Resistance training downregulates macrophages infiltration in the kidney of 5/6 nephrectomized rats

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art_MORAES_Resistance_training_downregulates_macrophages_infiltration_in_the_kidney_2018.PDF (1.19 MB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
MORAES, Milton Rocha
ROSA, Thiago Santos
SOUZA, Michel Kendy
NEVES, Rodrigo Vanerson Passos
BACURAU, Reury Frank Pereira
PASSOS, Clevia Santos
CENEDEZE, Marcos Antonio
PASSOS, Michelle Tiveron
Citação
LIFE SCIENCES, v.213, p.190-197, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: Chronic kidney disease (CKD) is considered a significant world health problem with elevated mortality rates. Patients with CKD are restricted to mild physical activity, present chronic inflammatory state and loss of muscle strength. Currently, the influence of resistance exercise (RE) on the progression of renal disease has not being fully elucidated. Purpose: To evaluate the effects of RE on the progression of CKD in a remnant kidney model (5/6Nx) in rats. Methods: Eight-week-old Wistar rats were submitted to 5/6 nephrectomy and were divided into four groups: Sham sedentary (Sham SD); Sham RE (Sham RE); 5/6Nx SD and 5/6Nx RE. The animals were trained for 8 weeks in a vertical climbing ladder for 3 days per week, on non-consecutive days. Results: As expected, 5/6Nx SD group presented a markedly loss of renal function, increased plasma inflammatory cytokines and increased oxidative stress with a reduced activity of nitric oxide. The higher macrophage infiltration and fibrosis confirmed these conditions. RE attenuated systolic blood pressure and renal function decrease and also improved serum lipid parameters in 5/6 Nx animals. It was evident the increase of muscle strength and mass in the trained groups while the sedentary group showed reduced muscle weight and strength compared to Sham SD. Conclusions: RE implemented following 5/6Nx retard the progression of chronic kidney injury while simultaneously allowed the maintenance of skeletal muscle strength.
Palavras-chave
Resistance exercise, Inflammation, Muscle strength, Renal function, 5/6 nephrectomy
URI
https://observatorio.fm.usp.br/handle/OPI/30077
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - ODS/03