Customized Photobiomodulation Modulates Pain and Alters Thermography Pattern in Patients with Knee Osteoarthritis: A Randomized Double-Blind Pilot Study

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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MARY ANN LIEBERT, INC
Autores
SOUSA, Marcelo Victor Pires de
FERREIRA, Nathalia Lopes
BRAGA, Natalia Almeida
ALDRED, Alexandre
GOMES, Guilherme
CHACUR, Marucia
Citação
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY, v.40, n.10, p.698-707, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Photobiomodulation therapy (PBMT) modulates a wide variety of biological processes, leading to anti-inflammatory and analgesic effects. Understanding the mechanisms underlying therapeutic effects of PBMT remains challenging due to varying outcomes observed between wavelengths, dosage, and site of application. Our research group has dedicated close attention to customization and individualization of dosimetry for PBMT protocols. Preliminary data showed that using an individualized treatment could solve contradictory results reported by previous studies. Based on literature and our preliminary data on light absorption, the goal of the present pilot is to determine whether our individualized dosimetry is a feasible method to assist osteoarthritis (OA) pain control. Methods: This parallel two-arm controlled-pilot study aimed to assess whether personalized PBMT can be effective in the treatment of painful chronic knee OA. Thirty-one patients were randomly allocated into treatment and placebo group (sham irradiation), and the treatment procedure was performed twice a week, for 5 weeks. The PBMT was applied using 850nm with continuous wave and a total of 526-1402J each session. Individualized dosimetry was chosen based on each patient's body mass index and skin color. Quality-of-life (QOL) questionnaires and serum/urine analyses were performed before and after treatment was over. Both examiners and participants were blinded to group allocation. Results: Pain scores were reduced significantly in the 4th, 5th, and 10th sessions and remained lower 6 weeks posttherapy in the treatment group when compared to the placebo group. Moreover, the treatment group's results were improved in QOL questionnaires score, dopamine level, and in microcirculation. Conclusions: The present results provide initial evidence that customized photobiomodulation (PBM) reduce pain levels in short- and medium-term in patients with symptomatic knee OA when compared to placebo group. Furthermore, we have provided evidence that customized PBM is able to improve the QOL of those patients.
Palavras-chave
analgesic, arthritis, photobiomodulation therapy, low-level laser therapy, quality of life, thermography
URI
https://observatorio.fm.usp.br/handle/OPI/54166
Referências
  1. Alqualo-Costa R, 2021, CLIN REHABIL, V35, P1413, DOI 10.1177/02692155211012004
  2. Attur M, 2020, ANN RHEUM DIS, V79, P400, DOI 10.1136/annrheumdis-2019-216055
  3. Bacon K, 2020, ANN RHEUM DIS, V79, P1105, DOI 10.1136/annrheumdis-2020-217363
  4. Bashkatov AN, 2005, OPT SPECTROSC+, V99, P836, DOI 10.1134/1.2135863
  5. Bjordal JM, 2004, BMJ-BRIT MED J, V329, P1317, DOI 10.1136/bmj.38273.626655.63
