LIM/43 - Laboratório de Medicina Nuclear
URI Permanente desta comunidade
O Laboratório de Medicina Nuclear é ligado ao Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Linhas de pesquisa: análise crítica dos métodos de neuroimagem funcional na avaliação das desordens neurológicas e psiquiátricas; medicina nuclear e aplicação clínica dos radioisótopos.
Site oficial: http://limhc.fm.usp.br/portal/lim43-laboratorio-de-medicina-nuclear/
Linhas de pesquisa: análise crítica dos métodos de neuroimagem funcional na avaliação das desordens neurológicas e psiquiátricas; medicina nuclear e aplicação clínica dos radioisótopos.
Site oficial: http://limhc.fm.usp.br/portal/lim43-laboratorio-de-medicina-nuclear/
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Scopus: 35
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Coleções desta Comunidade
- LIM/43 - Laboratório de Medicina Nuclear
- LIM/43 - Laboratório de Medicina Nuclear
- LIM/43 - Laboratório de Medicina Nuclear
Submissões Recentes
Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo
(2022) KE, W.; CHANDLER, M.; CEDRONE, E.; SAITO, R. F.; RANGEL, M. C.; JUNQUEIRA, M. De Souza; WANG, J.; SHI, D.; TRUONG, N.; RICHARDSON, M.; ROLBAND, L. A.; DRéAU, D.; BEDOCS, P.; CHAMMAS, R.; DOKHOLYAN, N. V.; DOBROVOLSKAIA, M. A.; AFONIN, K. A.
The unbalanced coagulation of blood is a life-threatening event that requires accurate and timely treatment. We introduce a user-friendly biomolecular platform based on modular RNA-DNA anticoagulant fibers programmed for reversible extracellular communication with thrombin and subsequent control of anticoagulation via a ""kill-switch""mechanism that restores hemostasis. To demonstrate the potential of this reconfigurable technology, we designed and tested a set of anticoagulant fibers that carry different thrombin-binding aptamers. All fibers are immunoquiescent, as confirmed in freshly collected human peripheral blood mononuclear cells. To assess interindividual variability, the anticoagulation is confirmed in the blood of human donors from the U.S. and Brazil. The anticoagulant fibers reveal superior anticoagulant activity and prolonged renal clearance in vivo in comparison to free aptamers. Finally, we confirm the efficacy of the ""kill-switch""mechanism in vivo in murine and porcine models.
Generating PET-derived maps of myelin content from clinical MRI using Generative Adversarial Networks
(2023) SOULIER, Theodore; HAMZAOUI, Mariem; PITOMBEIRA, Milena Sales; FARIA, Daniele; YAZDAN-PANAH, Arya; TONIETTO, Matteo; BOTTLAENDER, Michel; LEROY, Claire; BODINI, Benedetta; AYACHE, Nicholas; COLLIOT, Olivier; STANKOFF, Bruno
Metabolic and Structural Signatures in Corticobasal Syndrome: A Multimodal PET/MRI Study
(2021) CARNEIRO, G. C.; PARMERA, J. B.; ALMEIDA, I. J.; OLIVEIRA, M. C. B.; SILAGI, M. L.; STUDART-NETO, A.; ONO, C. R.; BARBOSA, E. R.; NITRINI, R.; BUCHPIGUEL, C. A.; BRUCKI, S. M. D.; COUTINHO, A. M.
Comparative analysis of image quality parameters in three PET systems in Brazil
(2021) GONTIJO, Rodrigo Modesto Gadelha; FERREIRA, Andrea Vidal; FARIA, Daniele de Paula; BUCHPIGUEL, Carlos Alberto; GREGGIO, Samuel; VENTURIN, Gianina Teribele; COSTA, Jaderson Costa da; SILVA, Juliana Batista da; MAMEDE, Marcelo
Effects of sulforaphane association to conventional therapy for treating triple-negative breast cancer
(2023) COUTINHO, L. L.; CHENG, R.; RIDNOUR, L.; JUNQUEIRA, M. S.; CHAMMAS, R.; WINK, D.; TORTELLI, T. C.; RANGEL, M.
