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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | DOLAN, E. | - |
dc.contributor.author | SAUNDERS, B. | - |
dc.contributor.author | DANTAS, W. S. | - |
dc.contributor.author | MURAI, I. H. | - |
dc.contributor.author | ROSCHEL, H. | - |
dc.contributor.author | ARTIOLI, G. G. | - |
dc.contributor.author | HARRIS, R. | - |
dc.contributor.author | BICUDO, J. E. P. W. | - |
dc.contributor.author | SALE, C. | - |
dc.contributor.author | GUALANO, B. | - |
dc.date.accessioned | 2018-11-21T17:00:08Z | - |
dc.date.available | 2018-11-21T17:00:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.8, article ID 14788, 9p, 2018 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/29376 | - |
dc.description.abstract | Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we employed a comparative physiology approach to investigate the primary mechanism of HCD action in skeletal muscle. We selected two avian species (i.e., hummingbirds and chickens), who represented the extremes of the physiological processes in which HCDs are likely to function. Our findings indicate that HCDs are non-essential to the development of highly oxidative and contractile muscle, given their very low content in hummingbird skeletal tissue. In contrast, their abundance in the glycolytic chicken muscle, indicate that they are important in anaerobic bioenergetics as pH regulators. This evidence provides new insights on the HCD role in skeletal muscle, which could inform widespread interventions, from health to elite performance. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo to Bruno Gualano (FAPESP) [2013/14746-4] | - |
dc.description.sponsorship | FAPESP [2015/11328-2, 2017/09635-0, 2016/50438-0, 2017/04973-4, 2014/10859-1, 2016/10993-5] | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) | - |
dc.language.iso | eng | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | openAccess | - |
dc.subject.other | beta-alanine supplementation | - |
dc.subject.other | carnosine content | - |
dc.subject.other | chromatographic determination | - |
dc.subject.other | reactive oxygen | - |
dc.subject.other | fiber-type | - |
dc.subject.other | flight | - |
dc.subject.other | exercise | - |
dc.subject.other | performance | - |
dc.subject.other | anserine | - |
dc.subject.other | capacity | - |
dc.title | A Comparative Study of Hummingbirds and Chickens Provides Mechanistic Insight on the Histidine Containing Dipeptide Role in Skeletal Muscle Metabolism | - |
dc.type | article | - |
dc.rights.holder | Copyright NATURE PUBLISHING GROUP | - |
dc.identifier.doi | 10.1038/s41598-018-32636-3 | - |
dc.identifier.pmid | 30283073 | |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ARTIOLI, G. G.:Univ Sao Paulo, Rheumatol Div, Appl Physiol & Nutr Res Grp, Sao Paulo, SP, Brazil; Univ Sao Paulo, Fac Med, FMUSP, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | HARRIS, R.:Junipa Ltd, Newmarket, Suffolk, England | - |
hcfmusp.author.external | BICUDO, J. E. P. W.:Univ Wollongong, Sch Biol Sci, Wollongong, NSW, Australia | - |
hcfmusp.author.external | SALE, C.:Nottingham Trent Univ, Sport Hlth & Performance Enhancement Res Ctr, Nottingham, England; Nottingham Trent Univ, Musculoskeletal Physiol Res Grp, Nottingham, England; Nottingham Trent Univ, Sch Sci & Technol, Nottingham, England | - |
hcfmusp.description.articlenumber | 14788 | - |
hcfmusp.description.volume | 8 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000446339400072 | - |
hcfmusp.origem.id | 2-s2.0-85054387237 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 23 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - LIM/17 |
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