Galectin-3 Determines Tumor Cell Adaptive Strategies in Stressed Tumor Microenvironments
Carregando...
Citações na Scopus
68
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Citação
FRONTIERS IN ONCOLOGY, v.6, article ID 127, 12p, 2016
Resumo
Galectin-3 is a member of the beta-galactoside-binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein found in the nucleus and in the cytoplasm, under certain conditions, galectin-3 can be secreted by an yet unknown mechanism. Under stressing conditions (e.g., hypoxia and nutrient deprivation) galectin-3 is upregulated, through the activity of transcription factors, such as HIF-1 alpha and NF-kappa B. Here, we review evidence that indicates a positive role for galectin-3 in MAPK family signal transduction, leading to cell proliferation and cell survival. Galectin-3 serves as a scaffold protein, which favors the spatial organization of signaling proteins as K-RAS. Upon secretion, extracellular galectin-3 interacts with a variety of cell surface glycoproteins, such as growth factor receptors, integrins, cadherins, and members of the Notch family, among other glycoproteins, besides different extracellular matrix molecules. Through its ability to oligomerize, galectin-3 forms lectin lattices that act as scaffolds that sustain the spatial organization of signaling receptors on the cell surface, dictating its maintenance on the plasma membrane or their endocytosis. Galectin-3 induces tumor cell, endothelial cell, and leukocyte migration, favoring either the exit of tumor cells from a stressed microenvironment or the entry of endothelial cells and leukocytes, such as monocytes/macrophages into the tumor organoid. Therefore, galectin-3 plays homeostatic roles in tumors, as (i) it favors tumor cell adaptation for survival in stressed conditions; (ii) upon secretion, galectin-3 induces tumor cell detachment and migration; and (iii) it attracts monocyte/macrophage and endothelial cells to the tumor mass, inducing both directly and indirectly the process of angiogenesis. The two latter activities are potentially targetable, and specific interventions may be designed to counteract the protumoral role of extracellular galectin-3.
Palavras-chave
galectin-3, cell signaling, migration, angiogenesis, tumor microenvironment
Referências
- Ahmad N, 2004, J BIOL CHEM, V279, P10841, DOI 10.1074/jbc.M312834200
- Sano H, 2000, J IMMUNOL, V165, P2156
- Kadrofske MM, 1998, ARCH BIOCHEM BIOPHYS, V349, P7, DOI 10.1006/abbi.1997.0447
- Mourad-Zeidan AA, 2008, AM J PATHOL, V173, P1839, DOI 10.2353/ajpath.2008.080380
- Dumic J, 2000, CELL PHYSIOL BIOCHEM, V10, P149, DOI 10.1159/000016345
- Park GB, 2015, INT J ONCOL, V46, P185, DOI 10.3892/ijo.2014.2721
- SATO S, 1992, J BIOL CHEM, V267, P6983
- Davidson PJ, 2002, GLYCOBIOLOGY, V12, P329, DOI 10.1093/glycob/12.5.329
- Krzeminski M, 2011, BBA-GEN SUBJECTS, V1810, P150, DOI 10.1016/j.bbagen.2010.11.001
- Li SY, 2006, GLYCOBIOLOGY, V16, P612, DOI 10.1093/glycob/cwj089
- Lau KS, 2007, CELL, V129, P123, DOI 10.1016/j.cell.2007.01.049
- Sun W, 2015, MOL PHARMACEUT, V12, P4124, DOI 10.1021/acs.molpharmaceut.5b00568
- Seberger PJ, 1999, GLYCOBIOLOGY, V9, P235, DOI 10.1093/glycob/9.3.235
- Poirier O, 2001, DIABETES, V50, P1214, DOI 10.2337/diabetes.50.5.1214
