Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study

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art_GOMES_Features_of_847_ChildhoodOnset_Systemic_Lupus_Erythematosus_Patients_2016.PDF (117.06 KB)
Citações na Scopus
51
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article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
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Editora
WILEY-BLACKWELL
Autores
TERRERI, Maria T.
MAGALHAES, Claudia S.
SACCHETTI, Silvana B.
MARINI, Roberto
FRAGA, Melissa
Citação
ARTHRITIS CARE & RESEARCH, v.68, n.11, p.1736-1741, 2016
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
ObjectiveTo evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (6 to <12 years); and group C, adolescent (12 to <18 years). MethodsThis was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients. ResultsPatients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Of 39 childhood-onset SLE patients in group A, 3 (8%) were ages <2 years, 4 (10%) were 2 to <3 years, and 32 (82%) were 3 and <6 years. A total of 74 childhood-onset SLE patients were analyzed for C1q levels, and complete C1q deficiency was observed in 3 of 74 patients (4%), all in group A. Groups were similar regarding high frequencies of female sex, nephritis, neuropsychiatric involvement, Systemic Lupus Erythematosus Disease Activity Index 2000 score 8, autoantibody profile, elevated acute phase proteins, and low complement levels (P>0.05). However, the frequency of fever (78% versus 61% versus 47%; P<0.0001), hepatomegaly (42% versus 29% versus 14%; P<0.0001), splenomegaly (28% versus 12% versus 4%; P<0.0001), and discoid lupus (13% versus 4% versus 4%; P=0.020) was significantly higher in group A compared to groups B and C. The frequency of weight loss >2 kg (19% versus 28% versus 36%; P=0.017), photosensitivity (34% versus 41% versus 51%; P=0.006), leukopenia <4,000/mm(3) (14% versus 25% versus 30%; P=0.048), and lymphopenia <1,500/mm(3) (22% versus 41% versus 47%; P=0.011) was significantly lower in group A. ConclusionOur large multicenter study identified the finding that the initial appearance of childhood-onset SLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups.
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https://observatorio.fm.usp.br/handle/OPI/17809
Referências
  1. Abdwani R, 2008, LUPUS, V17, P683, DOI 10.1177/0961203307087611
  2. Akcan-Arikan A, 2007, KIDNEY INT, V71, P1028, DOI 10.1038/sj.ki.5002231
  3. Avcin T, 2009, LUPUS, V18, P894, DOI 10.1177/0961203309106917
  4. Bader-Meunier B, 2005, J PEDIATR-US, V146, P648, DOI 10.1016/j.peds.12.045
  5. Benseler SM, 2005, PEDIATR CLIN N AM, V52, P443, DOI 10.1016/j.pcl.2005.01.010
  6. BRANDT JT, 1995, THROMB HAEMOSTASIS, V74, P1185
  7. Chan James C M, 2002, Pediatr Rev, V23, P47, DOI 10.1542/pir.23-2-47
  8. Chiang LL, 2012, PEDIATR RHEUMATOL, V10, DOI 10.1186/1546-0096-10-12
  9. Chiewchengchol D, 2014, RHEUMATOLOGY, V53, P1504, DOI 10.1093/rheumatology/keu137
  10. Descloux E, 2009, RHEUMATOLOGY, V48, P779, DOI 10.1093/rheumatology/kep067
  11. Gladman DD, 2002, J RHEUMATOL, V29, P288
  12. Hedrich CM, 2011, CLIN RHEUMATOL, V30, P275, DOI 10.1007/s10067-010-1576-2
  13. Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928
  14. Hui-Yuen JS, 2011, LUPUS, V20, P952, DOI 10.1177/0961203311403022
  15. Jesus AA, 2011, LUPUS, V20, P1275, DOI 10.1177/0961203311411598
  16. Levy DM, 2012, PEDIATR CLIN N AM, V59, P345, DOI 10.1016/j.pcl.2012.03.007
  17. Liang MH, 1999, ARTHRITIS RHEUM-US, V42, P599
  18. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents, 2004, PEDIATRICS, V114, P555, DOI 10.1542/PEDS.114.2.S2.555
  19. National KF, 2002, AM J KIDNEY DIS S, V39, pS1, DOI 10.1053/AJKD.2002.30582.PUBMED:11904577
  20. Pluchinotta FR, 2007, LUPUS, V16, P550, DOI 10.1177/0961203307080636
  21. Silva CA, 2012, ARTHRIT CARE RES, V64, P1787, DOI 10.1002/acr.21757
  22. Zhu J, 2013, RHEUMATOL INT, V33, P111, DOI 10.1007/s00296-011-2354-4
  23. Zulian F, 2008, LUPUS, V17, P780, DOI 10.1177/0961203308090992

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - LIM/36