Effect of neoadjuvant chemotherapy on women undergoing breast cancer surgery and immediate breast reconstruction with latissimus dorsi flap and silicone implants

Imagem de Miniatura
Arquivos
art_D'ALESSANDRO_Effect_of_neoadjuvant_chemotherapy_on_women_undergoing_breast_2017.PDF (954.13 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
D'ALESSANDRO, Gabriel Salum
POVEDANO, Alejandro
SANTOS, Lauren Klas Kurk Leme dos
GOES, Joao Carlos de Sampaio
Citação
EUROPEAN JOURNAL OF PLASTIC SURGERY, v.40, n.4, p.299-308, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The use of the latissimus dorsi flap in immediate breast reconstruction is a relatively simple procedure using a flap with a very reliable and consistent vascularity. Neoadjuvant chemotherapy improves local surgical conditions; however, most chemotherapeutic agents are cytotoxic and may increase the risk of postoperative complications. This study evaluated the effects of neoadjuvant chemotherapy on women with cancer who underwent immediate breast reconstruction with latissimus dorsi flap and silicone implants. Data were collected from medical records of 102 patients with cancer who had undergone immediate breast reconstruction with latissimus dorsi flap and silicone implants from August 2010 to December 2014. Thirty-three patients received neoadjuvant chemotherapy (study group) and 69 patients underwent primary surgical treatment (control group). Three (2.9%) patients in the study group had a major postoperative complication (two cases of hematoma requiring surgical drainage and a case of flap necrosis), which was the only variable showing a significant difference between groups (P = 0.032). Neoadjuvant chemotherapy followed by cancer surgery with immediate breast reconstruction with latissimus dorsi flap and silicone implants was not associated with an increased risk of postoperative surgical and clinical minor complications. It was associated with a significant increase in postoperative major complications, despite the small number of cases. However, patients who received neoadjuvant chemotherapy had a significantly more aggressive disease and advanced-stage cancer, and required a more extensive cancer surgery.
Palavras-chave
Neoadjuvant therapy, Drug therapy, Mammaplasty, Myocutaneous flap
URI
https://observatorio.fm.usp.br/handle/OPI/21768
Referências
  1. Abt NB, 2014, JAMA SURG, V149, P1068, DOI 10.1001/jamasurg.2014.1076
  2. Al-Ghazal SK, 2000, EUR J SURG ONCOL, V26, P17, DOI 10.1053/ejso.1999.0733
  3. Azzawi K, 2010, PLAST RECONSTR SURG, V126, P1, DOI 10.1097/PRS.0b013e3181da8699
  4. BOSTWICK J, 1978, PLAST RECONSTR SURG, V61, P682, DOI 10.1097/00006534-197805000-00004
  5. Brasil. Ministerio da Saude, INC CANC BRAS
  6. FISHER B, 1985, NEW ENGL J MED, V312, P665, DOI 10.1056/NEJM198503143121101
  7. GARGAN TJ, 1985, PLAST RECONSTR SURG, V75, P430, DOI 10.1097/00006534-198503000-00027
  8. Gill PS, 2004, PLAST RECONSTR SURG, V113, P1153, DOI 10.1097/01.PRS.0000110328.47206.50
  9. Gouy S, 2005, ANN SURG ONCOL, V12, P161, DOI 10.1245/ASO.2005.04.003
  10. Halsted W S, 1894, Ann Surg, V20, P497, DOI 10.1097/00000658-189407000-00075
  11. Hammond DC, 2009, PLAST RECONSTR SURG, V124, P1055, DOI 10.1097/PRS.0b013e3181b6bf05
  12. Langstein HN, 2003, PLAST RECONSTR SURG, V111, P712, DOI 10.1097/01.PRS.0000041441.42563.95
  13. Liu Ying, 2009, Journal of Medical and Dental Sciences, V56, P55
  14. MADDEN JL, 1965, SURG GYNECOL OBSTETR, V121, P1221
  15. Mehrara BJ, 2006, PLAST RECONSTR SURG, V118, P1100, DOI 10.1097/01.prs.0000236898.87398.d6
  16. Mieog JS, 2007, COCHRANE DB SYST REV, V2, DOI 10.1002/14651858.CD005002.PUB2
  17. Mustonen P, 2004, EJSO, V30, P817, DOI 10.1016/j.ejso.2004.06.003
  18. Oh E, 2012, J PLAST RECONSTR AES, V65, pE267, DOI 10.1016/j.bjps.2012.04.053
  19. OLIVARI N, 1976, BRIT J PLAST SURG, V29, P126, DOI 10.1016/0007-1226(76)90036-9
  20. PATEY DH, 1948, BRIT J CANCER, V2, P7, DOI 10.1038/bjc.1948.2
  21. Rastogi P, 2008, J CLIN ONCOL, V26, P778, DOI 10.1200/JCO.2007.15.0235
  22. Schaverien MV, 2013, EJSO-EUR J SURG ONC, V39, P430, DOI 10.1016/j.ejso.2013.02.015
  23. SCHNEIDER WJ, 1977, BRIT J PLAST SURG, V30, P277, DOI 10.1016/0007-1226(77)90117-5
  24. Selber JC, 2006, ANN PLAS SURG, V56, P492, DOI 10.1097/01.sap.0000210180.72721.4a
  25. Tansini I, 1906, GAZETTA MED ITAL, V57, P141
  26. Taylor CW, 2005, BREAST, V14, P118, DOI 10.1016/j.breast.2004.08.006
  27. VERONESI U, 1981, NEW ENGL J MED, V305, P6, DOI 10.1056/NEJM198107023050102

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/04
Artigos e Materiais de Revistas Científicas - ODS/03