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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | RENDO-URTEAGA, Tara | |
dc.contributor.author | MORAES, Augusto Cesar Ferreira de | |
dc.contributor.author | TORRES-LEAL, Francisco Leonardo | |
dc.contributor.author | MANIOS, Yannis | |
dc.contributor.author | GOTTAND, Frederic | |
dc.contributor.author | SJOSTROM, Michael | |
dc.contributor.author | KAFATOS, Anthony | |
dc.contributor.author | WIDHALM, Kurt | |
dc.contributor.author | HENAUW, Stefaan De | |
dc.contributor.author | MOLNAR, Denes | |
dc.contributor.author | MARCOS, Ascension | |
dc.contributor.author | GONZALEZ-GROSS, Marcela | |
dc.contributor.author | FERRARI, Marika | |
dc.contributor.author | CARVALHO, Heractito B. | |
dc.contributor.author | MORENO, Luis A. | |
dc.date.accessioned | 2019-01-17T13:35:38Z | - |
dc.date.available | 2019-01-17T13:35:38Z | - |
dc.date.issued | 2018 | |
dc.identifier.citation | JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.31, n.11, p.1221-1229, 2018 | |
dc.identifier.issn | 0334-018X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/30023 | - |
dc.description.abstract | Background: Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods: A sample of 511 adolescents with EP (12.517.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed. Results: EP was positively associated with the atherogenic index (Ath-I) ((3=0.174; 95 0 /0CI 0.029-0.265) and negatively associated with the C-reactive protein (CRP) ([3=-0.284; 95%Cl -0.542 to -0.028) in girls. These associations were fully mediated by leptin levels (9.5%) and adiposity (44%), respectively. Moreover, EP has indirect effects on the apolipoprotein A-1 (ApoA-1) levels through adiposity in girls (for body mass index [BMI], 13= 0.014; 95%CI 0.005-0.028, and for waist circumference [WC], (3 = sloth 950/00 0.003-0.024), and on ApoA-1 ((3 = 0.012; 95%CI 0.004-0.025), apolipoprotein B (ApoB) (3= -0.004; 95%CI -0.011 to -0.0004) and CRP ([3=-0.265; 95%CI -0.819 to -0.047) through abdominal fat in boys. Conclusions: Leptin levels and adiposity seem to play an important indirect and mediation role in the association between EP and cardiometabolic and inflammatory markers in adolescents. Weight control should be recommended in order to control the impaired cardiometabolic and inflammatory status arising in early pubertal adolescents. | eng |
dc.description.sponsorship | European Community Sixth RTD Framework Programme [10.13039/100011103, FOOD-CT-2005-007034] | |
dc.description.sponsorship | Spanish Ministry of Health: Maternal, Child Health and Development Network [RD08/0072] | |
dc.description.sponsorship | Spanish Ministry of Education [EX-2008-0641] | |
dc.description.sponsorship | Swedish Heart-Lung Foundation [20090635] | |
dc.description.sponsorship | Spanish Ministry of Science and Innovation [JCI-2010-07055] | |
dc.description.sponsorship | Sao Paulo Research Foundation - FAPESP [10.13039/501100001807, 2014/25233-0, 2015/11406-3] | |
dc.description.sponsorship | National Counsel of Technological and Scientific Development (CNPq) [313772/2014-2] | |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP) [10.13039/501100001807, 2014/13367-2, 2015/14319-4, 2014/11468-6] | |
dc.description.sponsorship | European Regional Development Fund (MICINN-FEDER) | |
dc.language.iso | eng | |
dc.publisher | WALTER DE GRUYTER GMBH | eng |
dc.relation.ispartof | Journal of Pediatric Endocrinology & Metabolism | |
dc.rights | restrictedAccess | eng |
dc.subject | adiposity | eng |
dc.subject | adolescents | eng |
dc.subject | early puberty | eng |
dc.subject | indirect effect | eng |
dc.subject | leptin | eng |
dc.subject | mediation | eng |
dc.subject.other | healthy life-style | eng |
dc.subject.other | early menarche | eng |
dc.subject.other | body-composition | eng |
dc.subject.other | weight | eng |
dc.subject.other | children | eng |
dc.subject.other | inflammation | eng |
dc.subject.other | multicenter | eng |
dc.subject.other | childhood | eng |
dc.subject.other | nutrition | eng |
dc.subject.other | height | eng |
dc.title | Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study | eng |
dc.type | article | eng |
dc.rights.holder | Copyright WALTER DE GRUYTER GMBH | eng |
dc.contributor.groupauthor | HELENA Study Grp | |
dc.identifier.doi | 10.1515/jpem-2018-0120 | |
dc.identifier.pmid | 30325733 | |
dc.subject.wos | Endocrinology & Metabolism | eng |
dc.subject.wos | Pediatrics | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | TORRES-LEAL, Francisco Leonardo:Univ Fed Piaui, Metab Dis Exercise & Nutr DOMEN Res Grp, Teresina, Brazil | |
hcfmusp.author.external | MANIOS, Yannis:Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece | |
hcfmusp.author.external | GOTTAND, Frederic:Univ Lille 2, CHU Lille, Inserm U995, LIRIC,Hop J de Flandre, Lille, France | |
hcfmusp.author.external | SJOSTROM, Michael:Karolinska Inst, Dept Biosci & Nutr, Unit Prevent Nutr, Huddinge, Sweden | |
hcfmusp.author.external | KAFATOS, Anthony:Univ Crete, Sch Med, Prevent Med & Nutr Clin, Dept Social Med, Iraklion, Greece | |
hcfmusp.author.external | WIDHALM, Kurt:Private Med Univ, Dept Pediat, Salzburg, Austria; Med Univ Vienna, Dept Pediat, Salzburg, Austria | |
hcfmusp.author.external | HENAUW, Stefaan De:Univ Ghent, Dept Publ Hlth, Ghent, Belgium; Univ Coll Ghent Vesalius, Ghent, Belgium | |
hcfmusp.author.external | MOLNAR, Denes:Univ Pecs, Med Fac, Dept Pediat, Pecs, Hungary | |
hcfmusp.author.external | MARCOS, Ascension:CSIC, Inst Food Sci & Technol & Nutr ICTAN, Inst Frio, Dept Metab & Nutr,Inmunonutr Res Grp, Madrid, Spain | |
hcfmusp.author.external | GONZALEZ-GROSS, Marcela:Univ Politecn Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid, Spain; Rheinische Friedrich Wilhelms Univ, Inst Ernahrungs & Lebensmittelwissensch Ernahrung, Bonn, Germany | |
hcfmusp.author.external | FERRARI, Marika:Agr Res Council Roma, CRA NUT, Food & Nutr Res Ctr, Rome, Italy | |
hcfmusp.author.external | MORENO, Luis A.:Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, Fac Hlth Sci EUCS,CITA, Zaragoza, Spain; Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil | |
hcfmusp.description.beginpage | 1221 | |
hcfmusp.description.endpage | 1229 | |
hcfmusp.description.issue | 11 | |
hcfmusp.description.volume | 31 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000448690300007 | |
hcfmusp.origem.id | 2-s2.0-85055566352 | |
hcfmusp.publisher.city | BERLIN | eng |
hcfmusp.publisher.country | GERMANY | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 2191-0251 | |
hcfmusp.citation.scopus | 10 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 Artigos e Materiais de Revistas Científicas - LIM/39 Artigos e Materiais de Revistas Científicas - ODS/03 |
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