Vertebral artery stenosis in the Basilar Artery International Cooperation Study (BASICS): prevalence and outcome
Carregando...
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2015
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
COMPTER, Annette
HOEVEN, Erik J. R. J. van der
WORP, H. Bart van der
VOS, Jan Albert
WEIMAR, Christian
RUECKERT, Christina M.
KAPPELLE, L. Jaap
ALGRA, Ale
SCHONEWILLE, Wouter J.
Citação
JOURNAL OF NEUROLOGY, v.262, n.2, p.410-417, 2015
Resumo
We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of the intracranial VAs was available. In 72 patients an additional CTA of the extracranial VAs was available. Adjusted risk ratios (aRRs) for death and poor outcome, defined as a modified Rankin Scale score a parts per thousand yen4, were calculated with Poisson regression in relation to VA occlusion, VA occlusion or stenosis a parts per thousand yen50 %, and bilateral VA occlusion. Sixty-six of 141 (47 %) patients had uni- or bilateral intracranial VA occlusion or stenosis a parts per thousand yen50 %. Of the 72 patients with intra- and extracranial CTA, 46 (64 %) had uni- or bilateral VA occlusion or stenosis a parts per thousand yen50 % and 9 (12 %) had bilateral VA occlusion. Overall, VA occlusion or stenosis a parts per thousand yen50 % was not associated with the risk of poor outcome. Patients with intra- and extracranial CTA and bilateral VA occlusion had a higher risk of poor outcome than patients without bilateral VA occlusion (aRR, 1.23; 95 % CI 1.02-1.50). The risk of death did not depend on the presence of unilateral or bilateral VA occlusion or stenosis a parts per thousand yen50 %. In conclusion, in patients with acute BAO, unilateral VA occlusion or stenosis a parts per thousand yen50 % is frequent, but not associated with an increased risk of poor outcome or death. Patients with BAO and bilateral VA occlusion have a slightly increased risk of poor outcome.
Palavras-chave
Acute stroke, Vertebrobasilar disease, Atherosclerosis, Basilar artery occlusion
Referências
- Brandt T, 1996, STROKE, V27, P875, DOI 10.1161/01.STR.27.5.875
- Caplan Lr, 2005, J Clin Neurol, V1, P14, DOI 10.3988/jcn.2005.1.1.14
- Cloud Geoffrey C., 2004, Curr Treat Options Cardiovasc Med, V6, P121, DOI 10.1007/s11936-004-0040-5
- Compter A, 2008, TRIALS, V9, DOI 10.1186/1745-6215-9-65
- Devuyst G, 2002, ARCH NEUROL-CHICAGO, V59, P567, DOI 10.1001/archneur.59.4.567
- Greenland S, 1995, AM J EPIDEMIOL, V142, P1255, DOI 10.1093/oxfordjournals.aje.a117592
- Gulli G, 2009, STROKE, V40, P2732, DOI 10.1161/STROKEAHA.109.553859
- Khan S, 2007, J NEUROL NEUROSUR PS, V78, P1218, DOI 10.1136/jnnp.2006.111716
- Khan S, 2009, STROKE, V40, P3499, DOI 10.1161/STROKEAHA.109.556035
- Markus HS, 2013, LANCET NEUROL, V12, P989, DOI 10.1016/S1474-4422(13)70211-4
- Park JH, 2007, J NEUROL NEUROSUR PS, V78, P954, DOI 10.1136/jnnp.2006.105767
- Puetz V, 2008, INT J STROKE, V3, P230, DOI 10.1111/j.1747-4949.2008.00221.x
- Rothwell PM, 2003, LANCET, V361, P107, DOI 10.1016/S0140-6736(03)12228-3
- Schonewille WJ, 2005, J NEUROL NEUROSUR PS, V76, P1238, DOI 10.1136/jnnp.2004.049924
- Schonewille WJ, 2007, INT J STROKE, V2, P220, DOI 10.1111/j.1747-4949.2007.00145.x
- Schonewille WJ, 2009, LANCET NEUROL, V8, P724, DOI 10.1016/S1474-4422(09)70173-5
- van der Hoeven EJRJ, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-200
- Voetsch B, 2004, ARCH NEUROL-CHICAGO, V61, P496, DOI 10.1001/archneur.61.4.496