- Guardia CMA, 2011, J CHEM INF MODEL, V51, P1918, DOI 10.1021/ci200180h
- Gao XG, 2014, ONCOTARGET, V5, P2077
- Thery C, 2001, J IMMUNOL, V166, P7309
- Patterson RJ, 2015, METHODS MOL BIOL, V1207, P431, DOI 10.1007/978-1-4939-1396-1_28
- Gaudin JC, 2000, BIOL CELL, V92, P49, DOI 10.1016/S0248-4900(00)88763-8
- Shekhar MPV, 2004, AM J PATHOL, V165, P1931, DOI 10.1016/S0002-9440(10)63245-2
- Demetriou M, 2001, NATURE, V409, P733, DOI 10.1038/35055582
- BARONDES SH, 1994, J BIOL CHEM, V269, P20807
- LOBSANOV YD, 1993, J BIOL CHEM, V268, P27034
- Arnoys EJ, 2015, METHODS MOL BIOL, V1207, P465, DOI 10.1007/978-1-4939-1396-1_30
- Shankar J, 2012, J PATHOL, V228, P56, DOI 10.1002/path.4041
- Menon S, 2011, BIOCHEM BIOPH RES CO, V410, P91, DOI 10.1016/j.bbrc.2011.05.112
- Boscher C, 2013, MOL BIOL CELL, V24, P2134, DOI 10.1091/mbc.E13-02-0095
- Lajoie P, 2009, J CELL BIOL, V185, P381, DOI 10.1083/jcb.200811059
- Nangia-Makker P, 2010, INT J CANCER, V127, P2530, DOI 10.1002/ijc.25254
- Mazurek N, 2000, J BIOL CHEM, V275, P36311, DOI 10.1074/jbc.M003831200
- Cui GH, 2015, MED ONCOL, V32, DOI 10.1007/s12032-015-0570-6
- Allenspach EJ, 2002, CANCER BIOL THER, V1, P466
- Hsu YL, 2013, CARCINOGENESIS, V34, P1370, DOI 10.1093/carcin/bgt040
- Partridge EA, 2004, SCIENCE, V306, P120, DOI 10.1126/science.1102109
- Boscher C, 2011, CURR OPIN CELL BIOL, V23, P383, DOI 10.1016/j.ceb.2011.05.001
- Nangia-Makker P, 2000, AM J PATHOL, V156, P899, DOI 10.1016/S0002-9440(10)64959-0
- Zheng DT, 2014, ONCOL REP, V32, P411, DOI 10.3892/or.2014.3170
- MOUTSATSOS IK, 1987, P NATL ACAD SCI USA, V84, P6452, DOI 10.1073/pnas.84.18.6452
- COWLES EA, 1990, J BIOL CHEM, V265, P17706
- Neder L, 2004, BRAIN PATHOL, V14, P399
- de Oliveira JT, 2011, INT J DEV BIOL, V55, P823, DOI 10.1387/ijdb.113359jt
- Gilmore TD, 2006, ONCOGENE, V25, P6680, DOI 10.1038/sj.onc.1209954
- Liu FT, 2002, BBA-GEN SUBJECTS, V1572, P263, DOI 10.1016/S0304-4165(02)00313-6
- Akahani S, 1997, CANCER RES, V57, P5272
- Menon RP, 1999, EUR J BIOCHEM, V264, P569, DOI 10.1046/j.1432-1327.1999.00671.x
- Tsay YG, 1999, EXP CELL RES, V252, P250, DOI 10.1006/excr.1999.4643
- Gabius HJ, 2004, CHEMBIOCHEM, V5, P740, DOI 10.1002/cbic.200300753
- Bergers G, 2003, NAT REV CANCER, V3, P401, DOI 10.1038/nrc1093
- Liu L, 2004, BIOCHEM J, V380, P31, DOI 10.1042/BJ20031300
- Yoshii T, 2002, J BIOL CHEM, V277, P6852, DOI 10.1074/jbc.M107668200
- Openo KP, 2000, EXP CELL RES, V255, P278, DOI 10.1006/excr.1999.4782
- Bridges E, 2011, FUTURE ONCOL, V7, P569, DOI [10.2217/fon.11.20, 10.2217/FON.11.20]
- Granovsky M, 2000, NAT MED, V6, P306
- Vokhmyanina OA, 2012, GLYCOBIOLOGY, V22, P1207, DOI 10.1093/glycob/cws079
- Dange MC, 2015, MOL CELL BIOCHEM, V404, P79, DOI 10.1007/s11010-015-2367-5
- LIAO DI, 1994, P NATL ACAD SCI USA, V91, P1428, DOI 10.1073/pnas.91.4.1428
- Kobayashi T, 2011, INT J CANCER, V129, P2775, DOI 10.1002/ijc.25946
- Kuklinski S, 1998, J NEUROCHEM, V70, P814
- Morris S, 2004, GLYCOBIOLOGY, V14, P293, DOI 10.1093/glycob/cwh029
- Elad-Sfadia G, 2004, J BIOL CHEM, V279, P34922, DOI 10.1074/jbc.M312697200
- Carvalho RS, 2014, CANCER BIOL THER, V15, P840, DOI 10.4161/cbt.28873
- Rabinovich GA, 2007, CURR OPIN STRUC BIOL, V17, P513, DOI 10.1016/j.sbi.2007.09.002
