Do colorectal cancer resections improve diabetes in long-term survivors? A case-control study

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art_FAINTUCH_Do_colorectal_cancer_resections_improve_diabetes_in_longterm_2014.PDF (308.23 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
FAINTUCH, Salomao
Citação
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, v.28, n.3, p.1019-1026, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
A clinical study was designed that aimed to analyze whether resection of the large bowel in cancer patients might benefit diabetes mellitus. This prospective case-control study included retrospective information. Patients (n = 247) included diabetic and euglycemic groups with colorectal cancer operations (n = 60), cancer gastrectomy (n = 72), exclusive chemoradiotherapy for rectal cancer (n = 46), and noncancer clinical controls (n = 69). Follow-up periods were, respectively, 79.2 +/- A 27.4, 86.8 +/- A 25.1, 70.0 +/- A 26.3, and 85.1 +/- A 18.2 months (NS). Diabetes groups included patients with prediabetes. Diabetes remission, defined as conversion from diabetes to prediabetes or from this condition to normal, was documented in, respectively, 32.4 % (11 of 34), 41.2 % (14 of 34), 7.1 % (1 of 14), and 7.7 % (3 of 39) in the four cohorts (P = 0.004). Within the same period, progression of euglycemic participants to diabetes occurred in 30.8 % (8 of 26), 63.2 % (24 of 38), 25.0 (8 of 32), and 20.0 % (6 of 30) (P = 0.028). Diabetes amelioration was associated with weight loss in gastrectomy patients but not in the other groups. Dietary intake, estimated in the two surgical populations, did not predict outcome. Diabetes amelioration after colorectal interventions was demonstrated, but progression of euglycemic patients toward prediabetes was not changed in comparison with nonsurgical controls. It is speculated that reshaping of the bowel microbiome or hormone changes after colorectal interventions underlay the improvement in diabetes. Body weight fluctuations could not be incriminated in this investigation.
Palavras-chave
Beta cell function, Body mass index, Colorectal cancer, Colorectal resection, Diabetes mellitus, Dietary intake, Glucose homeostasis, Gut microbiome, New-onset diabetes
URI
https://observatorio.fm.usp.br/handle/OPI/14240
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/35
Artigos e Materiais de Revistas Científicas - ODS/03