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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | ESPIRITO-SANTO, Maria Cristina Carvalho do | - |
dc.contributor.author | PINTO, Pedro Luiz Silva | - |
dc.contributor.author | MOTA, Dan Jesse Goncalves da | - |
dc.contributor.author | GRYSCHEK, Ronaldo Cesar Borges | - |
dc.date.accessioned | 2013-09-23T16:39:41Z | - |
dc.date.available | 2013-09-23T16:39:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.55, n.2, p.129-132, 2013 | - |
dc.identifier.issn | 0036-4665 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1965 | - |
dc.description.abstract | Introduction: Angiostrongylus cantonensis is a natural parasite found in lung arteries of rats, which in humans may cause eosinophilic meningitis. Objective: To report the first case of eosinophilic meningitis caused by Angiostrongylus cantonensis in the city of Sao Paulo, Brazil. Case report: A male patient, 11 years old, living in the southern area of Sao Paulo, was admitted to the Pediatric Emergency Department with ongoing headaches for three days, but no fever or any other complaint. The presence of snails and rodents was reported in the peridomicile. The child was awake, lucid, oriented; muscular strength preserved, isochoric, photo reagent pupils and terminal nuchal rigidity - Glasgow Coma Scale (GCS) = 15. The laboratory tests showed a mild leukocytosis with 1736 eosinophils/mm(3) and the CSF analysis disclosed 160 leukocytes/mm(3) with 36% of eosinophils. The bacterial culture was negative. Computed Cerebral Tomography showed no alterations. The RT-PCR assay for detecting Angiostrongylus cantonensis larvae and DNA was negative. ELISA antibodies for IgG anti-A. cantonensis was negative in serum and undetermined in CSF and samples collected five days after the onset of symptoms. Seroconversion was observed in the sample collected 135 days later. Conclusion: the epidemiological and clinical data, the CSF alterations with eosinophilia and the seroconversion strongly suggest Angiostrongylus cantonensis eosinophilic meningitis. | - |
dc.description.abstract | Introdução: Angiostrongylus cantonensis é um parasito natural das artérias de pulmões de ratos, que pode causar, em humanos, meningite eosinofílica. Objetivo: Relatar o primeiro caso de meningite eosinofílica causado por A. cantonensis na cidade de São Paulo, Brasil. Relato de caso: Paciente do sexo masculino, 11 anos, residente na zona sul de São Paulo, foi admitido no serviço de emergência pediátrica com história de cefaléia há três dias, sem febre ou outras queixas. Relato de presença de moluscos e roedores no peridomicílio. Ao exame físico, criança desperta acianótica, anictérica, hidratada; lúcido, orientado; força muscular preservada, isocórica, pupilas fotorreagentes e rigidez de nuca terminal - Glasgow Coma Scale = 15. Exames laboratoriais indicaram leve leucocitose com 1736 eosinófilos/mm3 e a análise do líquor revelou a presença de 160 leucócitos/mm3 com 36% de eosinófilos. Cultura para bactérias negativa. Tomografia cerebral sem alterações. Pesquisa direta de larvas e de DNA por PCR-RT para Angiostrongylus cantonensis foi negativa. ELISA para anticorpos IgG anti-A. cantonensis negativo no soro e indeterminado no líquor nas amostras coletadas após cinco dias do início dos sintomas. Soroconversão observada na amostra coletada após 135 dias. Conclusão: A história epidemiológica, dados clínicos, alterações liquóricas com presença de eosinofilia e a soroconversão sugerem fortemente o diagnóstico de meningite eosinofílica por A. cantonensis. | - |
dc.language.iso | eng | - |
dc.publisher | INST MEDICINA TROPICAL SAO PAULO | - |
dc.relation.ispartof | Revista do Instituto de Medicina Tropical de Sao Paulo | - |
dc.rights | openAccess | - |
dc.subject | Angiostrongylus cantonensis | - |
dc.subject | Eosinophilic meningitis | - |
dc.subject | CSF eosinophilia | - |
dc.subject.other | meningoencephalitis | - |
dc.subject.other | metastrongylidae | - |
dc.subject.other | infection | - |
dc.subject.other | nematoda | - |
dc.title | THE FIRST CASE OF Angiostrongylus cantonensis EOSINOPHILIC MENINGITIS DIAGNOSED IN THE CITY OF SAO PAULO, BRAZIL | - |
dc.title.alternative | Primeiro caso de meningite eosinofílica diagnosticado na cidade de São Paulo, SP, Brasil | - |
dc.type | article | - |
dc.rights.holder | Copyright INST MEDICINA TROPICAL SAO PAULO | - |
dc.identifier.doi | 10.1590/S0036-46652013000200012 | - |
dc.identifier.pmid | 23563769 | - |
dc.subject.wos | Tropical Medicine | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | PINTO, Pedro Luiz Silva:Adolfo Lutz Inst, Dept Parasitol & Mycol, Sao Paulo, Brazil | - |
hcfmusp.author.external | MOTA, Dan Jesse Goncalves da:Adolfo Lutz Inst, Dept Parasitol & Mycol, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 129 | - |
hcfmusp.description.endpage | 132 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 55 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84875860942 | - |
hcfmusp.origem.id | WOS:000317196000013 | - |
hcfmusp.publisher.city | SAO PAULO | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 32 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/06 |
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