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https://observatorio.fm.usp.br/handle/OPI/36938
Title: | Galectin-3 Levels in Patients with Chronic Constrictive Pericarditis |
Authors: | FERNANDES, Fabio; MELO, Dirceu Thiago Pessoa de; RAMIRES, Felix Jose Alvarez; SABINO, Ester Cerdeira; MOREIRA, Carlos Henrique Valente; BENVENUTTI, Luiz Alberto; HOTTA, Viviane Remi; SAYEGH, Ana Luiza Carrari; SOUZA, Francis Ribeiro de; DIAS, Ricardo Ribeiro; MADY, Charles |
Citation: | ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.114, n.4, p.683-689, 2020 |
Abstract: | Background: Galectin-3 (Gal-3) is a proinflammatory, profibrotic molecule implicated in the pathogenesis of heart failure. The role of Gal-3 in patients with chronic constrictive pericarditis (CCP) is not clear. Objective: The aim of this study was to assess plasma Gal-3 in patients with CCP and correlate it with clinical, functional and histologic parameters. Methods: We prospectively evaluated 25 symptomatic patients with CCP referred for pericardiectomy and 21 healthy controls. Patients underwent clinical assessment, Gal-3 and B-type natriuretic peptide (BNP) measurements, echocardiography, cardiac magnetic resonance imaging and cardiopulmonary exercise test (CPET) at baseline. Six months after pericardiectomy CPET was repeated. An alpha error < 5% was considered statistically significant, with a confidence interval of 95%. Results: Twenty-five patients with a median age of 45 years were included. Etiology was mainly idiopathic (n = 19, 76%); and 14 (56%) patients had NYHA functional class III/IV. Median BNP and Gal-3 were 143 (89-209) pg/dL and 14.8 (9.7-17.2) ng/mL, respectively. Gal-3 levels were not significantly higher in CCP patients than in control (p = 0.22). There were no significant correlations of Gal-3 with BNP, echocardiographic and cardiac magnetic resonance measures and histological findings. After pericardiectomy, it was found a statistically significant correlation between Gal-3 and the CPTE measures test duration (r =-0.79; p < 0.001) and exercise time (r =-0.79; p < 0.001). Conclusions: Patients with CCP had normal levels of Gal-3 as compared to the controls. Gal-3 did not correlate with morphological and functional measures before pericardiectomy. However, the associations between Gal-3 and exercise intolerance after pericardiectomy may suggest a role of Gal-3 in prognosis prediction after pericardiectomy. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/11 Artigos e Materiais de Revistas Científicas - LIM/46 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_FERNANDES_Galectin3_Levels_in_Patients_with_Chronic_Constrictive_Pericarditis_2020.PDF | publishedVersion (English) | 364.64 kB | Adobe PDF | View/Open |
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