Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

Imagem de Miniatura
Arquivos
art_TEIXEIRA_MaternalFetal_Interplay_in_Zika_Virus_Infection_and_Adverse_2020.PDF (717.17 KB)
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
Citação
FRONTIERS IN IMMUNOLOGY, v.11, article ID 175, 15p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause congenital damage to the fetus. Recently, Zika virus (ZIKV) infection has gained great notoriety due to the occurrence of congenital ZIKV syndrome, characterized by fetal microcephaly, which results from the ability of ZIKV to infect placental cells and neural precursors in the fetus. Importantly, in addition to the congenital effects, studies have shown that perinatal ZIKV infection causes a number of disorders, including maculopapular rash, conjunctivitis, and arthralgia. In this paper, we contextualize the immunological aspects involved in the maternal-fetal interface and vulnerability to ZIKV infection, especially the alterations resulting in perinatal outcomes. This highlights the need to develop protective maternal vaccine strategies or interventions that are capable of preventing fetal or even neonatal infection.
Palavras-chave
maternal-fetal, neonatal, Zika virus, adverse effects, congenital infections
URI
https://observatorio.fm.usp.br/handle/OPI/35925
Referências
  1. Abbink P, 2016, SCIENCE, V353, P1129, DOI 10.1126/science.aah6157
  2. Adamski A, 2018, J INFECTION, V76, P529, DOI 10.1016/j.jinf.2018.02.010
  3. Adkins B, 2004, NAT REV IMMUNOL, V4, P553, DOI 10.1038/nri1394
  4. Aksoy E, 2007, BLOOD, V109, P2887, DOI 10.1182/blood-2006-06-027862
  5. Alam A, 2016, IMMUNOLOGY, V149, P386, DOI 10.1111/imm.12656
  6. Alimonti JB, 2018, FLUIDS BARRIERS CNS, V15, DOI 10.1186/s12987-018-0100-y
  7. Anderson T, 2019, B WORLD HEALTH ORGAN, V97, P6, DOI 10.2471/BLT.19.020119
  8. ARAGAO MDV, 2016, [No title captured], V353, DOI 10.1136/BMJ.I2444
  9. Ashwal S, 2009, NEUROLOGY, V73, P887, DOI 10.1212/WNL.0b013e3181b783f7
  10. Askelund K, 2004, PLACENTA, V25, P140, DOI 10.1016/S0143-4004(03)00182-6
  11. ATHANASSAKIS I, 1995, AM J REPROD IMMUNOL, V34, P281, DOI 10.1111/j.1600-0897.1995.tb00954.x
  12. Avelino-Silva VL, 2018, REV INST MED TROP SP, V60, DOI [10.1590/S1678-9946201860064, 10.1590/s1678-9946201860064]
  13. BARKOVICH AJ, 1994, AM J NEURORADIOL, V15, P703
  14. Barrett ADT, 2018, NPJ VACCINES, V3, DOI 10.1038/s41541-018-0061-9
  15. Barthel A, 2013, CLIN INFECT DIS, V57, P415, DOI 10.1093/cid/cit227
  16. Basurko C, 2009, EUR J OBSTET GYN R B, V147, P29, DOI 10.1016/j.ejogrb.2009.06.028
  17. Bayer A, 2016, CELL HOST MICROBE, V19, P705, DOI 10.1016/j.chom.2016.03.008
  18. Bentlin MR, 2011, EMERG INFECT DIS, V17, P1779, DOI 10.3201/eid1709.110242
  19. Besnard M, 2014, EUROSURVEILLANCE, V19, P13, DOI 10.2807/1560-7917.ES2014.19.13.20751
