Survival analysis of young adults from a Brazilian cohort of non-small cell lung cancer patients
Carregando...
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
CANCER INTELLIGENCE LTD
Autores
LUIZAGA, Carolina Terra de Moraes
RIBEIRO, Karina Braga
Citação
ECANCERMEDICALSCIENCE, v.15, article ID 1279, 15p, 2021
Resumo
Background: The influence of age at diagnosis in non-small cell lung cancer (NSCLC) prognosis is unclear. Objectives: To compare in a Brazilian cohort of NSCLC patients of different age groups: 1) The overall survival; 2) Clinical features and treatment options. Methods: This is a retrospective cohort study using a hospital-based registry, for NSCLC patients registered in years 2000-2009. Patients were grouped into three age groups: Young adults (YA: < 40 years), middle-aged (MA: 40-64 years) and elderly (E: >= 65 years). Kaplan-Meier was used to estimate overall survival and Cox regression for hazard ratios (HRs) and 95% confidence intervals. Results: 17,422 NSCLC patients were included: 370 YA (2.1%), 8,697 MA (49.9%) and 8,355 E (48.0%). Compared with older age groups, the YA group had a higher proportion of females, patients diagnosed with adenocarcinoma and metastatic disease (63.2%). Overall survival was longer in YA in the entire cohort and in all clinical stages (CSs) (p < 0.001). For YA, higher education level was a good prognosis factor (compared with illiterate and incomplete elementary); advanced or metastatic disease (compared with early-stage disease) and treatment based in radiotherapy or chemotherapy (CT) (without surgery), compared with treatment combinations with surgery, were poor prognostic factors. Young men (but not women) had lower HR of death compared with older groups; YA had lower HR of death in all CSs compared with patients from older groups. A higher percentage of YA were treated with surgery or CT in early-stage disease compared with older groups. Besides that, YA and MA patients treated with surgery or CT had a better prognosis than elderlies. Conclusions: In this Brazilian cohort of NSCLC patients, most young individuals were diagnosed with metastatic disease. YA presented longer survival than older age groups in all CSs, but mainly in CS I/II and III, where some patients may achieve long remissions or cure.
Palavras-chave
lung carcinoma, non-small cell lung cancer, young adult, survival, clinical features
Referências
- Ak G, 2007, LUNG, V185, P279, DOI 10.1007/s00408-007-9021-2
- Albano JD, 2007, JNCI-J NATL CANCER I, V99, P1384, DOI 10.1093/jnci/djm127
- [Anonymous], 2015, WHY SAO PAULO
- [Anonymous], 2020, DIRETRIZES ESTRATEGI
- [Anonymous], 2020, UNIDADES HABILITADAS
- [Anonymous], 2013, SAO PAULO ESTADO COM
- [Anonymous], 2020, ESTIMATIVA INCIDENCI
- Araujo LH, 2018, J BRAS PNEUMOL, V44, P55, DOI [10.1590/s1806-37562017000000135, 10.1590/S1806-37562017000000135]
- Arnold BN, 2016, J THORAC ONCOL, V11, P1121, DOI 10.1016/j.jtho.2016.03.023
- Bleyer A, 2008, NAT REV CANCER, V8, P288, DOI 10.1038/nrc2349
- Cancer Research UK, 2020, CANC STAT REP UK
- Costa GJ, 2018, LUNG CANCER, V125, P77, DOI 10.1016/j.lungcan.2018.09.005
- Cronemberger E, 2020, NSCLC CLIN, V75, P1980, DOI [10.6061/clinics/2020/e1777, DOI 10.6061/CLINICS/2020/E1777]
- Fang S, 2014, DRUG DES DEV THER, V8, P1595, DOI 10.2147/DDDT.S69690
- Franceschini JP, 2017, J BRAS PNEUMOL, V43, P431, DOI [10.1590/S1806-37562016000000298, 10.1590/s1806-37562016000000298]
- Handforth C, 2015, ANN ONCOL, V26, P1091, DOI 10.1093/annonc/mdu540
- INCA, OBS POL NAC CONTR TO
- Jiang W, 2012, CHINESE MED J-PEKING, V125, P72, DOI 10.3760/cma.j.issn.0366-6999.2012.01.014
- Mauri D, 2006, ANTICANCER RES, V26, P3175
- Radzikowska E, 2001, LUNG CANCER, V33, P203, DOI 10.1016/S0169-5002(01)00199-4
- Ramalingam S, 1998, J CLIN ONCOL, V16, P651, DOI 10.1200/JCO.1998.16.2.651
- Ribeiro K, 2015, INT J EPIDEMIOL, V44, P3
- Rich AL, 2015, QJM-INT J MED, V108, P891, DOI 10.1093/qjmed/hcv052
- Siegel RL, 2016, CA-CANCER J CLIN, V66, P7, DOI 10.3322/caac.21332
- Subramanian J, 2010, J THORAC ONCOL, V5, P23, DOI 10.1097/JTO.0b013e3181c41e8d
- Suidan AM, 2019, J GLOB ONCOL, V5, P1, DOI 10.1200/JGO.18.00216
- Tian DL, 2003, LUNG CANCER-J IASLC, V42, P215, DOI 10.1016/S0169-5002(03)00286-1
- Tominaga K, 1999, JPN J CANCER RES, V90, P490, DOI 10.1111/j.1349-7006.1999.tb00774.x
- United Nations Department of Economic and Social Affairs Population Division, 2019, WORLD POP AG 2019 HI
- Cormedi MCV, 2018, CLINICS, V73, DOI 10.6061/clinics/2018/e656s
- Ye T, 2014, J THORAC DIS, V6, P1396, DOI 10.3978/j.issn.2072-1439.2014.08.50
Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/38
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/38