Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy

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art_SISTI_Proinflammatory_mediators_in_vaginal_fluid_and_short_cervical_2020.PDF (152.1 KB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
COMENIUS UNIV
Autores
SISTI, G.
PACCOSI, S.
PARENTI, A.
SERAVALLI, V
LINARI, C.
TOMMASO, M. Di
Citação
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, v.121, n.4, p.278-281, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
AIM: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in inflammatory responses, correlated with a short cervix in pregnant women. METHODS: This prospective cohort study used a convenience sample of 64 women in their early third trimester with a singleton pregnancy. A short cervical length was present in 35 women (54.7 %). Vaginal fluid was tested for levels of MMP-8, IL-8 and hsp70 by enzyme-linked immunosorbent assay (ELISA). A receiver operating charasteristic (ROC) analysis was used to calculate the area under the curve (AUC) for each mediator in predicting short cervical length. RESULTS: MMP-8 (109 vs 29.6 ng/ml, p=0.014), IL-8 (689 vs 330 pg/ml, p=0.007) and hsp70 (4.4 vs 2.9 ng/ml, p=0.036) were all elevated in vaginal samples from women with a short cervix. In addition, there was a negative association between the concentration of each compound in vaginal fluid and cervical length p <= 0.026). The vaginal IL-8 concentration had the highest negative correlation with a short cervix (AUC=0.7, p=0.007). CONCLUSION: MMP-8, hsp70 and IL-8 contribute to a pro-inflammatory cervico-vaginal milieu that weakens cervical integrity and leads to a shortening in cervical length (Tab. 4, Fig. 1, Ref. 27). Text in PDF www.elis.sk.
Palavras-chave
cervical length, heat shock protein, interleukin-8, matrix metalloproteinase-8, vaginal fluid
URI
https://observatorio.fm.usp.br/handle/OPI/36317
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/58