Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea

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art_DUQUE-CHICA_Contributions_of_the_MelanopsinExpressing_Ganglion_Cells_Cones_and_2019.PDF (985.82 KB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Autores
DUQUE-CHICA, Gloria L.
GRACITELLI, Carolina P. B.
MOURA, Ana L. A.
NAGY, Balazs V.
VIDAL, Kallene S.
MELO, Geraldine de
PARANHOS JR., Augusto
VENTURA, Dora F.
Citação
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v.60, n.8, p.3002-3012, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
PURPOSE. To investigate the impact of obstructive sleep apnea (OSA) on the contribution of inner and outer retinal photoreceptors to the pupillary light response (PLR). METHODS. Ninety-three eyes from 27 patients with OSA and 25 healthy controls were tested. OSA severity was graded according to the apnea-hypopnea index. PLR was measured monocularly with an eye tracker in a Ganzfeld in response to 1-second blue (470 nm) and red (640 nm) flashes at -3, -2, -1, 0, 1, 2, and 2.4 log cd/m(2). Peak pupil constriction amplitude, peak latency, and the postillumination pupil response were measured. The Cambridge Colour Test, standard automatic perimetry, spectral domain optical coherence tomography, polysomnography, and the Pittsburgh Sleep Quality Index were used. RESULTS. OSA patients have a significantly decreased peak pupil constriction amplitude for blue stimuli at -3, -2, -1, 1 log cd/m(2) and at all red flash luminances (P < 0.050), revealing reduction of outer retina contributions to PLR. OSA patients showed reduced peak latency for blue (-2, 0, 2, 2.4 log cd/m(2)) and red stimuli (-2, 0 log cd/m(2); P < 0.040). No significant difference was found in the melanopsin-mediated PLR. CONCLUSIONS. This study is the first to evaluate the inner and outer retinal contributions to PLR in OSA patients. The results showed that the outer retinal photoreceptor contributions to PLR were affected in moderate and severe OSA patients. In contrast, the inner retina contributions to PLR are preserved.
Palavras-chave
obstructive sleep apnea, pupillary light responses, classical photoreceptors, intrinsically photosensitive retinal ganglion cells, circadian rhythm, retinal nerve fiber layer thickness, visual field defect
URI
https://observatorio.fm.usp.br/handle/OPI/33231
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/32