  20. Bhatnagar J, 2017, EMERG INFECT DIS, V23, P405, DOI 10.3201/eid2303.161499
  21. Blohm GM, 2018, CLIN INFECT DIS, V66, P1120, DOI 10.1093/cid/cix968
  22. BORTHWICK GM, 1988, PLACENTA, V9, P81, DOI 10.1016/0143-4004(88)90075-6
  23. Bot A, 1997, INT IMMUNOL, V9, P1641, DOI 10.1093/intimm/9.11.1641
  24. Brasil P, 2016, NEW ENGL J MED, V375, P2321, DOI 10.1056/NEJMoa1602412
  25. Brito CAA, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3313-4
  26. Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
  27. BULMER JN, 1991, HUM REPROD, V6, P791, DOI 10.1093/oxfordjournals.humrep.a137430
  28. Cavalcanti AFC, 2019, INT J PAEDIATR DENT, V29, P74, DOI 10.1111/ipd.12431
  29. CAIRESJUNIOR LC, 2018, NAT COMM, V0009
  30. Calvert C, 2014, NEW ENGL J MED, V371, P1075, DOI 10.1056/NEJMc1408436
  31. Castillo-Solorzano C, 2011, J INFECT DIS, V204, pS571, DOI 10.1093/infdis/jir472
  32. Centers for Disease Control and Prevention (CDC), 2002, MMWR Morb Mortal Wkly Rep, V51, P1135
  33. Cerdeira AS, 2013, J IMMUNOL, V190, P3939, DOI 10.4049/jimmunol.1202582
  34. CHAOUAT G, 1995, J IMMUNOL, V154, P4261
  35. Chiossone L, 2014, HAEMATOLOGICA, V99, P448, DOI 10.3324/haematol.2013.091421
  36. Chouin-Carneiro T, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004543
  37. Co EC, 2013, BIOL REPROD, V88, DOI 10.1095/biolreprod.112.099465
  38. Cohen J, 2017, SCIENCE, V357, P241, DOI 10.1126/science.357.6348.241
  39. Colt S, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005528
  40. Coyne CB, 2016, NAT REV MICROBIOL, V14, P707, DOI 10.1038/nrmicro.2016.125
  41. Cugola FR, 2016, NATURE, V534, P267, DOI 10.1038/nature18296
  42. Cupedo T, 2005, EUR J IMMUNOL, V35, P383, DOI 10.1002/eji.200425763
  43. Dang J, 2016, CELL STEM CELL, V19, P258, DOI 10.1016/j.stem.2016.04.014
  44. Danis B, 2008, EUR J IMMUNOL, V38, P507, DOI 10.1002/eji.200737760
  45. Darrasse-Jeze G, 2005, BLOOD, V105, P4715, DOI 10.1182/blood-2004-10-4051
  46. de Brito CA, 2009, IMMUNOTHERAPY-UK, V1, P883, DOI 10.2217/IMT.09.38
  47. de Noronha L, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02266
  48. Dollard SC, 2007, REV MED VIROL, V17, P355, DOI 10.1002/rmv.544
  49. Dupont-Rouzeyrol M, 2016, LANCET, V387, P1051, DOI 10.1016/S0140-6736(16)00624-3
  50. El Costa H, 2008, J IMMUNOL, V181, P3009, DOI 10.4049/jimmunol.181.5.3009
  51. El Costa H, 2016, SCI REP-UK, V6, DOI 10.1038/srep35296
  52. Faas MM, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00298
  53. Ferraris P, 2019, EMERG MICROBES INFEC, V8, P1003, DOI 10.1080/22221751.2019.1637283
  54. Freour T, 2016, EUROSURVEILLANCE, V21, P10, DOI 10.2807/1560-7917.ES.2016.21.23.30254
  55. Fu BQ, 2013, P NATL ACAD SCI USA, V110, pE231, DOI 10.1073/pnas.1206322110
  56. Gamliel M, 2018, IMMUNITY, V48, P951, DOI 10.1016/j.immuni.2018.03.030
