Investigation of human parvovirus B19 occurrence and genetic variability in different leukaemia entities

Imagem de Miniatura
Arquivos
art_BENDIT_Investigation_of_human_parvovirus_B19_occurrence_and_genetic_2013.PDF (430.06 KB)
Citações na Scopus
21
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
COSTA, A. C. da
Citação
CLINICAL MICROBIOLOGY AND INFECTION, v.19, n.1, p.E31-E43, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Human parvovirus B19V (B19V) has been associated with various haematological disorders, but data on its prevalence in leukaemia are scarce. In this cross-sectional study, we investigated patients in Sao Paulo, Brazil with leukaemia to determine the molecular frequency of B19 variants and characterize the viral genetic variability by partial and complete sequencing of the coding of non-structural protein 1 (NS1)/viral capsid proteins 1 and 2 (VP1/VP2). The presence of B19V infections was investigated by PCR amplification of the viral NS1 gene fragment and confirmed by sequencing analysis. The NS1/VP1/VP2 and partially larger gene fragments of the NS1-positive samples were determined by overlapping nested PCR and direct sequencing results. The B19V NS1 was detected in 40 (16%) of 249 bone marrow samples including 12/78 (15.4%) acute lymphoblastic leukaemia, 25/155 (16.1%) acute myeloid leukaemia and 3/16 (18.7%) chronic myeloid leukaemia samples. Of the 40 participants, 25 (62.5%) were infected with genotype 1a and 15 (37.5%) with genotype 3b. The phylogenetic analysis of other regions revealed that 12/40 (30%) of the patients with leukaemia were co-infected with genotypes 1a and 3b. In addition, a new B19V intergenotypic recombinant (1a/3b) and an NS1 non-recombinant genotype 1a were detected in one patient. Our findings demonstrated a relatively high prevalence of B19V monoinfections and dual infections and provide, for the first time, evidence of inter-genotypic recombination in adults with leukaemia that may contribute to the genetic diversity of B19V and may also be a source of new emerging viral strains with future implications for diagnosis, therapy and efficient vaccine development.
Palavras-chave
Coinfection, genotypes, human parvovirus B19, leukaemia, prevalence
URI
https://observatorio.fm.usp.br/handle/OPI/1797
Referências
  1. AGBANDJE M, 1994, VIROLOGY, V203, P106, DOI 10.1006/viro.1994.1460
  2. Candotti D, 2006, J INFECT DIS, V194, P608, DOI 10.1086/506450
  3. Candotti D, 2004, J VIROL, V78, P12169, DOI 10.1128/JVI.78.22.12169-12178.2004
  4. Cassinotti P, 1997, J MED VIROL, V53, P229, DOI 10.1002/(SICI)1096-9071(199711)53:3<229::AID-JMV8>3.3.CO;2-9
  5. Corcioli F, 2008, J MED VIROL, V80, P2005, DOI 10.1002/jmv.21289
  6. DERENZO A, 1994, HAEMATOLOGICA, V79, P259
  7. Elbaz O, 2001, HEMATOLOGY, V5, P383
  8. El-Mahallawy HA, 2004, J PEDIAT HEMATOL ONC, V26, P403, DOI 10.1097/00043426-200407000-00001
  9. Freitas RB, 2008, J CLIN VIROL, V43, P60, DOI 10.1016/j.jcv.2008.03.033
  10. Gallinella G, 2003, J CLIN VIROL, V28, P1, DOI 10.1016/S1386-6532(03)00120-3
  11. Garcia SD, 2011, J CLIN MICROBIOL, V49, P1578, DOI 10.1128/JCM.00077-11
  12. Gustafsson I, 2010, CLIN INFECT DIS, V50, P1426, DOI 10.1086/652286