- Nabi IR, 2015, J CELL SCI, V128, P2213, DOI 10.1242/jcs.151159
- Fukumori T, 2006, CANCER RES, V66, P3114, DOI 10.1158/0008-5472.CAN-05-3750
- Thijssen VL, 2015, BBA-REV CANCER, V1855, P235, DOI 10.1016/j.bbcan.2015.03.003
- Wang L, 2016, BIOMED PHARMACOTHER, V78, P165, DOI 10.1016/j.biopha.2016.01.014
- Funasaka T, 2014, SEMIN CANCER BIOL, V27, P30, DOI 10.1016/j.semcancer.2014.03.004
- Levy R, 2010, MOL CANCER THER, V9, P2208, DOI 10.1158/1535-7163.MCT-10-0262
- Meyer A, 2013, UROL ONCOL-SEMIN ORI, V31, P74, DOI 10.1016/j.urolonc.2010.09.011
- Ruvolo PP, 2016, BBA-MOL CELL RES, V1863, P427, DOI 10.1016/j.bbamcr.2015.08.008
- Andre S, 2010, MOL PHARMACEUT, V7, P2270, DOI 10.1021/mp1002416
- Davidson PJ, 2006, GLYCOBIOLOGY, V16, P602, DOI 10.1093/glycob/cwj088
- Mori Y, 2015, J BIOL CHEM, V290, P26125, DOI 10.1074/jbc.M115.651489
- Park JW, 2001, NUCLEIC ACIDS RES, V29, P3595, DOI 10.1093/nar/29.17.3595
- Suzuki O, 2015, INT J ONCOL, V47, P2091, DOI 10.3892/ijo.2015.3211
- Kim EK, 2010, BBA-MOL BASIS DIS, V1802, P396, DOI 10.1016/j.bbadis.2009.12.009
- Machado CML, 2014, CANCER MED-US, V3, P201, DOI 10.1002/cam4.173
- Nieminen J, 2007, J BIOL CHEM, V282, P1374, DOI 10.1074/jbc.M604506200
- HUFLEJT ME, 1993, J BIOL CHEM, V268, P26712
- Saegusa J, 2008, J INVEST DERMATOL, V128, P2403, DOI 10.1038/jid.2008.119
- Baptiste TA, 2007, EXP CELL RES, V313, P652, DOI 10.1016/j.yexcr.2006.11.005
- Nakajima K, 2014, NEOPLASIA, V16, P939, DOI 10.1016/j.neo.2014.09.005
- Hendrix MJC, 2016, PHARMACOL THERAPEUT, V159, P83, DOI 10.1016/j.pharmthera.2016.01.006
- Takenaka Y, 2004, MOL CELL BIOL, V24, P4395, DOI 10.1128/MCB.24.10.4395-4406.2004
- Serizawa N, 2015, LAB INVEST, V95, P1145, DOI 10.1038/labinvest.2015.77
- Fermino ML, 2013, EUR J IMMUNOL, V43, P1806, DOI 10.1002/eji.201343381
- Andre S, 2014, CARBOHYD RES, V389, P25, DOI 10.1016/j.carres.2013.12.024
- Sakurai T, 2011, ONCOLOGY-BASEL, V81, P24, DOI 10.1159/000333256
- Seetharaman J, 1998, J BIOL CHEM, V273, P13047, DOI 10.1074/jbc.273.21.13047
- de Melo FHM, 2007, J HISTOCHEM CYTOCHEM, V55, P1015, DOI 10.1369/jhc.7A7174.2007
- Maniotis AJ, 1999, AM J PATHOL, V155, P739, DOI 10.1016/S0002-9440(10)65173-5
- HSU DK, 1992, J BIOL CHEM, V267, P14167
- Dufraine J, 2008, ONCOGENE, V27, P5132, DOI 10.1038/onc.2008.227
- MEHUL B, 1994, J BIOL CHEM, V269, P18250
- Zhuo Y, 2008, J BIOL CHEM, V283, P22177, DOI 10.1074/jbc.M8000015200
- WISEMAN DM, 1988, BIOCHEM BIOPH RES CO, V157, P793, DOI 10.1016/S0006-291X(88)80319-X
- Derynck R, 2001, NAT GENET, V29, P117, DOI 10.1038/ng1001-117
- Chen PW, 2013, INT REV CEL MOL BIO, V301, P1, DOI 10.1016/B978-0-12-407704-1.00001-4
- Barboni EAM, 2000, GLYCOBIOLOGY, V10, P1201, DOI 10.1093/glycob/10.11.1201
- Nangia-Makker P, 2007, CANCER RES, V67, P11760, DOI 10.1158/0008-5472.CAN-07-3233
- Birdsall B, 2001, BIOCHEMISTRY-US, V40, P4859, DOI 10.1021/bi002907f
- Haudek KC, 2010, BBA-GEN SUBJECTS, V1800, P181, DOI 10.1016/j.bbagen.2009.07.005
- Li X, 2010, CELL DEATH DIFFER, V17, P1277, DOI 10.1038/cdd.2010.8
- Raimond J, 1997, MAMM GENOME, V8, P706, DOI 10.1007/s003359900548
- Berbis MA, 2014, BIOCHEM BIOPH RES CO, V443, P126, DOI 10.1016/j.bbrc.2013.11.063
- Pinho SS, 2015, NAT REV CANCER, V15, P540, DOI 10.1038/nrc3982
- Ochieng J, 1998, BBA-GEN SUBJECTS, V1379, P97, DOI 10.1016/S0304-4165(97)00086-X
