Impact of COVID-19 on healthcare-associated infections: Antimicrobial consumption does not follow antimicrobial resistance

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art_FREIRE_Impact_of_COVID19_on_healthcareassociated_infections_Antimicrobial_consumption_2023.PDF (1.11 MB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2023
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER ESPANA
Autores
BRITO, Valquiria O. C.
LAPCHIK, Milton
MADALOSSO, Geraldine
LIMA, Antonio Carlos Pedroso de
Citação
CLINICS, v.78, article ID 100231, 7p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: This study aimed to analyze the Healthcare-Associated Infections (HAI) rates and antimicrobial consumption in Intensive Care Units (ICU) in Sao Paulo city during the COVID-19 pandemic and compare them with the pre-pandemic period. Methods: This cohort included all hospitals that reported HAI rates (Central-Line-Associated Bloodstream Infection CLABSI and Ventilator-Associated Pneumonia - VAP), the proportion of microorganisms that caused CLABSI, the proportion of resistant microorganisms, and antimicrobial consumption from January 2017 - December 2020. Hospitals were stratified by the number of beds, Central Venous Catheter (CVC) utilization rate, Mechanical-Ventilation (MV) utilization rate, and type of funding. Statistical analyses were based on time-series plots and regression models. Results: 220 ICUs were included. The authors observed an abrupt increase in CLABSI rates after the pandemic onset. High CLABSI rates during the pandemic were associated with hospital size, funding (public and non-profit private), and low CVC use (<= 50%). An increase in VAP rates was associated with public hospitals, and high MV use (> 35%). The susceptibility profile of microorganisms did not differ from that of the pre-pandemic period. polymyxin, glycopeptides, and antifungal use increased, especially in COVID-19 ICUs. Conclusions: HAI increased during COVID-19. The microorganisms' susceptibility profile did not change with the pandemic, but the authors observed a disproportionate increase in large-spectrum antimicrobial drug use.
Palavras-chave
Multidrug-resistance, COVID-19, Antimicrobial consumption, Pneumonia, Bloodstream infection
URI
https://observatorio.fm.usp.br/handle/OPI/56108
Referências
  1. Assi MA, 2022, INFECT CONT HOSP EP, V43, P813, DOI 10.1017/ice.2021.92
  2. Assis DB, 2018, J HOSP INFECT, V100, pE163, DOI 10.1016/j.jhin.2018.04.020
  3. Baccolini V, 2021, ANTIMICROB RESIST IN, V10, DOI 10.1186/s13756-021-00959-y
  4. Baker MA, 2022, CLIN INFECT DIS, V74, P1748, DOI 10.1093/cid/ciab688
  5. CDC/NHSN, 2021, CDC NHSN SURVEILLANC
  6. Dias VMDH, 2022, J HOSP INFECT, V120, P43, DOI 10.1016/j.jhin.2021.11.011
  7. Ferrando C, 2020, INTENS CARE MED, V46, P2200, DOI 10.1007/s00134-020-06192-2
  8. Fumagalli J, 2022, CURR OPIN CRIT CARE, V28, P74, DOI 10.1097/MCC.0000000000000908
  9. Garnier M, 2023, ANAESTH CRIT CARE PA, V42, DOI 10.1016/j.accpm.2022.101184
  10. Geffers C, 2022, ANTIMICROB RESIST IN, V11, DOI 10.1186/s13756-022-01108-9
  11. Grasselli G, 2021, CHEST, V160, P454, DOI 10.1016/j.chest.2021.04.002
  12. Instituto Brasileiro de Geografia e Estatistica-IBGE, US
  13. Kariyawasam RM, 2022, ANTIMICROB RESIST IN, V11, DOI 10.1186/s13756-022-01085-z
  14. Langford BJ, 2020, CLIN MICROBIOL INFEC, V26, P1622, DOI 10.1016/j.cmi.2020.07.016
  15. Lobo SM, 2022, CHEST, V161, P1526, DOI 10.1016/j.chest.2022.01.057
  16. Musuuza JS, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0251170
  17. Pandey M, 2022, CRIT CARE, V26, DOI 10.1186/s13054-022-04026-9
  18. Polly M, 2022, AM J INFECT CONTROL, V50, P32, DOI 10.1016/j.ajic.2021.09.018
  19. Puzniak L, 2021, OPEN FORUM INFECT DI, V8, pofab232
  20. Seaton RA, 2020, J INFECTION, V81, P952, DOI 10.1016/j.jinf.2020.09.024
  21. Shukla BS, 2021, EMERG INFECT DIS, V27, P2588, DOI 10.3201/eid2710.210538
  22. Sturm LK, 2022, AM J INFECT CONTROL, V50, P245, DOI 10.1016/j.ajic.2021.12.018
  23. Vaughn VM, 2021, CLIN INFECT DIS, V72, pE533, DOI 10.1093/cid/ciaa1239
  24. Wee LEI, 2021, AM J INFECT CONTROL, V49, P469, DOI 10.1016/j.ajic.2020.10.019
  25. Weiner-Lastinger LM, 2022, INFECT CONT HOSP EP, V43, P12, DOI 10.1017/ice.2021.362

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/47
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