  6. Chow RT, 2016, PHOTOMED LASER SURG, V34, P599, DOI 10.1089/pho.2015.4048
  7. da Silva MM, 2018, LASER MED SCI, V33, P343, DOI 10.1007/s10103-017-2388-2
  8. de Oliveira ME, 2021, LASER MED SCI, V36, P1461, DOI 10.1007/s10103-020-03187-9
  9. Gomes CAFD, 2018, LASER SURG MED, V50, P819, DOI 10.1002/lsm.22939
  10. Denoble AE, 2010, CLIN MED INSIGHTS-AR, V3, P69, DOI 10.4137/CMAMD.S5916
  11. FELSON DT, 1987, ARTHRITIS RHEUM, V30, P914, DOI 10.1002/art.1780300811
  12. Ferraresi C, 2011, LASER MED SCI, V26, P349, DOI 10.1007/s10103-010-0855-0
  13. Fritsch CG, 2019, EUR J APPL PHYSIOL, V119, P279, DOI 10.1007/s00421-018-4023-8
  14. Gomes CAFD, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03293-3
  15. Hamblin MR, 2018, PHOTOCHEM PHOTOBIOL, V94, P199, DOI 10.1111/php.12864
  16. Hamblin MR, 2017, AIMS BIOPHYS, V4, P337, DOI 10.3934/biophy.2017.3.337
  17. Hamblin MR., HDB LOW LEVEL LASER
  18. Harper A, 1998, PSYCHOL MED, V28, P551, DOI 10.1017/S0033291798006667
  19. Hegedus B, 2009, PHOTOMED LASER SURG, V27, P577, DOI 10.1089/pho.2008.2297
  20. Hussain SM, 2016, SCOT MED J, V61, P7, DOI 10.1177/0036933015619588
  21. Hylands-White N, 2017, RHEUMATOL INT, V37, P29, DOI 10.1007/s00296-016-3481-8
  22. Kanakaris NK, 2015, J ORTHOP TRAUMA, V29, pS10, DOI [10.1097/BOT.0000000000000286, 10.1097/BOT.0000000000000465]
  23. Kloppenburg M, 2020, OSTEOARTHR CARTILAGE, V28, P242, DOI 10.1016/j.joca.2020.01.002
  24. Laakso EL, 2017, PHOTOMED LASER SURG, V35, P1, DOI 10.1089/pho.2016.4218
  25. Langella LG, 2018, LASER MED SCI, V33, P1933, DOI 10.1007/s10103-018-2558-x
  26. Lasanen R, 2015, PHYSIOL MEAS, V36, P273, DOI 10.1088/0967-3334/36/2/273
  27. Leal MVD, 2020, PHOTOBIOMOD PHOTOMED, V38, P138, DOI 10.1089/photob.2019.4714
  28. Min S, 2015, J ALTERN COMPLEM MED, V21, P46, DOI 10.1089/acm.2013.0442
  29. Oliveira CG, 2020, PHOTOCH PHOTOBIO SCI, V19, P1392, DOI 10.1039/d0pp00037j
  30. Palamoni OP, 2022, PROC SPIE, V12147, DOI 10.1117/12.2621670
  31. de Sousa MVP, 2018, J BIOPHOTONICS, V11, DOI 10.1002/jbio.201700370
  32. Rodrigues AD, 2020, LASER MED SCI, V35, P447, DOI 10.1007/s10103-019-02842-0
  33. Roos Ewa M, 2003, Health Qual Life Outcomes, V1, P17, DOI 10.1186/1477-7525-1-17
  34. Sah DWY, 2003, NAT REV DRUG DISCOV, V2, P460, DOI 10.1038/nrd1107
  35. Souza-Barros L, 2018, LASER SURG MED, V50, P291, DOI 10.1002/lsm.22760
  36. Spalding SJ, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2360
  37. Stausholm MB, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-031142
  38. Tomazoni SS, 2016, J BIOMED OPT, V21, DOI 10.1117/1.JBO.21.10.108001
  39. Treister R, 2011, J PAIN, V12, P875, DOI 10.1016/j.jpain.2011.02.348
  40. Vassao PG, 2021, LASER MED SCI, V36, P1341, DOI 10.1007/s10103-020-03223-8
  41. Vassao PG, 2020, LASER MED SCI, V35, P139, DOI 10.1007/s10103-019-02807-3
  42. Viisanen H, 2012, BRAIN RES BULL, V89, P133, DOI 10.1016/j.brainresbull.2012.08.002
  43. Wallace IJ, 2017, P NATL ACAD SCI USA, V114, P9332, DOI 10.1073/pnas.1703856114
  44. Wood Patrick B, 2008, Expert Rev Neurother, V8, P781, DOI 10.1586/14737175.8.5.781
  45. Zhang W, 2007, OSTEOARTHR CARTILAGE, V15, P981, DOI 10.1016/j.joca.2007.06.014

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/08