Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment

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art_CORSI-ZUELLI_Cytokine_profile_in_firstepisode_psychosis_unaffected_siblings_and_2020.PDF (75.34 KB)
Citações na Scopus
41
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
CORSI-ZUELLI, Fabiana
LOUREIRO, Camila Marcelino
SHUHAMA, Rosana
FACHIM, Helene Aparecida
LOUZADA-JUNIOR, Paulo
MONDELLI, Valeria
DEL-BEN, Cristina Marta
Citação
PSYCHOLOGICAL MEDICINE, v.50, n.7, p.1139-1147, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Inflammation is a possible biological mechanism underlying the association between childhood maltreatment and psychosis. Previous investigations on this regard were mainly conducted on chronic schizophrenia and lacked control for confounders. We aim to investigate the role of familial liability, childhood maltreatment and recent stress in determining cytokine abnormalities at the onset of psychosis. Methods We recruited 114 first-episode psychosis (FEP) patients, 57 unaffected biological siblings of FEP patients, and 251 community-based controls. Plasma cytokines (IL-1 beta, IL-6, TNF-alpha, IFN-gamma, IL-4, IL-10 and TGF-beta) were measured and differences across the groups analysed after adjusting for potential confounders. Results FEP had a higher pro- and anti-inflammatory cytokine profile (IL-1 beta, IL-6, TNF-alpha, IL-10 and TGF-beta), which was not observed in unaffected siblings. Siblings presented decreased IL-1 beta when compared with patients and controls. Childhood maltreatment was associated with higher levels of TGF-beta in both patients and siblings when compared with controls. Physical childhood abuse was associated with increased levels of TGF-beta in FEP patients but with decreased levels in controls. Other childhood maltreatment subtypes or recent stressors did not affect cytokine levels in any of the groups. Conclusions Normal or reduced cytokines in siblings represent possibly a protective factor and suggest that the identified inflammatory profile in FEP can be a real pathophysiological component of psychosis. Experience of childhood maltreatment may contribute as long-term immune priming for the TGF-beta pathway, and increased levels of this cytokine in both patients and siblings exposed to childhood maltreatment point to a possible biological candidate of familial risk for psychosis.
Palavras-chave
Anti-inflammatory cytokines, childhood maltreatment, cytokines, early-life stress, first-episode psychosis, inflammation, pro-inflammatory cytokines, schizophrenia, siblings, transforming growth factor-beta
URI
https://observatorio.fm.usp.br/handle/OPI/37848
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/39
Artigos e Materiais de Revistas Científicas - ODS/16