LIGIA DE MORAES ANTUNES CORREA
Projetos de Pesquisa
Unidades Organizacionais
25 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 25
- Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction(2021) GUIMARAES, Guilherme Veiga; RIBEIRO, Fernando; CASTRO, Rafael Ertner; ROQUE, Jean Marcelo; MACHADO, Alexander Douglas Teixeira; ANTUNES-CORREA, Ligia M.; FERREIRA, Silvia Ayub; BOCCHI, Edimar AlcidesAims: Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF patients. Methods and results: HF patients with ejection fraction <= 40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIPS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 +/- 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 +/- 20.4 to 15.7 +/- 9.0 mu mol, p = 0.01), Deoxi-Hb (from 16.3 +/- 8.2 to 12.2 +/- 6.0 mu mol, p = 0.003) and HbT (from 45.7 +/- 27.6 to 27.7 +/- 13.4 mu mol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group. Conclusion: Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity.
conferenceObject Effects of Aerobic and Inspiratory Training on Skeletal Muscle Microrna-1 and Downstream-Associated Pathways in Patients With Systolic Heart Failure(2019) ANTUNES-CORREA, Ligia M.; TREVIZAN, Patricia; BACURAU, Aline V.; FERREIRA-SANTOS, Larissa; GOMES, Joao L.; URIAS, Ursula; OLIVEIRA, Patricia; ALVES, Maria-Janieire N.; ALMEIDA, Dirceu R.; BRUM, Patricia C.; OLIVEIRA, Edilamar M.; HAJJAR, Ludhmila; KALIL FILHO, Roberto; NEGRAO, Carlos E.- Maximal oxygen uptake: New and more accurate predictive equation(2018) ANTUNES-CORREA, Ligia M.
- Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients(2015) GROEHS, Raphaela V.; TOSCHI-DIAS, Edgar; ANTUNES-CORREA, Ligia M.; TREVIZAN, Patricia F.; RONDON, Maria Urbana P. B.; OLIVEIRA, Patricia; ALVES, Maria J. N. N.; ALMEIDA, Dirceu R.; MIDDLEKAUFF, Holly R.; NEGRAO, Carlos E.Arterial baroreflex control of muscle sympathetic nerve activity (ABRMSNA) is impaired in chronic systolic heart failure (CHF). The purpose of the study was to test the hypothesis that exercise training would improve the gain and reduce the time delay of ABRMSNA in CHF patients. Twenty-six CHF patients, New York Heart Association Functional Class II-III, EF <= 40%, peak (V) over dot O-2 <= 20 ml.kg(-1).min(-1) were divided into two groups: untrained (UT, n = 13, 57 +/- 3 years) and exercise trained (ET, n = 13, 49 +/- 3 years). Muscle sympathetic nerve activity (MSNA) was directly recorded by microneurography technique. Arterial pressure was measured on a beat-to-beat basis. Time series of MSNA and systolic arterial pressure were analyzed by autoregressive spectral analysis. The gain and time delay of ABRMSNA was obtained by bivariate autoregressive analysis. Exercise training was performed on a cycle ergometer at moderate intensity, three 60-min sessions per week for 16 wk. Baseline MSNA, gain and time delay of ABRMSNA, and low frequency of MSNA (LFMSNA) to high-frequency ratio (HFMSNA) (LFMSNA/HFMSNA) were similar between groups. ET significantly decreased MSNA. MSNA was unchanged in the UT patients. The gain and time delay of ABRMSNA were unchanged in the ET patients. In contrast, the gain of ABRMSNA was significantly reduced [3.5 +/- 0.7 vs. 1.8 +/- 0.2, arbitrary units (au)/mmHg, P = 0.04] and the time delay of ABRMSNA was significantly increased (4.6 +/- 0.8 vs. 7.9 +/- 1.0 s, P = 0.05) in the UT patients. LFMSNA-to-HFMSNA ratio tended to be lower in the ET patients (P < 0.08). Exercise training prevents the deterioration of ABRMSNA in CHF patients.
