Oxidative Stress Parameters in Recent-Onset Bipolar Disorder and Possible Lithium Antioxidant Effect
Nenhuma Miniatura disponível
Citações na Scopus
Tipo de produção
conferenceObject
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Citação
BIOLOGICAL PSYCHIATRY, v.73, n.9, suppl.S, p.45S-45S, 2013
Resumo
Background: Several studies have shown oxidative stress (OxS) and imbalance of antioxidant enzymes in bipolar disorder (BD). Lithium is a gold-standard treatment in BD and showed a role in decreasing OxS. Despite few data available for recent-onset BD, increased antioxidant defenses were found in first episode of bipolar mania. No study, however, evaluated OxS parameters in depression of recent-onset BD and the effects of lithium treatment in OxS in bipolar depression. Methods: BD subjects in a depressive episode (n=25) with no more than 5 years of illness duration were enrolled and treated for 6 weeks with lithium monotherapy, although hypnotics use as needed was allowed. Blood samples were collected at baseline and after 6-week lithium treatment. Healthy controls (n=28) were used for comparison with patients. Tiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were measured spectrophotometrically. Results: BD patients had increased CAT (ANCOVA, df=1, 47, F=56.60, p<0.001), enhanced GPx (ANCOVA, df=1, 49, F=12.20, p=0.001) and decreased SOD/CAT ratio (ANCOVA, df=1, 44, F=30.66, p<0.001) compared to healthy controls. Also, no differences in SOD or TBARS between subjects with BD and healthy controls was observed. Regarding lithium treatment effects, BD patients had a decrease in TBARS (Wilcoxon Signed Ranks Test, z=-2.81, p=0.005) levels, with no changes in other parameters. Conclusions: Results suggest that recent-onset BD may have enhanced antioxidant enzymes. Lithium showed efficacy against OxS, confirming its neuroprotective role.
Palavras-chave
Bipolar Disorder, Oxidative Stress, Lithium, Antioxidant Enzymes, Neuroprotection