Immunomodulatory effects of crotoxin isolated from Crotalus durissus terrificus venom in mice immunised with human serum albumin

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art_FAVORETTO_Immunomodulatory_effects_of_crotoxin_isolated_from_Crotalus_durissus_2011.PDF (529.92 KB)
Citações na Scopus
23
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
FAVORETTO, B. C.
RICARDI, R.
SILVA, S. R.
FERNANDES, I.
TAKEHARA, H. A.
FAQUIM-MAURO, E. L.
Citação
TOXICON, v.57, n.4, p.600-607, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Crotalus durissus terrificus venom and its main component, crotoxin (CTX), have the ability to down-modulate the immune system. Certain mechanisms mediated by cells and soluble factors of the immune system are responsible for the elimination of pathogenic molecules to ensure the specific protection against subsequent antigen contact. Accordingly, we evaluated the immunomodulatory effects of CTX on the immune response of mice that had been previously primed by immunisation with human serum albumin (HSA). CTX inoculation after HSA immunisation, along with complete Freund's adjuvant (CFA) or Aluminium hydroxide (Alum) immunisation, was able to suppress anti-HSA IgG1 and IgG2a antibody production. We showed that the inhibitory effects of this toxin are not mediated by necrosis or apoptosis of any lymphoid cell population. Lower proliferation of T lymphocytes from mice immunised with HSA/CFA or HSA/Alum that received the toxin was observed in comparison to the mice that were only immunised. In conclusion, CTX is able to exert potent inhibitory effects on humoural and cellular responses induced by HSA immunisation, even when injected after an innate immune response has been initiated.
Palavras-chave
Snake venom, Crotoxin, Antibody production, T cell proliferative response, Immunomodulation
URI
https://observatorio.fm.usp.br/handle/OPI/24138
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/62