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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | PIMENTEL-QUIROZ, Victor R. | |
dc.contributor.author | UGARTE-GIL, Manuel E. | |
dc.contributor.author | PONS-ESTEL, Guillermo J. | |
dc.contributor.author | SORIANO, Enrique R. | |
dc.contributor.author | SAURIT, Veronica | |
dc.contributor.author | SATO, Emilia I. | |
dc.contributor.author | COSTALLAT, Lilian T. Lavras | |
dc.contributor.author | MOLINA, Jose Fernando | |
dc.contributor.author | IGLESIAS-GAMARRA, Antonio | |
dc.contributor.author | REYES-LLERENA, Gil | |
dc.contributor.author | NEIRA, Oscar J. | |
dc.contributor.author | BARILE, Leonor A. | |
dc.contributor.author | SILVEIRA, Luis H. | |
dc.contributor.author | SEGAMI, Maria Ines | |
dc.contributor.author | CHACON-DIAZ, Rosa | |
dc.contributor.author | WOJDYLA, Daniel | |
dc.contributor.author | ALARCON, Graciela S. | |
dc.contributor.author | PONS-ESTEL, Bernardo A. | |
dc.contributor.author | BONFA, Eloisa | |
dc.contributor.author | BORBA, Eduardo Ferreira | |
dc.date.accessioned | 2018-11-21T17:00:07Z | |
dc.date.available | 2018-11-21T17:00:07Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | SEMINARS IN ARTHRITIS AND RHEUMATISM, v.47, n.2, p.199-203, 2017 | |
dc.identifier.issn | 0049-0172 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/29369 | |
dc.description.abstract | Aims: To determine the factors predictive of disease activity early in the course of SLE (baseline visit). Methods: Patients from GLADEL, a multi-national, multi-ethnic, Latin-American lupus cohort were included. Disease activity was evaluated at baseline with the SLEDAI score. Demographic characteristics (age at diagnosis, gender, ethnicity, marital status, educational level, medical coverage and socioeconomic status) were assessed. Disease duration was defined as the time between the fourth ACR criterion and baseline. Time to criteria accrual was defined as the interval between the first and fourth ACR criterion. Use of glucocorticoids was recorded as the highest dose received before the baseline visit. Antimalarials and immunosuppressive drugs were recorded as use or not use. Univariable and multivariable analysis were performed. Model selection was based on backward elimination. Results: One thousand two hundred sixty-eight patients were included; 1136 (89.6%) of them were female. Mean age at diagnosis was 29.2 (SD: 12.3) years. Five hundred sixty-five (44.6%) were Mestizo, 539 (42.5%) were Caucasians and 164 (12.9%) were African-Latin-Americans. The mean SLEDAI at baseline was 10.9 (SD: 8.4). Longer time between first and fourth ACR criterion, medical coverage, a dose of prednisone between 15 and 60 mg/d, and the use of antimalarials were factors protective of disease activity, while Mestizo and African-Latin-American ethnicities were predictive factors. Conclusions: Mestizo and African-Latin-American ethnicities were predictive whereas antimalarial use, medical coverage, and longer time to criteria accrual were protective of higher disease activity early in the disease course. | |
dc.language.iso | eng | |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | |
dc.relation.ispartof | Seminars in Arthritis and Rheumatism | |
dc.rights | restrictedAccess | |
dc.subject | Systemic lupus erythematosus | |
dc.subject | Disease activity | |
dc.subject | Antimalarial use | |
dc.subject | Ethnic group | |
dc.subject.other | systemic-lupus-erythematosus | |
dc.subject.other | 3 ethnic-groups | |
dc.subject.other | inception cohort | |
dc.subject.other | single-center | |
dc.subject.other | damage | |