  57. Gardner L, 2003, BIOL REPROD, V69, P1438, DOI 10.1095/biolreprod.103.017574
  58. Gerardin P, 2008, PLOS MED, V5, P413, DOI 10.1371/journal.pmed.0050060
  59. Ginhoux F, 2014, NAT REV IMMUNOL, V14, P392, DOI 10.1038/nri3671
  60. Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
  61. Giovanetti M, 2018, CLIN MICROBIOL INFEC, V24, P1111, DOI 10.1016/j.cmi.2018.06.008
  62. Goodman Alyson B, 2016, MMWR Morb Mortal Wkly Rep, V65, P1082, DOI 10.15585/mmwr.mm6539e2
  63. Grant A, 2016, CELL HOST MICROBE, V19, P882, DOI 10.1016/j.chom.2016.05.009
  64. Griffin I, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-2044
  65. Grischott F, 2016, TRAVEL MED INFECT DI, V14, P313, DOI 10.1016/j.tmaid.2016.07.002
  66. Haddow AD, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001477
  67. Hammack C, 2019, J VIROL, V93, DOI 10.1128/JVI.00638-19
  68. Hanners NW, 2016, CELL REP, V15, P2315, DOI 10.1016/j.celrep.2016.05.075
  69. Hasan SS, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14722
  70. Hastings AK, 2017, YALE J BIOL MED, V90, P325
  71. Haynes BF, 1998, IMMUNOL RES, V18, P175, DOI 10.1007/BF02788778
  72. Hazin AN, 2016, NEW ENGL J MED, V374, P2193, DOI 10.1056/NEJMc1603617
  73. Hills SL, 2016, MMWR-MORBID MORTAL W, V65, P215, DOI 10.15585/mmwr.mm6508e2
  74. Hoeffel G, 2012, J EXP MED, V209, P1167, DOI 10.1084/jem.20120340
  75. Holmes VA, 2003, CYTOKINE, V21, P265, DOI 10.1016/S1043-4666(03)00097-8
  76. Holt PG, 2000, ALLERGY, V55, P688, DOI 10.1034/j.1398-9995.2000.00118.x
  77. Hu BX, 2017, VIROL J, V14, DOI 10.1186/s12985-017-0882-6
  78. Hughes RAC, 1999, J NEUROIMMUNOL, V100, P74, DOI 10.1016/S0165-5728(99)00195-2
  79. Hunt JS, 2006, REPROD BIOL ENDOCRIN, V4, DOI 10.1186/1477-7827-4-S1-S10
  80. HUNT JS, 1987, J IMMUNOL, V138, P2481
  81. Ishitani A, 2006, J REPROD IMMUNOL, V69, P101, DOI 10.1016/j.jri.2005.10.004
  82. Jabrane-Ferrat N, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01397
  83. Carod-Artal FJ, 2018, EXPERT REV ANTI-INFE, V16, P399, DOI 10.1080/14787210.2018.1466702
  84. Joguet G, 2017, LANCET INFECT DIS, V17, P1200, DOI 10.1016/S1473-3099(17)30444-9
  85. Juch H, 2012, WIEN MED WOCHENSCHR, V162, P196, DOI 10.1007/s10354-012-0070-7
  86. Jung JY, 2016, IMMUNOLOGY, V149, P35, DOI 10.1111/imm.12625
  87. Kachikis A, 2016, J INFECTION, V72, pS83, DOI 10.1016/j.jinf.2016.04.027
  88. Kanswal S, 2008, J IMMUNOL, V181, P976, DOI 10.4049/jimmunol.181.2.976
  89. Karwowski MP, 2016, PEDIATRICS, V137, DOI 10.1542/peds.2016-0621
  90. Kenneson A, 2007, REV MED VIROL, V17, P253, DOI 10.1002/rmv.535
  91. King A, 2000, HUM REPROD UPDATE, V6, P28, DOI 10.1093/humupd/6.1.28
  92. Knuesel I, 2014, NAT REV NEUROL, V10, P643, DOI 10.1038/nrneurol.2014.187
  93. Kollmann TR, 2009, J IMMUNOL, V183, P7150, DOI 10.4049/jimmunol.0901481
  94. Koopman LA, 2003, J EXP MED, V198, P1201, DOI 10.1084/jem.20030305