- Ideo H, 2011, J BIOL CHEM, V286, P11346, DOI 10.1074/jbc.M110.195925
- Dragomir ACD, 2012, J IMMUNOL, V189, P5934, DOI 10.4049/jimmunol.1201851
- John CM, 2003, CLIN CANCER RES, V9, P2374
- Borges BE, 2013, CHEM-BIOL INTERACT, V206, P37, DOI 10.1016/j.cbi.2013.08.005
- Wang YG, 2012, EXP MOL MED, V44, P387, DOI 10.3858/emm.2012.44.6.044
- AGRWAL N, 1993, J BIOL CHEM, V268, P14932
- Wu KL, 2013, J GASTROENTEROL, V48, P350, DOI 10.1007/s00535-012-0663-3
- Mazurek N, 2012, CELL DEATH DIFFER, V19, P523, DOI 10.1038/cdd.2011.123
- Yang RY, 1996, P NATL ACAD SCI USA, V93, P6737, DOI 10.1073/pnas.93.13.6737
- Zeng Y, 2007, J BONE MINER RES, V22, P1851, DOI 10.1359/JBMR.070620
- SATO S, 1993, EXP CELL RES, V207, P8, DOI 10.1006/excr.1993.1157
- Gong HC, 1999, CANCER RES, V59, P6239
- Nakahara S, 2006, CANCER RES, V66, P9995, DOI 10.1158/0008-5472.CAN-06-1772
- OCHIENG J, 1994, BIOCHEMISTRY-US, V33, P14109, DOI 10.1021/bi00251a020
- Jia WZ, 2013, AM J PATHOL, V182, P1821, DOI 10.1016/j.ajpath.2013.01.017
- Balan V, 2012, J BIOL CHEM, V287, P5192, DOI 10.1074/jbc.C111.331686
- Liu W, 2012, J INVEST DERMATOL, V132, P2828, DOI 10.1038/jid.2012.211
- Rego MJBD, 2013, MED MOL MORPHOL, V46, P92, DOI 10.1007/s00795-013-0013-4
- Hanahan D, 1996, CELL, V86, P353, DOI 10.1016/S0092-8674(00)80108-7
- Markowska AI, 2011, J BIOL CHEM, V286, P29913, DOI 10.1074/jbc.M111.226423
- Dennis JW, 1999, BBA-GEN SUBJECTS, V1473, P21, DOI 10.1016/S0304-4165(99)00167-1
- Mehul B, 1997, J CELL SCI, V110, P1169
- D'Haene N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067029
- de Oliveira JT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134458
- Etulain J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096402
- Halimi H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111836
- Harazono Y, 2014, ONCOTARGET, V5, P9992
- Hernandez J. D., 2002, GLYCOBIOLOGY, V12, P127
- Ikemori RY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111592
- Kim S-Y, 2011, EVID-BASED COMPL ALT, V2011, P1
- Kumar S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059761
- Lakshminarayan Ramya, 2014, Nat Cell Biol, V16, P595, DOI 10.1038/ncb2970
- Leffler Hakon, 2004, Glycoconjugate Journal, V19, P433
- Martins Luciane, 2006, Arq Bras Endocrinol Metabol, V50, P1075, DOI 10.1590/S0004-27302006000600014
- Meany Danni L, 2011, Clin Proteomics, V8, P7, DOI 10.1186/1559-0275-8-7
- Melo FHM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029313
- Meng FR, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126056
- Mirandola L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021811
- Mirandola L, 2014, INT REV IMMUNOL, V33, P417, DOI 10.3109/08830185.2014.911855
- Ruebel KH, 2005, CANCER RES, V65, P1136, DOI 10.1158/0008-5472.CAN-04-3578
- Shalom-Feuerstein R, 2008, CANCER RES, V68, P6608, DOI 10.1158/0008-5472.CAN-08-1117
- Shalom-Feuerstein R, 2005, CANCER RES, V65, P7292, DOI 10.1158/0008-5472.CAN-05-0775
- Sharon N, 2004, GLYCOBIOLOGY, V14, p53R, DOI 10.1093/glycob/cwh122
- Shetty P, 2016, MOL CELL BIOCHEM, V411, P221, DOI 10.1007/s11010-015-2584-y
- Song SM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042699
- Yang Ri-Yao, 2008, Expert Reviews in Molecular Medicine, V10, P1, DOI 10.1017/S1462399408000719