  13. Hall T. A., 1999, NUCL ACIDS S SER, V41, P95, DOI 10.1111/J.1469-8137.2009.02874.X
  14. Heegaard ED, 1999, PEDIATR HEMAT ONCOL, V16, P329, DOI 10.1080/088800199277155
  15. Hokynar K, 2002, VIROLOGY, V302, P224, DOI 10.1006/viro.2002.1673
  16. Huang Y, 2000, BLOOD CELL MOL DIS, V26, P598, DOI 10.1006/bcmd.2000.0339
  17. Jitschin R, 2011, CLIN MICROBIOL INFEC, V17, P1336, DOI 10.1111/j.1469-0691.2010.03355.x
  18. Johansen JN, 1998, VIRUS RES, V53, P215, DOI 10.1016/S0168-1702(97)00151-2
  19. Keller LW, 2009, ARCH VIROL, V154, P1685, DOI 10.1007/s00705-009-0482-x
  20. Kerr JR, 2003, J CLIN PATHOL, V56, P873, DOI 10.1136/jcp.56.11.873
  21. Kishore J, 2011, INDIAN J MED RES, V133, P407
  22. Lindblom A, 2008, CLIN INFECT DIS, V46, P528, DOI 10.1086/526522
  23. Lole KS, 1999, J VIROL, V73, P152
  24. MORTIMER PP, 1983, NATURE, V302, P426, DOI 10.1038/302426a0
  25. Nakai H, 2000, J VIROL, V74, P9451, DOI 10.1128/JVI.74.20.9451-9463.2000
  26. Nguyen QT, 2002, VIROLOGY, V301, P374, DOI 10.1006/viro.2002.1585
  27. Norja P, 2008, J VIROL, V82, P6427, DOI 10.1128/JVI.00471-08
  28. Norja P, 2006, P NATL ACAD SCI USA, V103, P7450, DOI 10.1073/pnas.0602259103
  29. Parsyan A, 2007, J GEN VIROL, V88, P428, DOI 10.1099/vir.0.82496-0
  30. Rinckel LA, 2009, TRANSFUSION, V49, P1488, DOI 10.1111/j.1537-2995.2009.02160.x
  31. ROBERTSON DL, 1995, J MOL EVOL, V40, P249, DOI 10.1007/BF00163230
  32. SALMINEN MO, 1995, AIDS RES HUM RETROV, V11, P1423, DOI 10.1089/aid.1995.11.1423
  33. Sanabani S, 2006, J CLIN MICROBIOL, V44, P604, DOI 10.1128/JCM.44.2.604-606.2006
  34. Savasan S, 2003, BRIT J HAEMATOL, V120, P168, DOI 10.1046/j.1365-2141.2003.03983_3.x
  35. Schneider B, 2008, J GEN VIROL, V89, P164, DOI 10.1099/vir.0.83053-0
  36. Serpa Mariana, 2010, BMC Blood Disord, V10, P7, DOI 10.1186/1471-2326-10-7
  37. Servant A, 2002, J VIROL, V76, P9124, DOI 10.1128/JVI.76.18.9124-9134.2002
  38. Shackelton LA, 2006, J VIROL, V80, P3666, DOI 10.1128/JVI.80.7.3666-3669.2006
  39. SHAW PJ, 1993, CANCER, V72, P945, DOI 10.1002/1097-0142(19930801)72:3<945::AID-CNCR2820720346>3.0.CO;2-H
  40. Sitar G, 1999, HAEMATOLOGICA, V84, P957
  41. Soderlund M, 1997, LANCET, V349, P1063, DOI 10.1016/S0140-6736(96)09110-6
  42. Soliman OE, 2009, J PEDIAT HEMATOL ONC, V31, P173, DOI 10.1097/MPH.0b013e3181983b2d
  43. Sugiyama H, 1996, LEUKEMIA LYMPHOMA, V21, P49, DOI 10.3109/10428199609067579
  44. Thompson JD, 1997, NUCLEIC ACIDS RES, V25, P4876, DOI 10.1093/nar/25.24.4876
  45. Toan NL, 2006, J GEN VIROL, V87, P2941, DOI 10.1099/vir.0.82037-0
  46. Vasconcelos GM, 2011, EPIGENETICS-US, V6, P1436, DOI 10.4161/epi.6.12.18464
  47. Waldman M, 2007, NAT CLIN PRACT NEPHR, V3, P540, DOI 10.1038/ncpneph0609
  48. Watzinger F, 2004, J CLIN MICROBIOL, V42, P5189, DOI 10.1128/JCM.42.11.5189-5198.2004
  49. Yalcin A, 2009, INT J LAB HEMATOL, V31, P407, DOI 10.1111/j.1751-553X.2008.01052.x
  50. YOTO Y, 1993, ACTA HAEMATOL-BASEL, V90, P8
  51. Young NS, 2004, NEW ENGL J MED, V350, P586, DOI 10.1056/NEJMra030840
  52. Zaki MES, 2010, INT J LAB HEMATOL, V32, P159, DOI 10.1111/j.1751-553X.2009.01150.x
  53. Zhi N, 2006, J VIROL, V80, P5941, DOI 10.1128/JVI.02430-05

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - LIM/52
Carregar mais