  95. Kopcow HD, 2005, P NATL ACAD SCI USA, V102, P15563, DOI 10.1073/pnas.0507835102
  96. Kuno G, 2007, ARCH VIROL, V152, P687, DOI 10.1007/s00705-006-0903-z
  97. La Pine TR, 2003, PEDIATR RES, V54, P276, DOI 10.1203/01.PDR.0000072515.10652.87
  98. LABARRERE CA, 1990, TRANSPLANTATION, V50, P812, DOI 10.1097/00007890-199011000-00014
  99. Larocca RA, 2019, CELL HOST MICROBE, V26, P591, DOI 10.1016/j.chom.2019.10.001
  100. Larocca RA, 2016, NATURE, V536, P474, DOI 10.1038/nature18952
  101. Lash GE, 2006, J LEUKOCYTE BIOL, V80, P572, DOI 10.1189/jlb.0406250
  102. Laskarin G, 2008, AM J REPROD IMMUNOL, V59, P433, DOI 10.1111/j.1600-0897.2008.00599.x
  103. Leber A, 2010, AM J REPROD IMMUNOL, V63, P445, DOI 10.1111/j.1600-0897.2010.00821.x
  104. Lebov JF, 2019, BMC PREGNANCY CHILDB, V19, DOI 10.1186/s12884-019-2589-8
  105. Leite RC, 2014, J CLIN VIROL, V60, P16, DOI [10.1016/J.JCV.2014.02.009, 10.1016/j.jcv.2014.02.009]
  106. Magnani DM, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aan8184
  107. Mansuy JM, 2019, EMERG INFECT DIS, V25, P823, DOI 10.3201/eid2504.171886
  108. Marodi L, 2001, CLIN EXP IMMUNOL, V126, P456, DOI 10.1046/j.1365-2249.2001.01693.x
  109. Marques VD, 2019, PEDIATR NEUROL, V91, P3, DOI 10.1016/j.pediatrneurol.2018.11.003
  110. Matsuda K, 1996, J MED VIROL, V48, P199
  111. Matusali G, 2018, J CLIN INVEST, V128, P4697, DOI [10.1172/JCI121735, 10.1172/jci121735]
  112. McGovern N, 2017, NATURE, V546, P662, DOI 10.1038/nature22795
  113. Medin CL, 2017, ARCH PATHOL LAB MED, V141, P33, DOI 10.5858/arpa.2016-0409-RA
  114. Mehrjardi MZ, 2017, JPN J RADIOL, V35, P341, DOI 10.1007/s11604-017-0641-z
  115. Melo ASO, 2016, ULTRASOUND OBST GYN, V47, P6, DOI 10.1002/uog.15831
  116. Miner JJ, 2017, CELL HOST MICROBE, V21, P134, DOI 10.1016/j.chom.2017.01.004
  117. Miner JJ, 2016, CELL, V165, P1080, DOI 10.1016/j.cell.2016.05.008
  118. Ministerio da Saude B . Secretaria de Vigilancia em Saude, 2019, MIN SAUD B B EP, V22
  119. Miyazaki S, 2003, J LEUKOCYTE BIOL, V74, P514, DOI 10.1189/jlb.1102566
  120. Mlakar J, 2016, NEW ENGL J MED, V374, P951, DOI 10.1056/NEJMoa1600651
  121. Mold JE, 2008, SCIENCE, V322, P1562, DOI 10.1126/science.1164511
  122. Mor G, 2010, AM J REPROD IMMUNOL, V63, P425, DOI 10.1111/j.1600-0897.2010.00836.x
  123. Murphy SP, 1998, MOL REPROD DEV, V51, P1
  124. Naruse K, 2009, HUM REPROD, V24, P553, DOI 10.1093/humrep/den408
  125. Neu N, 2015, CLIN PERINATOL, V42, P77, DOI 10.1016/j.clp.2014.11.001
  126. Ngono AE, 2018, ANNU REV IMMUNOL, V36, P279, DOI 10.1146/annurev-immunol-042617-053142
  127. Nielsen-Saines K, 2019, NAT MED, V25, P1213, DOI 10.1038/s41591-019-0496-1
  128. Ning F, 2016, AM J REPROD IMMUNOL, V75, P298, DOI 10.1111/aji.12477
  129. Ohkawara T, 2015, BRAIN DEV-JPN, V37, P88, DOI 10.1016/j.braindev.2014.03.007
