The Supralimus (R) sirolimus-eluting stent

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEMOS, Pedro A.
dc.contributor.authorBIENERT, Igor
dc.date.accessioned2013-09-23T16:53:31Z
dc.date.available2013-09-23T16:53:31Z
dc.date.issued2013
dc.description.abstractThe use of biodegradable polymeric coatings has emerged as a potential bioengineering target to improve the vascular compatibility of coronary drug-eluting stents (DESs). This review summarizes the main features and scientific facts about the Supralimus (R) sirolimus-eluting stent (Sahajanand Medical Technologies Ltd, Surat, India), which is a biodegradable polymer-based, sirolimus-eluting metallic stent that was recently introduced for routine use in Europe. The novel stent is built on a stainless steel platform, coated with a blend of biodegradable polymers (poly-l-lactide, poly-dl-lactide-co-glycolide and polyvinyl pyrrolidone; coating thickness is 4-5 mu m). The active agent is the antiproliferative sirolimus in a dose load of 1.4 mu g/mm(2), which is released within 48 days. The Supralimus stent was initially evaluated in the single-arm SERIES-I study, which showed binary angiographic restenosis rates of 0% (in-stent) and 1.7% (in-segment) and an instent late lumen loss of 0.09 +/- 0.28 mm. The multicenter randomized PAINT trial compared two DESs with identical metallic platforms and biodegradable polymer carriers, but different agents (Infinnium (R) [Sahajanand Medical Technologies Pvt Ltd] paclitaxel-eluting stent or Supralimus sirolimus-eluting stent) against bare stents. After 3 years, the pooled DES population had similar rates of cardiac death or myocardial infarction (9 vs 7.1%; p = 0.6), but a lower risk of repeat interventions (10 vs 29.9%; p < 0.01) than controls with bare stents. The incidence of definite or probable stent thrombosis in the pooled DES group was 2.3% (1st year: 1.8%; 2nd year: 0.4% and 3rd year: 0%). These results demonstrate that the novel Supralimus stents are effective in reducing reintervention, while potentially improving the safety profile by decreasing the risk of late-term thrombosis, even though further studies would be necessary to confirm these findings.
dc.description.indexMEDLINE
dc.identifier.citationEXPERT REVIEW OF MEDICAL DEVICES, v.10, n.3, p.295-300, 2013
dc.identifier.doi10.1586/ERD.12.91
dc.identifier.issn1743-4440
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2352
dc.language.isoeng
dc.publisherEXPERT REVIEWS
dc.relation.ispartofExpert Review of Medical Devices
dc.rightsrestrictedAccess
dc.rights.holderCopyright EXPERT REVIEWS
dc.subjectangioplasty
dc.subjectatherosclerosis
dc.subjectbiodegradable
dc.subjectcoronary
dc.subjectrestenosis
dc.subjectstent
dc.subject.otherpaint randomized-trial
dc.subject.otherfollow-up
dc.subject.otherbiodegradable polymers
dc.subject.otherbare metal
dc.subject.otherimplantation
dc.subject.otherpaclitaxel
dc.subject.otherthrombosis
dc.subject.otherdisease
dc.subject.otherlactide
dc.subject.other1-year
dc.subject.wosEngineering, Biomedical
dc.titleThe Supralimus (R) sirolimus-eluting stent
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBIENERT, Igor:Univ Sao Paulo, Sch Med, Dept Intervent Cardiol, Heart Inst InCor, Sao Paulo, Brazil; Marilia State Sch Med, Dept Intervent Cardiol, Sao Paulo, Brazil
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcPEDRO ALVES LEMOS NETO
hcfmusp.description.beginpage295
hcfmusp.description.endpage300
hcfmusp.description.issue3
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed23597097
hcfmusp.origem.scopus2-s2.0-84877897256
hcfmusp.origem.wosWOS:000319048400009
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
hcfmusp.relation.referenceBaran KW, 2011, EUROINTERVENTION, V6, P949, DOI 10.4244/EIJV6I8A165
hcfmusp.relation.referenceChin WWL, 2008, EUR J PHARM BIOPHARM, V69, P1083, DOI 10.1016/j.ejpb.2008.02.013
hcfmusp.relation.referenceCosta Jr JR, 2010, J AM COLL CARDIOL, V55, pA208
hcfmusp.relation.referenceDani Sameer, 2008, EuroIntervention, V4, P59, DOI 10.4244/EIJV4I1A11
hcfmusp.relation.referenceFaxon DP, 2004, CIRCULATION, V109, P2595, DOI 10.1161/01.CIR.0000128517.52533.DB
hcfmusp.relation.referenceHu XX, 2008, BIOMATERIALS, V29, P3128, DOI 10.1016/j.biomaterials.2008.04.010
hcfmusp.relation.referenceLemos PA, 2009, ARQ BRAS CARDIOL, V93, P590, DOI 10.1590/S0066-782X2009001200006
hcfmusp.relation.referenceLemos PA, 2004, CIRCULATION, V110, P3199, DOI 10.1161/01.CIR.0000147275.50550.68
hcfmusp.relation.referenceLemos PA, 2012, EUROINTERVENTION, V8, P117, DOI 10.4244/EIJV8I1A18
hcfmusp.relation.referenceLemos PA, 2009, CATHETER CARDIO INTE, V74, P665, DOI 10.1002/ccd.22166
hcfmusp.relation.referenceLima KM, 1999, BRAZ J MED BIOL RES, V32, P171
hcfmusp.relation.referenceLiu XH, 2005, J BIOMED MATER RES A, V74A, P84, DOI 10.1002/jbm.a.30367
hcfmusp.relation.referenceMiddleton JC, 2000, BIOMATERIALS, V21, P2335, DOI 10.1016/S0142-9612(00)00101-0
hcfmusp.relation.referenceOng ATL, 2006, EUR HEART J, V27, P2996, DOI 10.1093/eurheartj/ehl357
hcfmusp.relation.referenceSerruys PW, 2007, CIRCULATION, V115, P1433, DOI 10.1161/CIRCULATIONAHA.106.666826
hcfmusp.relation.referenceStone GW, 2007, NEW ENGL J MED, V356, P998, DOI 10.1056/NEJMoa067193
hcfmusp.relation.referenceThakkar Ashok, 2013, Journal of Medical Devices, V7, DOI 10.1115/1.4023414
hcfmusp.relation.referencevan Domburg RT, 2005, EUR HEART J, V26, P675, DOI 10.1093/eurheartj/ehi088
hcfmusp.relation.referenceWykrzykowska J, 2011, EUROINTERVENTION, V7, P789, DOI 10.4244/EIJV7I7A125
hcfmusp.relation.referenceXu J, 2011, INT J CHEM, V3, P57
hcfmusp.relation.referenceZhou ZH, 2009, POLYM-PLAST TECHNOL, V48, P115, DOI 10.1080/03602550802497206
hcfmusp.scopus.lastupdate2024-05-17
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