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https://observatorio.fm.usp.br/handle/OPI/39080| Title: | Rheumatic Fever: A Model of Autoimmune Disease due to Molecular Mimicry between Human and Pathogen Proteins |
| Authors: | KALIL, Jorge; GUILHERME, Luiza |
| Citation: | CRITICAL REVIEWS IN IMMUNOLOGY, v.40, n.5, Special Issue, p.419-422, 2020 |
| Abstract: | Acute rheumatic fever (ARF) is caused by an autoimmune response to throat infection with Streptococcus pyogenes in individuals who present some susceptibility genes. Rheumatic heart disease (RHD) is the major sequela and can cause heart failure and premature mortality. The disease is mediated by humoral and cellular immune responses. In this review, we present the major events that can trigger heart lesions. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/19 Artigos e Materiais de Revistas Científicas - ODS/03 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| art_KALIL_Rheumatic_Fever_A_Model_of_Autoimmune_Disease_due_2020.PDF Restricted Access | publishedVersion (English) | 11.86 MB | Adobe PDF | View/Open Request a copy |
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