dc.subject.other | nephritis | |
dc.subject.other | hydroxychloroquine | |
dc.subject.other | association | |
dc.subject.other | mortality | |
dc.subject.other | survival | |
dc.title | Factors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohort | |
dc.type | article | |
dc.rights.holder | Copyright W B SAUNDERS CO-ELSEVIER INC | |
dc.contributor.groupauthor | Bonfa, Eloisa | |
dc.contributor.groupauthor | Borba, Eduardo Ferreira | |
dc.identifier.doi | 10.1016/j.semarthrit.2017.01.012 | |
dc.identifier.pmid | 28291583 | |
dc.subject.wos | Rheumatology | |
dc.type.category | review | |
dc.type.version | publishedVersion | |
hcfmusp.author.external | PIMENTEL-QUIROZ, Victor R.:EsSalud, Hosp Guillermo Almenara Irigoyen, Dept Rheumatol, Ave Grau 800, Lima 13, Peru | |
hcfmusp.author.external | UGARTE-GIL, Manuel E.:EsSalud, Hosp Guillermo Almenara Irigoyen, Dept Rheumatol, Ave Grau 800, Lima 13, Peru; Univ Cient Sur, Lima, Peru | |
hcfmusp.author.external | PONS-ESTEL, Guillermo J.:Hosp Clin Barcelona, Inst Clin Med & Dermatol, Dept Autoimmune Dis, Barcelona, Spain | |
hcfmusp.author.external | SORIANO, Enrique R.:Hosp Italiano Buenos Aires, Serv Clin Med, Secc Reumatol, Buenos Aires, DF, Argentina; Fdn Dr Pedro M Catoggio Progreso Reumatol, Buenos Aires, DF, Argentina | |
hcfmusp.author.external | SAURIT, Veronica:Hosp Privado, Ctr Med Cordoba, Serv Reumatol, Cordoba, Argentina | |
hcfmusp.author.external | SATO, Emilia I.:Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Disciplina Reumatol, Dept Med, Sao Paulo, Brazil | |
hcfmusp.author.external | COSTALLAT, Lilian T. Lavras:Univ Estadual Campinas UNICAMP, Fac Ciencias Med, Dept Clin Med, Disciplina Reumatol, Campinas, SP, Brazil | |
hcfmusp.author.external | MOLINA, Jose Fernando:Ctr Integral Reumatol, Reumalab, Medellin, Colombia | |
hcfmusp.author.external | IGLESIAS-GAMARRA, Antonio:Univ Bosque, Dept Med, Bogota, Colombia | |
hcfmusp.author.external | REYES-LLERENA, Gil:Ctr Invest Med Quirurg CIMEQ, Serv Reumatol, Havana, Cuba | |
hcfmusp.author.external | NEIRA, Oscar J.:Univ Chile, Fac Med, Hosp Salvador, Serv Reumatol, Santiago, Chile | |
hcfmusp.author.external | BARILE, Leonor A.:Inst Mexicano Seguro Social, Hosp Especialidades Ctr Med Nacl Siglo 19, Serv Reumatol, Ciudad De Mexico, Mexico | |
hcfmusp.author.external | SILVEIRA, Luis H.:Inst Nacl Cardiol Ignacio Chavez, Dept Reumatol, Ciudad De Mexico, Mexico | |
hcfmusp.author.external | SEGAMI, Maria Ines:Essalud, Hosp Nacl Edgardo Rebagliatti Martins, Serv Reumatol, Lima, Peru | |
hcfmusp.author.external | CHACON-DIAZ, Rosa:Hosp Univ Caracas, Ctr Nacl Enfermedades Reumat, Serv Reumatol, Caracas, Venezuela | |
hcfmusp.author.external | WOJDYLA, Daniel:GLADEL, Dept Stat, Rosario, Santa Fe, Argentina | |
hcfmusp.author.external | ALARCON, Graciela S.:Univ Alabama Birmingham, Sch Med, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA | |
hcfmusp.author.external | PONS-ESTEL, Bernardo A.:Hosp Prov Rosario, Serv Reumatol, Rosario, Santa Fe, Argentina | |
hcfmusp.description.beginpage | 199 | |
hcfmusp.description.endpage | 203 | |
hcfmusp.description.issue | 2 | |
hcfmusp.description.volume | 47 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000412382000008 | |
hcfmusp.origem.id | 2-s2.0-85014815383 | |
hcfmusp.publisher.city | PHILADELPHIA | |
hcfmusp.publisher.country | USA | |
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dc.description.index | MEDLINE | |
dc.identifier.eissn | 1532-866X | |
hcfmusp.citation.scopus | 9 | |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - ODS/03 |
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