Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOEIRO, Alexandre de Matos
dc.contributor.authorSOEIRO, Maria Carolina Feres de Almeida
dc.contributor.authorOLIVEIRA JR., Mucio Tavares de
dc.contributor.authorSERRANO JR., Carlos Viente
dc.date.accessioned2015-04-22T22:07:49Z
dc.date.available2015-04-22T22:07:49Z
dc.date.issued2014
dc.description.abstractObjective: Due to the chronic inflammation associated with systemic lupus erythematosus (SLE), patients develop premature atherosclerosis and the disease is a risk factor for acute myocardial infarction. The best interventional treatment for acute coronary syndrome (ACS) in these patients is unclear. The objective of this study is to describe the baseline characteristics, clinical manifestations, treatment and in-hospital outcome of patients with SLE and ACS. Methods: Eleven SLE patients with ACS were analyzed retrospectively between 2004 and 2011. The following data were obtained: age, gender, clinical and electrocardiographic characteristics, Killip class, risk factors for ACS, myocardial necrosis markers (CK-MB and troponin), creatinine clearance, left ventricular ejection fraction, inflammatory markers (C-reactive protein and erythrocyte sedimentation rate), drugs used during hospital stay, treatment (medical, percutaneous or surgical) and in-hospital outcome. The statistical analysis is presented in percentages and absolute values. Results: Ten of the patients (91%) were women. The median age was 47 years. Typical precordial pain was present in 91%. Around 73% had positive erythrocyte sedimentation rate. The vessel most often affected was the anterior descending artery, in 73%. One patient underwent coronary artery bypass grafting, seven underwent percutaneous coronary intervention with bare-metal stents and three were treated medically. In-hospital mortality was 18%. Conclusions: Despite the small number of patients, our findings were similar to those in the literature, showing coronary artery disease in young people with SLE due to premature atherosclerosis and a high mortality rate.
dc.description.indexMEDLINE
dc.identifier.citationREVISTA PORTUGUESA DE CARDIOLOGIA, v.33, n.11, p.685-690, 2014
dc.identifier.doi10.1016/j.repc.2014.01.007
dc.identifier.eissn0304-4750
dc.identifier.issn0870-2551
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8929
dc.language.isopor
dc.publisherELSEVIER DOYMA SL
dc.relation.ispartofRevista Portuguesa de Cardiologia
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER DOYMA SL
dc.subjectSystemic lupus erythematosus
dc.subjectAcute coronary syndromes
dc.subjectInflammation
dc.subject.otherrisk-factors
dc.subject.otherheart-disease
dc.subject.otherantiphospholipid syndrome
dc.subject.othercardiovascular-disease
dc.subject.otherinsulin-resistance
dc.subject.otherartery-disease
dc.subject.otheratherosclerosis
dc.subject.otherinflammation
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleClinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcALEXANDRE DE MATOS SOEIRO
hcfmusp.contributor.author-fmusphcMARIA CAROLINA FERES DE ALMEIDA SOEIRO
hcfmusp.contributor.author-fmusphcMUCIO TAVARES DE OLIVEIRA JUNIOR
hcfmusp.contributor.author-fmusphcCARLOS VICENTE SERRANO JUNIOR
hcfmusp.description.beginpage685
hcfmusp.description.endpage690
hcfmusp.description.issue11
hcfmusp.description.volume33
hcfmusp.origemWOS
hcfmusp.origem.pubmed25443337
hcfmusp.origem.scopus2-s2.0-84918815471
hcfmusp.origem.wosWOS:000345814000003
hcfmusp.publisher.cityBARCELONA
hcfmusp.publisher.countrySPAIN
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hcfmusp.scopus.lastupdate2024-05-10
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