Patients with Parkinson disease present high ambulatory blood pressure variability

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art_KANEGUSUKU_Patients_with_Parkinson_disease_present_high_ambulatory_blood_2017.PDF (76.07 KB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
KANEGUSUKU, Helcio
SILVA-BATISTA, Carla
PECANHA, Tiago
SILVA-JUNIOR, Natan
QUEIROZ, Andreia
COSTA, Luiz
MELLO, Marco
UGRINOWITSCH, Carlos
FORJAZ, Claudia
Citação
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, v.37, n.5, p.530-535, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Patients with Parkinson disease (PD) present blunted nocturnal blood pressure fall and similar ambulatory blood pressure variability (ABPV) measured by standard deviation (SD) and coefficient of variation (CV) compared with healthy subjects. However, these classical indices of ABPV have limited validity in individuals with circadian blood pressure alterations. New indices, such as the average of daytime and night-time standard deviation weighted by the duration of the daytime and night-time intervals (SDdn) and the average real variability (ARV), remove the influence of the daytime and the night-time periods on ABPV. This study assessed ABPV by SDdn and ARV in PD. Twenty-one patients with PD (11 men, 66 +/- 2years, stages 2-3 of modified Hoehn & Yahr) and 21 matched controls without Parkinson disease (9 men, 64 +/- 1years old) underwent blood pressure monitoring for 24h. ABPV was analysed by 24h, daytime and night-time SD and CV, and by the SDdn and ARV. Systolic/diastolic 24-h and night-time SD and CV were similar between the patients with PD and the controls. The patients with PD presented higher daytime systolic/diastolic CV and SD than the controls (10<bold></bold>4 +/- 0<bold></bold>9/12<bold></bold>3 +/- 0<bold></bold>8 versus 7<bold></bold>0 +/- 0<bold></bold>3/9<bold></bold>9 +/- 0<bold></bold>5%, P<0<bold></bold>05; 12<bold></bold>6 +/- 1<bold></bold>0/9<bold></bold>1 +/- 0<bold></bold>5 versus 8<bold></bold>6 +/- 0<bold></bold>4/7<bold></bold>5 +/- 0<bold></bold>3mmHg, P<0<bold></bold>05, respectively) as well as higher systolic/diastolic SDdn (10<bold></bold>9 +/- 0<bold></bold>8/8<bold></bold>2 +/- 0<bold></bold>5 versus 8<bold></bold>2 +/- 0<bold></bold>3/7<bold></bold>1 +/- 0<bold></bold>2mmHg, P<0<bold></bold>05, respectively) and ARV (8<bold></bold>8 +/- 0<bold></bold>6/6<bold></bold>9 +/- 0<bold></bold>3 versus 7<bold></bold>2 +/- 0<bold></bold>2/6<bold></bold>0 +/- 0<bold></bold>2mmHg, P<0<bold></bold>05, respectively). In conclusion, patients with PD have higher ABPV than control subjects as assessed by SDd, CVd, SDdn and AVR.
Palavras-chave
ambulatory blood pressure, circadian blood pressure, circadian variability, nocturnal blood pressure fall, Parkinsonism
URI
https://observatorio.fm.usp.br/handle/OPI/21886
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MFT
Artigos e Materiais de Revistas Científicas - LIM/34