LIM/12 - Laboratório de Pesquisa Básica em Doenças Renais
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Uric Acid Oxidation Products Correlate with Sepsis and Promote Modification on Serum Albumin in Intensive Care Unit Patients
FREE RADICAL BIOLOGY AND MEDICINE, v.208, suppl.1, p.S48-S49, 2023
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Single High-dose of Liposomal Amphotericin B in Human Immunodeficiency Virus (HIV)/AIDS-related Disseminated Histoplasmosis: A Randomized Trial
CLINICAL INFECTIOUS DISEASES, v.77, n.8, p.1126-1132, 2023
This is the first trial to demonstrate that AIDS patients with disseminated histoplasmosis can be safely and effectively treated with a single high dose of liposomal amphotericin B (10 mg/kg). Background Histoplasmosis is a major AIDS-defining illness in Latin America. Liposomal amphotericin B (L...
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The impact of obesity in hospitalized patients with COVID-19: a retrospective cohort study
DIABETOLOGY & METABOLIC SYNDROME, v.16, n.1, article ID 20, 7p, 2024
Background Obesity is believed to be a risk factor for COVID-19 and unfavorable outcomes, although data on this remains to be better elucidated.Objective To evaluate the impact of obesity on the endpoints of patients hospitalized due to SARS-CoV-2.Methods This retrospective cohort study evaluated...
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Substance used in the ripening of fruits can cause kidney damage and water and electrolytic disorders
JORNAL BRASILEIRO DE NEFROLOGIA, v.45, n.4, p.387-388, 2023
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Critically ill patients with COVID-19-associated acute kidney injury treated with kidney replacement therapy: Comparison between the first and second pandemic waves in São Paulo, Brazil
PLOS ONE, v.18, n.11, article ID e0293846, 16p, 2023
IntroductionThis study aimed to compare the characteristics and outcomes of critically ill patients with COVID-19-associated acute kidney injury (AKI) who were treated with kidney replacement therapy (KRT) in the first and second waves of the pandemic in the megalopolis of Sao Paulo, Brazil.Metho...
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A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)
CLINICS, v.78, article ID 100280, 10p, 2023
Introduction: Ideal timing of Renal Replacement Therapy (RRT) discontinuation in Acute Kidney Injury (AKI) is still unknown. We aimed to study the role of creatinine-related variables in predicting RRT successful discontinuation and to propose a clinical predictive score.Methods: In this single-c...
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TREATMENT WITH HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS IN A PIG MODEL OF SEPSIS-INDUCED ACUTE KIDNEY INJURY: EFFECTS ON MICROVASCULAR ENDOTHELIAL CELLS AND TUBULAR CELLS IN THE KIDNEY
SHOCK, v.60, n.3, p.469-477, 2023
Background: Approximately 50% of patients with sepsis develop acute kidney injury (AKI), which is predictive of poor outcomes, with mortality rates of up to 70%. The endothelium is a major target for treatments aimed at preventing the complications of sepsis. We hypothesized that human umbilical ...
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Can a Therapeutic Strategy for Hypotension Improve Cerebral Perfusion and Oxygenation in an Experimental Model of Hemorrhagic Shock and Severe Traumatic Brain Injury?
NEUROCRITICAL CARE, v.39, n.2, p.320-330, 2023
BackgroundRestoration of brain tissue perfusion is a determining factor in the neurological evolution of patients with traumatic brain injury (TBI) and hemorrhagic shock (HS). In a porcine model of HS without neurological damage, it was observed that the use of fluids or vasoactive drugs was effe...
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Administration of a single dose of lithium ameliorates rhabdomyolysis-associated acute kidney injury in rats
PLOS ONE, v.18, n.2, article ID e0281679, 19p, 2023
Rhabdomyolysis is characterized by muscle damage and leads to acute kidney injury (AKI). Clinical and experimental studies suggest that glycogen synthase kinase 3 beta (GSK3 beta) inhibition protects against AKI basically through its critical role in tubular epithelial cell apoptosis, inflammatio...
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International Perspectives on GFR Estimation and Race-Based Adjustments
CLINICAL CHEMISTRY, v.69, n.8, p.796-802, 2023
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