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  2. Faculdade de Medicina - FM
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Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2161
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorGIANNOTTI, Karina Cristina-
dc.contributor.authorSESSO, Antonio-
dc.contributor.authorGREGO, Kathleen Fernandes-
dc.contributor.authorFERNANDES, Wilson-
dc.contributor.authorCARDOSO JR., Rubens Pinto-
dc.contributor.authorCAMARGO, Gabriela Grilo-
dc.contributor.authorCARNEIRO, Sylvia Mendes-
dc.date.accessioned2013-09-23T16:44:27Z-
dc.date.available2013-09-23T16:44:27Z-
dc.date.issued2013-
dc.identifier.citationTOXICON, v.70, p.32-43, 2013-
dc.identifier.issn0041-0101-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2161-
dc.description.abstractThe venom of viperid snakes is collected monthly at Butantan Institute for research purposes and production of antivenoms. Here we describe histological and ultrastructural changes on Crotalus durissus terrificus and Bothrops sp. venom glands with defective venom production. Secretory tubules commonly showed partial or total obliteration of their lumina by masses of necrotic cells and cellular debris. Secretory cells showed varying degrees of degenerative and/or metaplastic alterations seriously affecting the structures responsible for the synthesis and secretion of venom. The intertubular connective tissue presented fibroblast hyperplasia, inflammatory cells infiltration, vacuolated cells and blood vessels alterations. In two venom glands out of nineteen snakes examined, virus-like particles were found. The alterations observed in most of the glands could have been caused by excessive manual pressure, during venom extraction routine, causing disruption of the secretory tubules and leakage of venom to the intertubular connective tissue.-
dc.description.sponsorshipFundacao Butantan [106399/2007-1]-
dc.description.sponsorshipCNPq/PIBIC scholarship [110955/2006-4]-
dc.language.isoeng-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.ispartofToxicon-
dc.rightsrestrictedAccess-
dc.subjectViperid snakes-
dc.subjectVenom gland pathology-
dc.subjectVenom production-
dc.subject.otherinclusion-body disease-
dc.subject.othersnake-venom-
dc.subject.otherbothrops-jararaca-
dc.subject.otherboa constrictors-
dc.subject.othersecretory-cells-
dc.subject.othermetalloproteinases-
dc.subject.otherpalaestinae-
dc.subject.otherdamage-
dc.subject.otherprotein-
dc.subject.otherretroviruses-
dc.titleViperid venom glands with defective venom production. Morphological study-
dc.typearticle-
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTD-
dc.identifier.doi10.1016/j.toxicon.2013.03.019-
dc.identifier.pmid23583664-
dc.subject.wosPharmacology & Pharmacy-
dc.subject.wosToxicology-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalGIANNOTTI, Karina Cristina:Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalGREGO, Kathleen Fernandes:Inst Butantan, Lab Herpetol, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalFERNANDES, Wilson:Inst Butantan, Lab Herpetol, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalCARDOSO JR., Rubens Pinto:SUCEN Reg 08, Superintendencia Controle Endemias, BR-15060040 Sao Jose Do Rio Preto, SP, Brazil-
hcfmusp.author.externalCAMARGO, Gabriela Grilo:Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalCARNEIRO, Sylvia Mendes:Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo, Brazil-
hcfmusp.description.beginpage32-
hcfmusp.description.endpage43-
hcfmusp.description.volume70-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000321537200005-
hcfmusp.origem.id2-s2.0-84877047559-
hcfmusp.publisher.cityOXFORD-
hcfmusp.publisher.countryENGLAND-
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dc.description.indexMEDLINE-
hcfmusp.remissive.sponsorshipButantan-
hcfmusp.remissive.sponsorshipCNPq-
hcfmusp.citation.scopus6-
hcfmusp.scopus.lastupdate2024-04-12-
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Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - LIM/06
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses


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