https://observatorio.fm.usp.br/handle/OPI/35817
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MARCHESI, Raquel F. | |
dc.contributor.author | VELLOSO, Elvira D. R. P. | |
dc.contributor.author | GARANITO, Marlene P. | |
dc.contributor.author | LEAL, Aline M. | |
dc.contributor.author | SIQUEIRA, Sheila A. C. | |
dc.contributor.author | AZEVEDO NETO, Raymundo S. | |
dc.contributor.author | ROCHA, Vanderson | |
dc.contributor.author | ZERBINI, Maria Claudia N. | |
dc.date.accessioned | 2020-06-01T14:46:36Z | - |
dc.date.available | 2020-06-01T14:46:36Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | ANNALS OF DIAGNOSTIC PATHOLOGY, v.45, article ID UNSP 151459, 8p, 2020 | |
dc.identifier.issn | 1092-9134 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/35817 | - |
dc.description.abstract | Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function, which can progress to myelodysplastic syndrome (MDS) or to acute myeloid leukemia (AML). To determine if there are characteristics in bone marrow biopsies in children and adults previously diagnosed with acquired AA, which could predict progression to MDS, we evaluated 118 hypocellular bone marrow biopsies from adults (76 patients) and children (42) diagnosed initially with acquired AA previously to any treatment. Histology was reviewed according to a detailed protocol including Bennett and Orazi criteria for hypocellular myelodysplastic syndrome (h-MDS) and Bauman et al. criteria for refractory cytopenia of childhood (RCC). Twelve patients (10.2%; 6 children and 6 adults) progressed to MDS after a median time of 56 months. Criteria described by Bennett and Orazi suggestive of h-MDS in bone marrow biopsies were detected in 16 cases (13.5%; 8 adults and 8 children), and none in patients that progressed to MDS/AML. Twenty adults' biopsies (26.3%) had the histological criteria used for the diagnosis of pediatric RCC, and none showed MDS/AML evolution. Ten children (23.8%) were reclassified morphologically as RCC, and only one progressed to MDS. In this population with acquired aplastic anemia (AAA), no histological/immunohistochemical (H/IHC) bone marrow findings could discriminate patients with higher risk for myeloid clonal progression, which questions the diagnosis of h-MDS/RCC based only on the finding of dysplasia in the cases without increased blasts and/or the characteristic genetic abnormalities. | eng |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP), BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | eng |
dc.relation.ispartof | Annals of Diagnostic Pathology | |
dc.rights | restrictedAccess | eng |
dc.subject | Acquired aplastic anemia | eng |
dc.subject | Bone marrow failure | eng |
dc.subject | Hypocellular myelodysplastic syndrome | eng |
dc.subject | Refractory cytopenia of childhood | eng |
dc.subject | Acute myeloid leukemia | eng |
dc.subject | Bone marrow biopsy | eng |
dc.subject.other | hypoplastic myelodysplastic syndrome | eng |
dc.subject.other | refractory cytopenia | eng |
dc.subject.other | clonal hematopoiesis | eng |
dc.subject.other | somatic mutations | eng |
dc.subject.other | childhood | eng |
dc.subject.other | diagnosis | eng |
dc.subject.other | immunohistochemistry | eng |
dc.subject.other | management | eng |
dc.subject.other | pathophysiology | eng |
dc.subject.other | guidelines | eng |
dc.title | Clinical impact of dysplastic changes in acquired aplastic anemia: A systematic study of bone marrow biopsies in children and adults | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | eng |
dc.identifier.doi | 10.1016/j.anndiagpath.2019.151459 | |
dc.identifier.pmid | 32000075 | |
dc.subject.wos | Pathology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.description.articlenumber | UNSP 151459 | |
hcfmusp.description.volume | 45 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000527850100009 | |
hcfmusp.origem.id | 2-s2.0-85078239962 | |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1532-8198 | |
hcfmusp.citation.scopus | 2 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/01 Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/31 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_MARCHESI_Clinical_impact_of_dysplastic_changes_in_acquired_aplastic_2020.PDF.pdf Restricted Access | publishedVersion (English) | 1.41 MB | Adobe PDF | View/Open Request a copy |
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