Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation
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Citações na Scopus
44
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Citação
TRANSPLANTATION PROCEEDINGS, v.43, n.5, p.1443-1449, 2011
Resumo
We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.
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Referências
- AMES BN, 1993, P NATL ACAD SCI USA, V90, P7915, DOI 10.1073/pnas.90.17.7915
- TAYLOR JE, 1993, TRANSPLANTATION, V55, P500, DOI 10.1097/00007890-199303000-00009
- Beckman KB, 1997, J BIOL CHEM, V272, P19633, DOI 10.1074/jbc.272.32.19633
- TERASAKI PI, 1995, NEW ENGL J MED, V333, P333, DOI 10.1056/NEJM199508103330601
- Shalansky SJ, 2005, HEART, V91, P997, DOI 10.1136/hrt.2004.053579
- de Araujo M, 2005, J AM SOC NEPHROL, V16, P3339, DOI 10.1681/2004100832
- Perico N, 2004, LANCET, V364, P1814, DOI 10.1016/S0140-6736(04)17406-0
- COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
- Medina-Pestana JO, 2006, TRANSPLANTATION, V81, P1510, DOI 10.1097/01.tp.0000214934.48677.e2
- Tariq M, 1999, NEPHROL DIAL TRANSPL, V14, P923, DOI 10.1093/ndt/14.4.923
- Arumugam TV, 2009, SHOCK, V32, P4, DOI 10.1097/SHK.0b013e318193e333
- Nitescu N, 2006, NEPHROL DIAL TRANSPL, V21, P1240, DOI 10.1093/ndt/gfk032
- DiMari J, 1997, AM J PHYSIOL-RENAL, V272, pF292
- Hasegawa T, 2009, AM J PHYSIOL-HEART C, V296, pH1007, DOI 10.1152/ajpheart.00498.2008
- Santiago FM, 2008, TRANSPL P, V40, P2978, DOI 10.1016/j.transproceed.2008.08.103
- Zafarullah M, 2003, CELL MOL LIFE SCI, V60, P6, DOI 10.1007/s000180300001
- Levey AS, 1999, ANN INTERN MED, V130, P461
- Tepel M, 2003, CIRCULATION, V107, P992, DOI 10.1161/01.CIR.0000050628.11305.30
- Lin A, 2004, TRANSPLANTATION, V78, P654, DOI 10.1097/01.tp.0000131664.18670.17
- Lefaucheur C, 2008, AM J TRANSPLANT, V8, P324, DOI 10.1111/j.1600-6143.2007.02072.x
- Mazzucchi E, 2006, TRANSPLANTATION, V81, P840, DOI 10.1097/01.tp.0000203559.57088.f6
- Drager LF, 2004, NEPHROL DIAL TRANSPL, V19, P1803, DOI 10.1093/ndt/gfh261
- Majano PL, 2004, J HEPATOL, V40, P632, DOI 10.1016/j.jhep.2003.12.009
- Shimizu MHM, 2005, KIDNEY INT, V68, P2208
- Cuzzocrea S, 2000, CARDIOVASC RES, V47, P537, DOI 10.1016/S0008-6363(00)00018-3
- Di Giorno C, 2006, TRANSPLANT P, V38, P2774, DOI 10.1016/j.transproceed.2006.08.178
- Fuentes MCR, 2008, TRANSPL P, V40, P2897, DOI 10.1016/j.transproceed.2008.08.109
- Gotoh M, 1997, NEPHROL DIAL TRANSPL, V12, P713, DOI 10.1093/ndt/12.4.713
- Leite PF, 2003, ARTERIOSCL THROM VAS, V23, P2197, DOI 10.1161/01.ATV.0000093980.46838.41
- Shimizu MHM, 2008, NEPHROL DIAL TRANSPL, V23, P3067, DOI 10.1093/ndt/gfn237