Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/33948
Title: Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia
Authors: LUCENA-ARAUJO, Antonio R.COELHO-SILVA, Juan L.PEREIRA-MARTINS, Diego A.SILVEIRA, Douglas R.KOURY, Luisa C.MELO, Raul A. M.BITTENCOURT, RosanePAGNANO, KatiaPASQUINI, RicardoNUNES, Elenaide C.FAGUNDES, Evandro M.GLORIA, Ana B.KERBAUY, FabioCHAUFFAILLE, Maria de LourdesBENDIT, IsraelROCHA, VandersonKEATING, ArmandTALLMAN, Martin S.RIBEIRO, Raul C.DILLON, RichardGANSER, ArnoldLOWENBERG, BobVALK, P. J. M.LO-COCO, FrancescoSANZ, Miguel A.BERLINER, NancyREGO, Eduardo M.
Citation: BLOOD, v.132, n.12, p.951-959, 2019
Abstract: By combining the analysis of mutations with aberrant expression of genes previously related to poorer prognosis in both acute promyelocytic leukemia (APL) and acute myeloid leukemia, we arrived at an integrative score in APL (ISAPL) and demonstrated its relationship with clinical outcomes of patients treated with all-trans retinoic acid (ATRA) in combination with anthracycline-based chemotherapy. Based on fms-like tyrosine kinase-3-internal tandem duplication mutational status; the Delta Np73/TAp73 expression ratio; and ID1, BAALC, ERG, and KMT2E gene expression levels, we modeled ISAPL in 159 patients (median ISAPL score, 3; range, 0-10). ISAPL modeling identified 2 distinct groups of patients, with significant differences in early mortality (P <.001), remission (P = .004), overall survival (P < .001), cumulative incidence of relapse (P = .028), disease-free survival (P = .03), and event-free survival (P < .001). These data were internally validated by using a bootstrap resampling procedure. At least for patients treated with ATRA and anthracycline-based chemotherapy, ISAPL modeling may identify those who need to be treated differently to maximize their chances for a cure.
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/31
LIM/31 - Laboratório de Genética e Hematologia Molecular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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