  130. Ostrander Betsy, 2019, Handb Clin Neurol, V162, P133, DOI 10.1016/B978-0-444-64029-1.00006-0
  131. PAHO/WHO Pan American Health Organization/World Health Organization, 2017, ZIK EP REP BRAZ
  132. Pardi N, 2017, NATURE, V543, P248, DOI 10.1038/nature21428
  133. Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
  134. Paul AM, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02028
  135. Paz-Bailey G, 2018, NEW ENGL J MED, V379, P1234, DOI 10.1056/NEJMoa1613108
  136. Pihlgren M, 2003, J IMMUNOL, V170, P2824, DOI 10.4049/jimmunol.170.6.2824
  137. Pinninti SG, 2018, SEMIN PERINATOL, V42, P168, DOI 10.1053/j.semperi.2018.02.004
  138. Plaks V, 2008, J CLIN INVEST, V118, P3954, DOI 10.1172/JCI36682
  139. Poland GA, 2018, LANCET INFECT DIS, V18, pE211, DOI 10.1016/S1473-3099(18)30063-X
  140. PrabhuDas M, 2015, NAT IMMUNOL, V16, P328, DOI 10.1038/ni.3131
  141. Prata-Barbos A, 2019, J PEDIAT-BRAZIL, V95, pS30, DOI 10.1016/j.jped.2018.10.016
  142. Prazeres J, 2016, BRAZIL JAMA OPHTHALM, V134, P529, DOI [DOI 10.1001/JAMA0PHTHALM0L.2016.0267, 10.1001/jamaophthalmol.2016.0267]
  143. Pridjian G, 2016, BIRTH DEFECTS RES A, V106, P716, DOI 10.1002/bdra.23523
  144. Prisant N, 2017, CLIN INFECT DIS, V64, P107, DOI 10.1093/cid/ciw669
  145. Quicke KM, 2016, CELL HOST MICROBE, V20, P83, DOI 10.1016/j.chom.2016.05.015
  146. Read JS, 2018, JAMA PEDIATR, V172, P686, DOI 10.1001/jamapediatrics.2018.0870
  147. Record M, 2014, PLACENTA, V35, P297, DOI 10.1016/j.placenta.2014.02.009
  148. Regla-Nava JA, 2019, PLOS NEGLECT TROP D, V13, DOI 10.1371/journal.pntd.0007080
  149. Renneson J, 2009, EUR J IMMUNOL, V39, P2789, DOI 10.1002/eji.200939414
  150. Reynolds MR, 2017, MMWR-MORBID MORTAL W, V66, P366, DOI 10.15585/mmwr.mm6613e1
  151. Rice ME, 2018, MMWR-MORBID MORTAL W, V67, P858, DOI 10.15585/mmwr.mm6731e1
  152. Richner JM, 2017, CELL, V170, P273, DOI 10.1016/j.cell.2017.06.040
  153. Rose S, 2007, J IMMUNOL, V178, P2667, DOI 10.4049/jimmunol.178.5.2667
  154. Rudolph MD, 2018, NAT NEUROSCI, V21, P765, DOI 10.1038/s41593-018-0128-y
  155. Salinas JL, 2017, J NEUROL SCI, V381, P272, DOI 10.1016/j.jns.2017.09.001
  156. Sapparapu G, 2016, NATURE, V540, P443, DOI 10.1038/nature20564
  157. Schneider C, 2014, NAT IMMUNOL, V15, P1026, DOI 10.1038/ni.3005
  158. Schumacher A, 2014, FRONT IMMUNOL, V5, P1, DOI 10.3389/fimmu.2014.00196
  159. Schumacher A, 2009, J IMMUNOL, V182, P5488, DOI 10.4049/jimmunol.0803177
  160. Schwartz DA, 2017, ARCH GYNECOL OBSTET, V295, P1361, DOI 10.1007/s00404-017-4361-5
  161. Selkov SA, 2013, PLACENTA, V34, P836, DOI 10.1016/j.placenta.2013.05.007
  162. Siegrist CA, 2001, VACCINE, V19, P3331, DOI 10.1016/S0264-410X(01)00028-7
  163. Siewiera J, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10183
  164. Siewiera J, 2013, PLOS PATHOG, V9, DOI 10.1371/journal.ppat.1003257
