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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | AMARAL, Vinicius C. | - |
dc.contributor.author | MACIEL, Gustavo A. R. | - |
dc.contributor.author | CARVALHO, Katia C. | - |
dc.contributor.author | MARCONDES, Rodrigo R. | - |
dc.contributor.author | SOARES JR., Jose Maria | - |
dc.contributor.author | BARACAT, Edmund C. | - |
dc.date.accessioned | 2013-09-23T16:41:57Z | - |
dc.date.available | 2013-09-23T16:41:57Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | GENERAL AND COMPARATIVE ENDOCRINOLOGY, v.189, p.105-110, 2013 | - |
dc.identifier.issn | 0016-6480 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/2042 | - |
dc.description.abstract | In this work we have evaluated the gene expression profile of prolactin and prolactin receptor in the pituitary and the uterus of female mice with metoclopramide-induced hyperprolactinemia treated with estrogen and/or progesterone. For this purpose, 49 Swiss female mice were allocated to seven groups. Interventions: 50-day treatment with metoclopramide, progesterone and estrogen. Our results showed that in the pituitary, metoclopramide-induced hyperprolactinemia increased prolactin expression. In the castrated animals, progesterone, with or without estrogen, produced an increase in prolactin. Pituitary prolactin receptor and the estrogen and progesterone treatment were responsible for the rise in PRLR-S2. In the uterus, no differences in prolactin expression were found between the different study groups. PRLR-S1 had its expression reduced in all castrated animals as against the castrated group treated with vehicle. In the noncastrated animals, PRLR-52 rose in the metoclopramide-treated group, and, in the castrated animals, its expression diminished in all groups in relation to the vehicle-treated castrated controls. An increase in PRLR-S3 was found in the oophorectomized animals treated with a combination of estrogen and progesterone. PRLR-L rose in the oophorectomized animals treated with progesterone in isolation or in association with estrogen. These findings suggest that metoclopramide associated to progesterone or estrogen may determine an increase in pituitary prolactin and PRLR-S2 expression. The estrogen-progesterone may enhance the expression of PRLR-S3 and PRLR-L isoform of prolactin receptor. | - |
dc.description.sponsorship | FAPESP [2010/51043-3] | - |
dc.language.iso | eng | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.ispartof | General and Comparative Endocrinology | - |
dc.rights | restrictedAccess | - |
dc.subject | Hyperprolactinemia | - |
dc.subject | Prolactin receptor | - |
dc.subject.other | gene-expression | - |
dc.subject.other | estrogen | - |
dc.subject.other | rat | - |
dc.subject.other | progesterone | - |
dc.subject.other | pregnancy | - |
dc.subject.other | biology | - |
dc.subject.other | gland | - |
dc.subject.other | mice | - |
dc.title | Metoclopramide-induced hyperprolactinemia effects on the pituitary and uterine prolactin receptor expression | - |
dc.type | article | - |
dc.rights.holder | Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.identifier.doi | 10.1016/j.ygcen.2013.04.037 | - |
dc.identifier.pmid | 23684968 | - |
dc.subject.wos | Endocrinology & Metabolism | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 105 | - |
hcfmusp.description.endpage | 110 | - |
hcfmusp.description.volume | 189 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84878713756 | - |
hcfmusp.origem.id | WOS:000321231500014 | - |
hcfmusp.publisher.city | SAN DIEGO | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | BARANAO RI, 1991, STEROIDS, V56, P481, DOI 10.1016/0039-128X(91)90006-H | - |
hcfmusp.relation.reference | Bernichtein S, 2010, J ENDOCRINOL, V206, P1, DOI 10.1677/JOE-10-0069 | - |
hcfmusp.relation.reference | Betzold CM, 2004, J MIDWIFERY WOM HEAL, V49, P151, DOI 10.1016/S1526-9523(03)00536-1 | - |
hcfmusp.relation.reference | Binart N, 2010, TRENDS ENDOCRIN MET, V21, P362, DOI 10.1016/j.tem.2010.01.008 | - |
hcfmusp.relation.reference | Bole-Feysot C, 1998, ENDOCR REV, V19, P225, DOI 10.1210/er.19.3.225 | - |
hcfmusp.relation.reference | Brooks CL, 2012, ENDOCR REV, V33, P504, DOI 10.1210/er.2011-1040 | - |
hcfmusp.relation.reference | Casanueva FF, 2006, CLIN ENDOCRINOL, V65, P265, DOI 10.1111/j.1365-2265.2006.02562.x | - |
hcfmusp.relation.reference | Freeman ME, 2000, PHYSIOL REV, V80, P1523 | - |
hcfmusp.relation.reference | Goffin V, 2002, ANNU REV PHYSIOL, V64, P47, DOI 10.1146/annurev.physiol.64.081501.131049 | - |
hcfmusp.relation.reference | Gomes Regina Célia Teixeira, 2009, Rev Bras Ginecol Obstet, V31, P385, DOI 10.1590/S0100-72032009000800003 | - |
hcfmusp.relation.reference | Guivarc'h-Leveque A, 2011, J GYNECOL OBST BIO R, V40, P498, DOI 10.1016/j.jgyn.2011.03.003 | - |
hcfmusp.relation.reference | Iwanaga T, 2011, BIOMED RES-TOKYO, V32, P225 | - |
hcfmusp.relation.reference | Jacobs E, 2011, J NEUROSCI, V31, P5286, DOI 10.1523/JNEUROSCI.6394-10.2011 | - |
hcfmusp.relation.reference | Johren O, 1997, J NEUROSCI, V17, P8283 | - |
hcfmusp.relation.reference | Kansra S., 2010, PLOS ONE, V5, P100 | - |
hcfmusp.relation.reference | Kinoshita H, 2001, GYNECOL OBSTET INVES, V52, P132, DOI 10.1159/000052958 | - |
hcfmusp.relation.reference | Panzan MQ, 2006, HUM REPROD, V21, P2514, DOI 10.1093/humrep/del093 | - |
hcfmusp.relation.reference | Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, P45 | - |
hcfmusp.relation.reference | Piroli GG, 2001, J NEUROENDOCRINOL, V13, P302, DOI 10.1046/j.1365-2826.2001.00633.x | - |
hcfmusp.relation.reference | Radl DB, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018097 | - |
hcfmusp.relation.reference | Rossi A.G.Z., 2009, FERTIL STERIL, V93, P1643 | - |
hcfmusp.relation.reference | Rossi AGZ, 2002, GYNECOL OBSTET INVES, V54, P185, DOI 10.1159/000068380 | - |
hcfmusp.relation.reference | Sluczanowska-Glabowska S, 2010, FOLIA HISTOCHEM CYTO, V48, P447, DOI 10.2478/v10042-010-0074-3 | - |
hcfmusp.relation.reference | Suzuki T, 2008, INVEST OPHTH VIS SCI, V49, P1797, DOI 10.1167/iovs.07-1458 | - |
hcfmusp.relation.reference | Yin P, 2000, NEUROENDOCRINOLOGY, V72, P72, DOI 10.1159/000054574 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
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