conferenceObject Exercise Training Restores Muscle Mechano and Metaboreflex Sensitivity in Heart Failure Patients(2013) ANTUNES-CORREA, Ligia M.; NOBRE, Thais S.; GROEHS, Raphaela V.; ALVES, Maria Janieire N. N.; RONDON, Maria Urbana P. B.; MADY, Charles; ALMEIDA, Dirceu R.; OLIVEIRA, Patricia; LIMA, Marta F.; MATHIAS, Wilson; BRUM, Patricia C.; ROSSONI, Luciana V.; OLIVEIRA, Edilamar M.; MIDDLEKAUFF, Holly R.; NEGRAO, Carlos EduardoIncreased sympathetic muscle mechanoreflex sensitivity and attenuated sympathetic muscle metaboreflex sensitivity have been described in heart failure (HF) patients. We tested the hypothesis that exercise training (ET) would improve sympathetic mechano and metaboreflex sensitivity in HF patients. 24 consecutive, randomized, HF patients, Functional Class II-III NYHA, EF≤40% were divided into two groups: Exercise-trained (n=12, 55±2 years) and untrained (n=12, 54±2 years). 10 normal controls (NC) were also studied. Muscle sympathetic nerve activity (MSNA) was directly recorded from the peroneal nerve. Mechanoreceptors were activated by passive exercise. Metaboreceptors were activated by post-exercise circulatory arrest. ET consisted of three 60-minutes exercise sessions per week for 4 months. ET significantly reduced MSNA in HF patients (34 vs. 40 bursts/min, P<0.05). ET significantly reduced MSNA responses to passive exercise ({Delta} = 2 vs. 5 bursts/min, P<0.05) and increased MNSA responses during post-exercise circulatory arrest ({Delta} = 5 vs. –1 bursts/min, P<0.0 5). These changes were so dramatic that the difference between HF patients and NC were no longer observed. No changes in untrained HF patients were found. In conclusion, ET restores sympathetic muscle mechano and metaboreflex sensitivity in HF patients, which may contribute to the reduction in MSNA and clinical outcomes in these patients.- Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure(2015) NEGRAO, Carlos E.; MIDDLEKAUFF, Holly R.; GOMES-SANTOS, Igor L.; ANTUNES-CORREA, Ligia M.Neurohormonal excitation and dyspnea are the hallmarks of heart failure (HF) and have long been associated with poor prognosis in HF patients. Sympathetic nerve activity (SNA) and ventilatory equivalent of carbon dioxide (VE/VO2) are elevated in moderate HF patients and increased even further in severe HF patients. The increase in SNA in HF patients is present regardless of age, sex, and etiology of systolic dysfunction. Neurohormonal activation is the major mediator of the peripheral vasoconstriction characteristic of HF patients. In addition, reduction in peripheral blood flow increases muscle inflammation, oxidative stress, and protein degradation, which is the essence of the skeletal myopathy and exercise intolerance in HF. Here we discuss the beneficial effects of exercise training on resting SNA in patients with systolic HF and its central and peripheral mechanisms of control. Furthermore, we discuss the exercise-mediated improvement in peripheral vasoconstriction in patients with HF. We will also focus on the effects of exercise training on ventilatory responses. Finally, we review the effects of exercise training on features of the skeletal myopathy in HF. In summary, exercise training plays an important role in HF, working synergistically with pharmacological therapies to ameliorate these abnormalities in clinical practice.
- Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients(2016) GROEHS, Raphaela V.; ANTUNES-CORREA, Ligia M.; NOBRE, Thais S.; ALVES, Maria-Janieire N. N.; RONDON, Maria Urbana P. B.; BARRETO, Antonio Carlos Pereira; NEGRAO, Carlos E.Background We investigated the effects of muscle functional electrical stimulation on muscle sympathetic nerve activity and muscle blood flow, and, in addition, exercise tolerance in hospitalised patients for stabilisation of heart failure. Methods Thirty patients hospitalised for treatment of decompensated heart failure, class IV New York Heart Association and ejection fraction30% were consecutively randomly assigned into two groups: functional electrical stimulation (n=15; 542 years) and control (n=15; 492 years). Muscle sympathetic nerve activity was directly recorded via microneurography and blood flow by venous occlusion plethysmography. Heart rate and blood pressure were evaluated on a beat-to-beat basis (Finometer), exercise tolerance by 6-minute walk test, quadriceps muscle strength by a dynamometer and quality of life by Minnesota questionnaire. Functional electrical stimulation consisted of stimulating the lower limbs at 10Hz frequency, 150ms pulse width and 70 mA intensity for 60minutes/day for 8-10 consecutive days. The control group underwent electrical stimulation at an intensity of<20 mA. Results Baseline characteristics were similar between groups, except age that was higher and C-reactive protein and forearm blood flow that were smaller in the functional electrical stimulation group. Functional electrical stimulation significantly decreased muscle sympathetic nerve activity and increased muscle blood flow and muscle strength. No changes were found in the control group. Walking distance and quality of life increased in both groups. However, these changes were greater in the functional electrical stimulation group. Conclusion Functional electrical stimulation improves muscle sympathetic nerve activity and vasoconstriction and increases exercise tolerance, muscle strength and quality of life in hospitalised heart failure patients. These findings suggest that functional electrical stimulation may be useful to hospitalised patients with decompensated chronic heart failure.
- Cardiac resynchronization therapy restores muscular metaboreflex control(2019) SPAGGIARI, Caio V.; KUNIYOSHI, Ricardo R.; ANTUNES-CORREA, Ligia M.; GROEHS, Raphaela V.; SIQUEIRA, Sergio F. de; MARTINELLI FILHO, MartinoIntroduction The muscular metaboreflex, whose activation regulates blood flow during isometric and aerobic exercise, is blunted in patients with heart failure (HF), and cardiac resynchronization therapy (CRT) may restore this regulatory reflex. Objective To evaluate metaboreflex responses after CRT. Methods Thirteen HF patients and 12 age-matched healthy control subjects underwent the following evaluations (pre- and post-CRT implantation in the patient group): (a) heart rate, blood pressure, and forearm blood flow measurements; (b) muscle sympathetic nerve activity (MSNA) evaluation; and (c) peak oxygen consumption (VO2peak). Examinations were performed at rest, during moderate isometric exercise (IE), and during forearm ischemia (metaboreflex activation). The primary outcome was the increment in MSNA during limb ischemia compared to the rest moment (Delta MSNA rest to metaboreflex activation). Results After CRT, rest MSNA decreased in the HF participants: 50.4 +/- 9.2 bursts/min pre-CRT vs 34.0 +/- 14.4 bursts/min post-CRT, P = .001, accompanied by an improvement in systolic blood pressure and in rate-pressure product. MSNA during limb ischemia decreased: 56.6 +/- 11.5 bursts/min pre-CRT vs 43.6 +/- 12.7 bursts/min post-CRT, P = .001, and the Delta MSNA rest to metaboreflex activation increased: 0% (interquartile range [IQR)], -7 to 9) vs 13% (IQR, 5-30), P = .03. An augmentation of mean blood pressure during limb ischemia post-CRT was noticed: 94 mmHg (IQR, 81-104) vs 110 mmHg (IQR, 100-117), P = .04. CRT improved VO2peak, and this improvement was correlated with diminution in Delta MSNA pre- to post-CRT at rest moment (r(s) = -0.74, P = .006). Conclusion CRT provides metaboreflex sensitization and MSNA enhancement. The restoration of sympathetic responsiveness correlates with the improvement in functional capacity.
- Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse(2015) BOUCHARD, Claude; ANTUNES-CORREA, Ligia M.; ASHLEY, Euan A.; FRANKLIN, Nina; HWANG, Paul M.; MATTSSON, C. Mikael; NEGRAO, Carlos E.; PHILLIPS, Shane A.; SARZYNSKI, Mark A.; WANG, Ping-yuan; WHEELER, Matthew T.Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications.
bookPart Exercicio fisico no controle autonômico em pacientes com insuficiência cardíaca(2019) ANTUNES-CORREA, Lígia de Moraes; UENO-PARDI, Linda Massako; NOBRE, Thaís Simões; FRAGA, Raffael Francisco Pires; ROLIM, Natale Pinheiro Lage; MIRANDA, Raphaela Vilar Ramalho Groehs; NEGRãO, Carlos Eduardo
- «
- 1 (current)
- 2
- 3
- »