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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | GRANGEIRO, Alexandre | - |
dc.contributor.author | COUTO, Marcia Thereza | - |
dc.contributor.author | PERES, Maria Fernanda | - |
dc.contributor.author | LUIZ, Olinda | - |
dc.contributor.author | ZUCCHI, Eliana Miura | - |
dc.contributor.author | CASTILHO, Euclides Ayres de | - |
dc.contributor.author | ESTEVAM, Denize Lotufo | - |
dc.contributor.author | ALENCAR, Rosa | - |
dc.contributor.author | WOLFFENBUETTEL, Karina | - |
dc.contributor.author | ESCUDER, Maria Mercedes | - |
dc.contributor.author | CALAZANS, Gabriela | - |
dc.contributor.author | FERRAZ, Dulce | - |
dc.contributor.author | ARRUDA, Erico | - |
dc.contributor.author | CORREA, Maria da Gloria | - |
dc.contributor.author | AMARAL, Fabiana Rezende | - |
dc.contributor.author | SANTOS, Juliane Cardoso Villela | - |
dc.contributor.author | ALVAREZ, Vivian Salles | - |
dc.contributor.author | KIETZMANN, Tiago | - |
dc.date.accessioned | 2015-12-10T16:49:18Z | - |
dc.date.available | 2015-12-10T16:49:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | BMJ OPEN, v.5, n.8, article ID e009021, 11p, 2015 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/12436 | - |
dc.description.abstract | Introduction: Few results from programmes based on combination prevention methods are available. We propose to analyse the degree of protection provided by postexposure prophylaxis (PEP) for consensual sexual activity at healthcare clinics, its compensatory effects on sexual behaviour; and the effectiveness of combination prevention methods and pre-exposure prophylaxis (PrEP), compared with exclusively using traditional methods. Methods and analysis: A total of 3200 individuals aged 16 years or older presenting for PEP at 5 sexually transmitted disease (STD)/HIV clinics in 3 regions of Brazil will be allocated to one of two groups: the PEP group-individuals who come to the clinic within 72 h after a sexual exposure and start PEP; and the non-PEP group-individuals who come after 72 h but within 30 days of exposure and do not start PEP. Clinical follow-up will be conducted initially for 6 months and comprise educational interventions based on information and counselling for using prevention methods, including PrEP. In the second study phase, individuals who remain HIV negative will be regrouped according to the reported use of prevention methods and observed for 18 months: only traditional methods; combined methods; and PrEP. Effectiveness will be analysed according to the incidence of HIV, syphilis and hepatitis B and C and protected sexual behaviour. A structured questionnaire will be administered to participants at baseline and every 6 months thereafter. Qualitative methods will be employed to provide a comprehensive understanding of PEP-seeking behaviour, preventive choices and exposure to HIV. Ethics and dissemination: This study will be conducted in accordance with the resolution of the School of Medicine Research Ethics Commission of Universidade de Sao Paulo (protocol no. 251/14). The databases will be available for specific studies, after management committee approval. Findings will be presented to researchers, health managers and civil society members by means of newspapers, electronic media and scientific journals and meetings. | - |
dc.description.sponsorship | Brazilian Ministry of Health [SVS-MS 01-2012, 027941/2012] | - |
dc.description.sponsorship | National Council for Scientific and Technological Development [MCTI/CNPQ/UNIVERSAL 14/2014] | - |
dc.language.iso | eng | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.relation.ispartof | BMJ Open | - |
dc.rights | openAccess | - |
dc.subject.other | sexual risk behavior | - |
dc.subject.other | homosexual-men | - |
dc.subject.other | follow-up | - |
dc.subject.other | gay men | - |
dc.subject.other | antiretroviral therapy | - |
dc.subject.other | heterosexual men | - |
dc.subject.other | exposure | - |
dc.subject.other | cohort | - |
dc.subject.other | infection | - |
dc.subject.other | transmission | - |
dc.title | Pre-exposure and postexposure prophylaxes and the combination HIV prevention methods (The Combine! Study): protocol for a pragmatic clinical trial at public healthcare clinics in Brazil | - |
dc.type | article | - |
dc.rights.holder | Copyright BMJ PUBLISHING GROUP | - |
dc.identifier.doi | 10.1136/bmjopen-2015-009021 | - |
dc.identifier.pmid | 26307622 | - |
dc.subject.wos | Medicine, General & Internal | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ZUCCHI, Eliana Miura:Univ Catolica Santos, Programa Posgrad Saude Colet, Sao Paulo, Brazil | - |
hcfmusp.author.external | ESTEVAM, Denize Lotufo:Secretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids, Sao Paulo, Brazil | - |
hcfmusp.author.external | ALENCAR, Rosa:Secretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids, Sao Paulo, Brazil | - |
hcfmusp.author.external | WOLFFENBUETTEL, Karina:Secretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids, Sao Paulo, Brazil | - |
hcfmusp.author.external | ESCUDER, Maria Mercedes:Secretaria Estado Saude Sao Paulo, Inst Saude, Sao Paulo, Brazil | - |
hcfmusp.author.external | ARRUDA, Erico:Secretaria Estado Saude Ceara, Hosp Sao Jose, Fortaleza, Ceara, Brazil | - |
hcfmusp.author.external | CORREA, Maria da Gloria:Secretaria Municipal Saude Porto Alegre, Serv Atendimento Especializado Doencas Sexualment, Porto Alegre, RS, Brazil | - |
hcfmusp.author.external | AMARAL, Fabiana Rezende:Secretaria Municipal Saude Ribeirao Preto, Ctr Referencia Especialidades Cent, Ribeirao Preto, Brazil | - |
hcfmusp.author.external | SANTOS, Juliane Cardoso Villela:Secretaria Municipal Saude Curitiba, Ctr Orientacao & Aconselhamento, Curitiba, Parana, Brazil | - |
hcfmusp.description.articlenumber | e009021 | - |
hcfmusp.description.issue | 8 | - |
hcfmusp.description.volume | 5 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000363479100081 | - |
hcfmusp.origem.id | 2-s2.0-84941559284 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 19 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 Artigos e Materiais de Revistas Científicas - LIM/39 Artigos e Materiais de Revistas Científicas - ODS/03 Artigos e Materiais de Revistas Científicas - ODS/05 |
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