Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats

Imagem de Miniatura
Arquivos
art_MOSTARDA_Exercise_training_prevents_diastolic_dysfunction_induced_by_metabolic_2012.PDF (536.33 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2012
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
ANGELIS, Katia De
FARAH, Vera de Moura Azevedo
Citação
CLINICS, v.67, n.7, p.815-820, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05. RESULTS: Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 +/- 0.2 vs. C: 4.5 +/- 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 +/- 3 vs. C: 104 +/- 4 mmHg) and obesity (F: 0.31 +/- 0.001 vs. C: 0.29 +/- 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function. CONCLUSION: The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome.
Palavras-chave
Metabolic Syndrome, Diastolic function, Exercise Training, Cardiac hypertrophy
URI
https://observatorio.fm.usp.br/handle/OPI/1540
Referências
  1. Alves AJ, 2011, MED SCI SPORTS EXERC
  2. Bacchi E, 2012, DIABETES CARE, V35, P676, DOI 10.2337/dc11-1655
  3. Basciano H, 2005, NUTR METAB, V2, P5, DOI 10.1186/1743-7075-2-5
  4. BERNARDI.LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
  5. Bertagnolli M, 2008, AM J HYPERTENS, V21, P1188, DOI 10.1038/ajh.2008.270
  6. Bray GA, 2004, AM J CLIN NUTR, V79, P537
  7. Brito JO, 2008, BRAZ J MED BIOL RES, V41, P804, DOI 10.1590/S0100-879X2008005000030
  8. Carroll S, 2004, SPORTS MED, V34, P371, DOI 10.2165/00007256-200434060-00004
  9. Durstine J L, 1994, Exerc Sport Sci Rev, V22, P477
  10. Elliott SS, 2002, AM J CLIN NUTR, V76, P911
  11. Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
  12. Farah V, 2007, AM J PHYSIOL-HEART C, V293, pH1083, DOI 10.1152/ajpheart.00106.2006
  13. Ferder L, 2010, CURR HYPERTENS REP, V12, P105, DOI 10.1007/s11906-010-0097-3
  14. Girman CJ, 2004, AM J CARDIOL, V93, P136, DOI 10.1016/j.amjcard.2003.09.028
  15. Hagg U, 2004, CLIN SCI, V107, P571
  16. Ignarro LJ, 2007, CARDIOVASC RES, V73, P326, DOI 10.1016/j.cardiores.2006.06.030
  17. Jakicic JM, 2001, MED SCI SPORT EXER, V33, P2145, DOI 10.1097/00005768-200112000-00026
  18. Krieger EM, 2001, ANN NY ACAD SCI, V940, P338
  19. Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
  20. LAROVERE MT, 2002, NY TIMES 1026, V106, P945, DOI 10.1161/01.CIR.00000237565.12764.E1
  21. Laterza MC, 2007, HYPERTENSION, V49, P1298, DOI 10.1161/HYPERTENSIONAHA.106.085548
  22. Legramante JM, 2007, AM J PHYSIOL-HEART C, V292, pH510, DOI 10.1152/ajpheart.00748.2006
  23. Moraes-Silva IC, 2010, CLIN EXP PHARMACOL P, V37, pe114, DOI 10.1111/j.1440-1681.2009.05333.x
  24. Mostarda C, 2009, AUTON NEUROSCI-BASIC, V145, P11, DOI 10.1016/j.autneu.2008.10.010
  25. Mostarda C, 2010, CLIN EXP PHARMACOL P, V37, P447, DOI 10.1111/j.1440-1681.2009.05327.x
  26. REAVEN GM, 1988, HYPERTENSION, V12, P129
  27. Rodrigues B, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-38
  28. Senechal M, 2012, METAB SYNDR RELAT DI
  29. Sliem Hamdy, 2011, J Cardiovasc Dis Res, V2, P23, DOI 10.4103/0975-3583.78583
  30. Wichi R, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-14
  31. Xing SS, 2010, MOL MED, V16, P465, DOI 10.2119/molmed.2010.00028
  32. Zamo FS, 2011, LIFE SCI, V89, P93, DOI 10.1016/j.lfs.2011.05.004
  33. [Anonymous], 2005, 1 BRAZILIAN GUIDELIN

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - LIM/59