https://observatorio.fm.usp.br/handle/OPI/11686
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | OLIVEIRA, Marcos C. B. | - |
dc.contributor.author | SATO, Douglas Kazutoshi | - |
dc.contributor.author | SOARES-NETO, Herval R. | - |
dc.contributor.author | LUCATO, Leandro T. | - |
dc.contributor.author | CALLEGARO, Dagoberto | - |
dc.contributor.author | NITRINI, Ricardo | - |
dc.contributor.author | MEDEIROS, Raphael S. S. | - |
dc.contributor.author | MISU, Tatsuro | - |
dc.contributor.author | FUJIHARA, Kazuo | - |
dc.contributor.author | CASTRO, Luiz H. | - |
dc.date.accessioned | 2015-10-26T16:28:28Z | - |
dc.date.available | 2015-10-26T16:28:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | BMC NEUROLOGY, v.15, article ID 159, 6p, 2015 | - |
dc.identifier.issn | 1471-2377 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/11686 | - |
dc.description.abstract | Background: Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies. Case report: We report the case of a Hispanic 64-year-old woman with cognitive decline and extensive leukoencephalopathy. Magnetic resonance imaging revealed white-matter lesions with increased water diffusivity, without blood-brain-barrier disruption. Brain biopsy showed tissue rarefaction with vacuolation, mild inflammation, few reactive astrocytes and decreased aquaporin water-channel expression in the lesions. Six months later, she was diagnosed with atypical mycobacterial pulmonary infection. Brain lesions resolved after antimycobacterial treatment. Conclusion: We hypothesize leukoencephalopathic changes and vasogenic edema were associated with decreased aquaporin expression. Further studies should clarify if reversible leukoencephalopathy has a causal relationship with decreased aquaporin expression and atypical mycobacterial infection, and mechanisms underlying leukoencephalopathy resolution after antimycobacterial treatment. This article may contribute to the understanding of pathogenic mechanisms underlying magnetic resonance imaging subcortical lesions and edema, which remain incompletely understood. | - |
dc.description.sponsorship | KAKENHI of The Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [22229008] | - |
dc.description.sponsorship | Ministry of Health, Labor and Welfare of Japan | - |
dc.language.iso | eng | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.ispartof | BMC Neurology | - |
dc.rights | openAccess | - |
dc.subject | Reversible encephalopathy syndrome | - |
dc.subject | PRES | - |
dc.subject | Mycobacteriosis | - |
dc.subject | Leukoencephalopathy | - |
dc.subject | Vasogenic edema | - |
dc.subject | Aquaporin water-channel | - |
dc.subject.other | reversible encephalopathy syndrome | - |
dc.subject.other | tuberculous encephalopathy | - |
dc.subject.other | encephalomyelitis | - |
dc.subject.other | meningitis | - |
dc.subject.other | pathology | - |
dc.subject.other | pathogenesis | - |
dc.subject.other | spectrum | - |
dc.title | Leukoencephalopathy resolution after atypical mycobacterial treatment: a case report | - |
dc.type | article | - |
dc.rights.holder | Copyright BIOMED CENTRAL LTD | - |
dc.identifier.doi | 10.1186/s12883-015-0415-0 | - |
dc.identifier.pmid | 26329680 | - |
dc.subject.wos | Clinical Neurology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SATO, Douglas Kazutoshi:Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808575, Japan | - |
hcfmusp.author.external | MISU, Tatsuro:Tohoku Univ, Sch Med, Dept Multiple Sclerosis Therapeut, Sendai, Miyagi 9808575, Japan | - |
hcfmusp.author.external | FUJIHARA, Kazuo:Tohoku Univ, Sch Med, Dept Multiple Sclerosis Therapeut, Sendai, Miyagi 9808575, Japan | - |
hcfmusp.description.articlenumber | 159 | - |
hcfmusp.description.volume | 15 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84940499708 | - |
hcfmusp.origem.id | WOS:000360617700002 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 1 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - LIM/15 Artigos e Materiais de Revistas Científicas - LIM/44 Artigos e Materiais de Revistas Científicas - LIM/45 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_OLIVEIRA_Leukoencephalopathy_resolution_after_atypical_mycobacterial_treatment_a_case_2015.PDF | publishedVersion (English) | 3.62 MB | Adobe PDF | View/Open |
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