Cyclotron Products Certified by a Public Hospital in Sao Paulo
(2021) OKAMOTO, Miriam Roseli Yoshie
Survival outcomes for patients (pts) with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with lutetium-177-dotatate (Lu-177) in a Brazilian reference center: A six-year follow-up experience.
(2023) SOUZA, Zenaide Silva; XAVIER, Camila Braganca; SIQUEIRA, Luciana Beatriz Mendes Gomes; MEDEIROS, Maria Fernanda Barbosa de; SOUZA, Micelange Carvalho de; BEGNAMI, Maria Dirlei de Souza; PEREIRA, Allan Andresson Lima; MARIN, Jose Flavio Gomes; BUCHPIGUEL, Carlos Alberto; COSTA, Frederico
Spinal Cord imaging by [11C]PIB PET/MRI: evaluation of drawing methods and reference region use in myelin uptake quantification of Healthy Volunteers and Multiple Sclerosis Patients
(2023) LUCENA, L. Zorante de; PITOMBEIRA, M. Sales; CAMPANHOLO, K. Repiso; BUCHPIGUEL, C. Alberto; FARIA, D. de Paula
Expanding the phenotypic spectrum of CLCN2-related leucoencephalopathy and ataxia
(2023) NOBREGA, Paulo R.; PAIVA, Anderson R. B. de; SOUZA, Katiane S.; SOUZA, Jorge Luiz B. de; LIMA, Pedro Lucas G. S. B.; SILVA, Delson Jose da; PITOMBEIRA, Milena Sales; BORGES, Viviennee K.; DIAS, Daniel A.; BISPO, Luciana M.; SANTOS, Carolina F.; FREUA, Fernando; SILVA, Paulo Diego S.; ALVES, Isabela S.; PORTELLA, Leonardo B.; CUNHA, Paulina R.; SALOMAO, Rubens Paulo A.; PEDROSO, Jose Luiz; MIYAJIMA, Veridiana P.; MIYAJIMA, Fabio; CALI, Elisa; WADE, Charles; SUDARSANAM, Annapurna; O'DRISCOLL, Mary; HAYTON, Tom; BARSOTTINI, Orlando G. P.; KLEBE, Stephan; KOK, Fernando; LUCATO, Leandro Tavares; HOULDEN, Henry; DEPIENNE, Christel; LYNCH, David S.; BRAGA-NETO, Pedro
Mutations in CLCN2 are a rare cause of autosomal recessive leucoencephalopathy with ataxia and specific imaging abnormalities. Very few cases have been reported to date. Here, we describe the clinical and imaging phenotype of 12 additional CLCN2 patients and expand the known phenotypic spectrum of this disorder. Informed consent was obtained for all patients. Patients underwent either whole-exome sequencing or focused/panel-based sequencing to identify variants. Twelve patients with biallelic CLCN2 variants are described. This includes three novel likely pathogenic missense variants. All patients demonstrated typical MRI changes, including hyperintensity on T2-weighted images in the posterior limbs of the internal capsules, midbrain cerebral peduncles, middle cerebellar peduncles and cerebral white matter. Clinical features included a variable combination of ataxia, headache, spasticity, seizures and other symptoms with a broad range of age of onset. This report is now the largest case series of patients with CLCN2-related leucoencephalopathy and reinforces the finding that, although the imaging appearance is uniform, the phenotypic expression of this disorder is highly heterogeneous. Our findings expand the phenotypic spectrum of CLCN2-related leucoencephalopathy by adding prominent seizures, severe spastic paraplegia and developmental delay. Nobrega et al. describe 12 additional CLCN2 leucoencephalopathy patients expanding the phenotypic spectrum by adding prominent seizures, severe spastic paraplegia and developmental delay. All patients demonstrated typical MRI changes. They found three novel missense variants. This report is now the largest case series of patients with CLCN2-related leucoencephalopathy. Graphical abstract
Cryoablation of Benign Thyroid Nodules: Preliminary Experience in 3 Cases
(2023) FREITAS, Ricardo Miguel Costa de; VANDERLEI, Felipe Augusto Brasileiro; ROSENFELD, Matheus Gerhard; BORGES, Alessandra de Pinho Pimenta; KOWALSKI, Luiz Paulo; CHAMMAS, Maria Cristina