sao Paulo Research Foundation (FAPESP) [2013/07607-8]
dc.description.sponsorshipConselho Nacional de Desenvolvimento
dc.identifier.citationINTERNATIONAL JOURNAL OF CARDIOLOGY, v.378, p.48-54, 2023
dc.identifier.doi10.1016/j.ijcard.2023.02.018
dc.identifier.eissn1874-1754
dc.identifier.issn0167-5273
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53846
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTDeng
dc.relation.ispartofInternational Journal of Cardiology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.subjectHeart failureeng
dc.subjectExercise trainingeng
dc.subjectPeak oxygen consumptioneng
dc.subjectMuscle sympathetic nerve activityeng
dc.subject.otherexercise training preventseng
dc.subject.otherquality-of-lifeeng
dc.subject.otherneurovascular controleng
dc.subject.otherskeletal-muscleeng
dc.subject.otherblood-floweng
dc.subject.otherfunctional-capacityeng
dc.subject.otherimpacteng
dc.subject.otherrehabilitationeng
dc.subject.othermetaboreflexeng
dc.subject.otherbenefitseng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titlePhysical capacity increase in patients with heart failure is associated with improvement in muscle sympathetic nerve activityeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSALES, Allan R. K.:D Or Inst Res & Educ IDOR, Sao Paulo, Brazil
hcfmusp.author.externalANTUNES-CORREA, Ligia M.:Univ Campinas UNICAMP, Sch Phys Educ, Campinas, SP, Brazil
hcfmusp.author.externalUENO-PARDI, Linda M.:Univ Sao Paulo, Escola Artes Ciencias & Human, Sao Paulo, SP, Brazil
hcfmusp.author.externalTREVIZAN, Patricia F.:Univ Fed Minas Gerais UFMG, Dept Phys Therapy, Belo Horizonte, MG, Brazil
hcfmusp.author.externalFRANCO, Fabio G. Mello:Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
hcfmusp.author.externalFRAGA, Raffael:Alta Diagnost DASA, Sao Paulo, SP, Brazil
hcfmusp.author.externalRONDON, Maria Urbana P. B.:Univ Sao Paulo, Escola Educ Fis & Esporte, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcBEATRIZ RAFAELLE GOES DOS SANTOS
hcfmusp.contributor.author-fmusphcEDUARDO RONDON
hcfmusp.contributor.author-fmusphcGILTON MARQUES FONSECA
hcfmusp.contributor.author-fmusphcMARCELO RODRIGUES DOS SANTOS
hcfmusp.contributor.author-fmusphcPATRICIA ALVES DE OLIVEIRA
hcfmusp.contributor.author-fmusphcMARIA JANIEIRE DE NAZARE NUNES ALVES
hcfmusp.contributor.author-fmusphcLUDHMILA ABRAHAO HAJJAR
hcfmusp.contributor.author-fmusphcROBERTO KALIL FILHO
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO NEGRAO
hcfmusp.description.beginpage48
hcfmusp.description.endpage54
hcfmusp.description.volume378
hcfmusp.origemWOS
hcfmusp.origem.pubmed36791967
hcfmusp.origem.scopus2-s2.0-85148879472
hcfmusp.origem.wosWOS:000956150200001
hcfmusp.publisher.cityCLAREeng
hcfmusp.publisher.countryIRELANDeng
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