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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SANT'ANA, A. J. | - |
dc.contributor.author | OTSUKI, D. A. | - |
dc.contributor.author | NOEL-MORGAN, J. | - |
dc.contributor.author | LEITE, V. F. | - |
dc.contributor.author | FANTONI, D. T. | - |
dc.contributor.author | HAJJAR, L. Abrahao | - |
dc.contributor.author | GALAS, F. R. Barbosa Gomes | - |
dc.contributor.author | ALMEIDA, J. Pinheiro De | - |
dc.contributor.author | FUKUSHIMA, J. | - |
dc.contributor.author | AULER JR., J. O. Costa | - |
dc.date.accessioned | 2013-07-30T14:35:05Z | - |
dc.date.available | 2013-07-30T14:35:05Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | MINERVA ANESTESIOLOGICA, v.78, n.4, p.426-433, 2012 | - |
dc.identifier.issn | 0375-9393 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/272 | - |
dc.description.abstract | Background. Acute normovolemic hemodilution (ANH) is an alternative to blood transfusion in surgeries involving blood loss. This experimental study was designed to evaluate whether pulse pressure variation (PPV) would be an adequate tool for monitoring changes in preload during ANH, as assessed by transesophageal echocardiography. Methods. Twenty-one anesthetized and mechanically ventilated pigs were randomized into three groups: CTL (control), HES (hemodilution with 6% hydroxyethyl starch at a 1:1 ratio) or NS (hemodilution with saline 0.9% at a 3:1 ratio). Hemodilution was performed in animals of groups NS and HES in two stages, with target hematocrits 22% and 15%, achieved at 30-minute intervals. After two hours, 50% of the blood volume withdrawn was transfused and animals were monitored for another hour. Statistical analysis was based on ANOVA for repeated measures followed by multiple comparison test (P<0.05). Pearson's correlations were performed between changes in left ventricular end-diastolic volume (LVEDV) and PPV, central venous pressure (CVP) and pulmonary artery occlusion pressure (PAOP). Results. Group NS received a significantly greater amount of fluids during ANH (NS, 900 +/- 168 mL vs. HES, 200 +/- 50 mL, P<0.05) and presented greater urine output (NS, 2643 +/- 1097mL vs. HES, 641 +/- 338mL, P<0.001). Significant decreases in LVEDV were observed in group NS from completion of ANH until transfusion. In group HES, only increases in LVEDV were observed, at the end of ANH and at transfusion. Such changes in LVEDV (Delta LVEDV) were better reflected by changes in PPV (Delta PPV, R=-0.62) than changes in CVP (Delta CVP R=0.32) or in PAOP (Delta PAOP, R=0.42, respectively). Conclusion. Changes in preload during ANH were detected by changes in PPV. Delta PPV was superior to Delta PAOP and Delta CVP to this end. (Minerva Anestesiol 2012;78:426-33) | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [06/55221-8] | - |
dc.language.iso | eng | - |
dc.publisher | EDIZIONI MINERVA MEDICA | - |
dc.relation.ispartof | Minerva Anestesiologica | - |
dc.rights | restrictedAccess | - |
dc.subject | Pressure | - |
dc.subject | Hemodilution | - |
dc.subject | Saline solution, hyperronic | - |
dc.subject.other | randomized controlled-trial | - |
dc.subject.other | stroke volume variation | - |
dc.subject.other | fluid-responsiveness | - |
dc.subject.other | hemorrhagic-shock | - |
dc.subject.other | cardiac-surgery | - |
dc.subject.other | transfusion | - |
dc.subject.other | ventilation | - |
dc.subject.other | trauma | - |
dc.subject.other | output | - |
dc.subject.other | index | - |
dc.title | Use of pulse pressure variation to estimate changes in preload during experimental acute normovolemic hemodilution | - |
dc.type | article | - |
dc.rights.holder | Copyright EDIZIONI MINERVA MEDICA | - |
dc.identifier.pmid | 22240618 | - |
dc.subject.wos | Anesthesiology | - |
dc.subject.wos | Critical Care Medicine | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SANT'ANA, A. J.:Univ Sao Paulo, Fac Med, Postgrad Anesthesiol Program, BR-05403000 Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 426 | - |
hcfmusp.description.endpage | 433 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 78 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000303791900008 | - |
hcfmusp.origem.id | 2-s2.0-84859382447 | - |
hcfmusp.publisher.city | TURIN | - |
hcfmusp.publisher.country | ITALY | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 8 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/08 |
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