Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse

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art_BOUCHARD_Personalized_Preventive_Medicine_Genetics_and_the_Response_to_2015.PDF (747.62 KB)
Citações na Scopus
58
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
W B SAUNDERS CO-ELSEVIER INC
Autores
BOUCHARD, Claude
ASHLEY, Euan A.
FRANKLIN, Nina
HWANG, Paul M.
MATTSSON, C. Mikael
PHILLIPS, Shane A.
SARZYNSKI, Mark A.
WANG, Ping-yuan
Citação
PROGRESS IN CARDIOVASCULAR DISEASES, v.57, n.4, p.337-346, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications.
Palavras-chave
Personalized medicine, Individual differences, Genetics, Mitochondria, Endothelium
URI
https://observatorio.fm.usp.br/handle/OPI/9557
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03