  165. Song BH, 2017, J NEUROIMMUNOL, V308, P50, DOI 10.1016/j.jneuroim.2017.03.001
  166. Sotelo JR, 2017, EMERG INFECT DIS, V23, P854, DOI 10.3201/eid2305.161538
  167. Sykes L, 2012, MEDIAT INFLAMM, V2012, DOI 10.1155/2012/967629
  168. Tabata T, 2016, CELL HOST MICROBE, V20, P155, DOI 10.1016/j.chom.2016.07.002
  169. Tai P, 2008, J CELL PHYSIOL, V214, P456, DOI 10.1002/jcp.21221
  170. Tai WB, 2018, EMERG MICROBES INFEC, V7, DOI 10.1038/s41426-017-0007-8
  171. Tan PC, 2008, OBSTET GYNECOL, V111, P1111, DOI 10.1097/AOG.0b013e31816a49fc
  172. Tang HL, 2016, CELL STEM CELL, V18, P587, DOI 10.1016/j.stem.2016.02.016
  173. Teixeira MG, 2016, AM J PUBLIC HEALTH, V106, P601, DOI 10.2105/AJPH.2016.303113
  174. Tilburgs T, 2008, J IMMUNOL, V180, P5737, DOI 10.4049/jimmunol.180.8.5737
  175. Tripathi S, 2017, PLOS PATHOG, V13, DOI 10.1371/journal.ppat.1006258
  176. Tripp RA, 2016, EXPERT REV VACCINES, V15, P1083, DOI 10.1080/14760584.2016.1192474
  177. Tsuda S, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01934
  178. United Nations Inter-agency Group for Child Mortality Estimation (UN IGME), 2019, LEV TRENDS CHILD MOR
  179. Vacca P, 2006, BLOOD, V108, P4078, DOI 10.1182/blood-2006-04-017343
  180. Valentine GC, 2018, AM J OBSTET GYNECOL, V219, DOI 10.1016/j.ajog.2018.06.005
  181. Vermillion MS, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14575
  182. Vesnaver TV, 2017, BJOG-INT J OBSTET GY, V124, P521, DOI 10.1111/1471-0528.14423
  183. Walteros DM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220049
  184. Wang R, 2018, VACCINE, V36, P3522, DOI 10.1016/j.vaccine.2018.04.051
  185. Wang SC, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1642-x
  186. Webster RB, 2007, J BIOL CHEM, V282, P700, DOI 10.1074/jbc.M609501200
  187. WHO World Health Organization, 2019, WHO VACC PIP TRACK
  188. Winterberg T, 2015, EUR J IMMUNOL, V45, P214, DOI 10.1002/eji.201444468
  189. Wong PSJ, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002348
  190. Yang SW, 2017, J REPROD IMMUNOL, V124, P30, DOI 10.1016/j.jri.2017.09.012
  191. Yockey LJ, 2016, CELL, V166, P1247, DOI 10.1016/j.cell.2016.08.004
  192. Yuan L, 2017, SCIENCE, V358, P933, DOI 10.1126/science.aam7120
  193. Zhang XM, 2017, NAT REV IMMUNOL, V17, P495, DOI 10.1038/nri.2017.54
  194. Zhang ZW, 2017, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00206
  195. Zhao JX, 2007, J REPROD IMMUNOL, V75, P71, DOI 10.1016/j.jri.2007.06.052
  196. Zhou WS, 2019, EMERG MICROBES INFEC, V8, P307, DOI 10.1080/22221751.2019.1578188
  197. Zhu XL, 2018, ACTA NEUROPATHOL COM, V6, DOI 10.1186/s40478-018-0572-7
  198. Zorrilla CD, 2017, J INFECT DIS, V216, pS891, DOI 10.1093/infdis/jix448

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - LIM/56
Artigos e Materiais de Revistas Científicas - ODS/03