Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome

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art_LANDEROS-WEISENBERGER_Randomized_Sham_Controlled_Doubleblind_Trial_of_Repetitive_Transcranial_2015.PDF (416.22 KB)
Citações na Scopus
60
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
LANDEROS-WEISENBERGER, Angeli
MANTOVANI, Antonio
MOTLAGH, Maria G.
KATSOVICH, Liliya
LECKMAN, James F.
LISANBY, Sarah H.
Citação
BRAIN STIMULATION, v.8, n.3, p.574-581, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: A small proportion of individuals with Tourette syndrome (TS) have a lifelong course of illness that fails to respond to conventional treatments. Open label studies have suggested that low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) targeting the supplementary motor area (SMA) may be effective in reducing tic severity. Objective/Hypothesis: To examine the efficacy of rTMS over the SMA for TS in a randomized double-blind sham-controlled trial (RCT). Methods: We conducted a two-site RCT-rTMS with 20 adults with severe TS for 3 weeks. Treatment consisted of 15 sessions (1-Hz; 30 min; 1800 pulses per day) of active or sham rTMS at 110% of the motor threshold over the SMA. A subsequent 3 week course of active rTMS treatment was offered. Results: Of the 20 patients (16 males; mean age of 33.7 + 12.2 years), 9 received active and 11 received sham rTMS. After 3 weeks, patients receiving active rTMS showed on average a 17.3% reduction in the YGTSS total tic score compared to a 13.2% reduction in those receiving sham rTMS, resulting in no statistically significant reduction in tic severity (P = 0.27). An additional 3 week open label active treatment for those patients (n = 7) initially randomized to active rTMS resulted in a significant overall 29.7% reduction in tic severity compared to baseline (P = 0.04). Conclusion: This RCT did not demonstrate efficacy of 3-week SMA-targeted low frequency rTMS in the treatment of severe adult TS. Further studies using longer or alternative stimulation protocols are warranted.
Palavras-chave
Tourette syndrome, Transcranial, Magnetic stimulation, Randomized controlled trial
URI
https://observatorio.fm.usp.br/handle/OPI/11859
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/21