Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/3927
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | COELHO, Veronica | - |
dc.contributor.author | SAITOVITCH, David | - |
dc.contributor.author | KALIL, Jorge | - |
dc.contributor.author | SILVA, Hernandez Moura | - |
dc.date.accessioned | 2014-01-28T22:17:22Z | - |
dc.date.available | 2014-01-28T22:17:22Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | CURRENT OPINION IN ORGAN TRANSPLANTATION, v.18, n.1, p.13-21, 2013 | - |
dc.identifier.issn | 1087-2418 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/3927 | - |
dc.description.abstract | Purpose of review To discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and inflammatory (INFLAMMA) functions and to translate this knowledge for the development of novel immunomodulatory therapeutic strategies and to rethink the current ones. Recent findings Data from both experimental models and clinical trials point that B cells of various phenotypes have immunoregulatory activity and play an important role in controlling graft inflammation. Data on the state of operational tolerance, in kidney transplantation, suggest the relevance of preserving a healthy B-cell compartment - in numbers and in the Breg capacity to activate the CD40/STAT3 signalling pathway - for achieving and maintaining homeostasis. Moreover, autoantibodies also comprise transplant immunobiology and it seems that not all alloantibodies are deleterious. Summary The role of B cells, in organ transplantation, can no longer be taken as mere generators of plasma cells, which produce alloantibodies deleterious to the graft. B cells also seem to integrate a complex immunoregulatory network in organ transplantation, with Bregs of various phenotypes and possibly also antibodies. The functional discrimination of REG/INFLAMMA B-cell roles needs to be considered in the clinical setting. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/59290-7] | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq | - |
dc.description.sponsorship | iii/INCT) [573879-2008-7] | - |
dc.language.iso | eng | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.ispartof | Current Opinion in Organ Transplantation | - |
dc.rights | restrictedAccess | - |
dc.subject | alloantibodies | - |
dc.subject | autoantibodies | - |
dc.subject | B cells | - |
dc.subject | regulatory B cells | - |
dc.subject | reshaping the B-cell compartment | - |
dc.subject | transplantation tolerance | - |
dc.subject.other | renal-allograft recipients | - |
dc.subject.other | human-leukocyte antigen | - |
dc.subject.other | experimental autoimmune encephalomyelitis | - |
dc.subject.other | dose cyclosporine monotherapy | - |
dc.subject.other | antibody-mediated rejection | - |
dc.subject.other | primary graft dysfunction | - |
dc.subject.other | donor-specific antibodies | - |
dc.subject.other | regulatory t-cells | - |
dc.subject.other | operational tolerance | - |
dc.subject.other | hla antibodies | - |
dc.title | Rethinking the multiple roles of B cells in organ transplantation | - |
dc.type | article | - |
dc.rights.holder | Copyright LIPPINCOTT WILLIAMS & WILKINS | - |
dc.identifier.doi | 10.1097/MOT.0b013e32835c8043 | - |
dc.identifier.pmid | 23254702 | - |
dc.subject.wos | Transplantation | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SAITOVITCH, David:Natl Inst Sci & Technol INCT, III, Sao Paulo, Brazil; Pontificia Univ Catolica Rio Grande do Sul, Div Nephrol, Sao Lucas Hosp, Porto Alegre, RS, Brazil | - |
hcfmusp.description.beginpage | 13 | - |
hcfmusp.description.endpage | 21 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 18 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84872976616 | - |
hcfmusp.origem.id | WOS:000313963400003 | - |
hcfmusp.publisher.city | PHILADELPHIA | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Adis R&D Profile, 2010, DRUGS R D, V10, P55 | - |
hcfmusp.relation.reference | Ashton-Chess J, 2009, TRANSPLANTATION, V87, pS95, DOI 10.1097/TP.0b013e3181a2e295 | - |
hcfmusp.relation.reference | Azimzadeh AM, 2005, AM J TRANSPLANT, V5, P2349, DOI 10.1111/j.1600-6143.2005.01022.x | - |
hcfmusp.relation.reference | Battaglia M, 2006, J IMMUNOL, V177, P8338 | - |
hcfmusp.relation.reference | Becker YT, 2006, TRANSPLANT INT, V19, P621, DOI 10.1111/j.1432-2277.2006.00345.x | - |
hcfmusp.relation.reference | Blair PA, 2010, IMMUNITY, V32, P129, DOI 10.1016/j.immuni.2009.11.009 | - |
hcfmusp.relation.reference | Bloom D, 2009, AM J TRANSPLANT, V9, P1835, DOI 10.1111/j.1600-6143.2009.02710.x | - |
hcfmusp.relation.reference | Brouard S, 2007, P NATL ACAD SCI USA, V104, P15448, DOI 10.1073/pnas.0705834104 | - |
hcfmusp.relation.reference | Buggins AGS, 2002, BLOOD, V100, P1715 | - |
hcfmusp.relation.reference | Calne R, 1998, LANCET, V351, P1701, DOI 10.1016/S0140-6736(05)77739-4 | - |
hcfmusp.relation.reference | Calne R, 1999, TRANSPLANTATION, V68, P1613, DOI 10.1097/00007890-199911270-00032 | - |
hcfmusp.relation.reference | Cherukuri A, 2012, AM J TRANSPLANT, V12, P919, DOI 10.1111/j.1600-6143.2011.03891.x | - |
hcfmusp.relation.reference | Chong AS, 2011, AM J TRANSPLANT, V11, P2555, DOI 10.1111/j.1600-6143.2011.03773.x | - |
hcfmusp.relation.reference | Clatworthy MR, 2009, NEW ENGL J MED, V360, P2683, DOI 10.1056/NEJMc0808481 | - |
hcfmusp.relation.reference | Clatworthy MR, 2011, AM J TRANSPLANT, V11, P1359, DOI 10.1111/j.1600-6143.2011.03554.x | - |
hcfmusp.relation.reference | Cobbold S, 1998, CURR OPIN IMMUNOL, V10, P518, DOI 10.1016/S0952-7915(98)80217-3 | - |
hcfmusp.relation.reference | Cohen IR, 2007, NAT REV IMMUNOL, V7, P569, DOI 10.1038/nri2102 | - |
hcfmusp.relation.reference | Cohen IR, 2007, J AUTOIMMUN, V29, P246, DOI 10.1016/j.jaut.2007.07.016 | - |
hcfmusp.relation.reference | Crawford A, 2006, J IMMUNOL, V176, P3498 | - |
hcfmusp.relation.reference | Danger R, 2012, J AM SOC NEPHROL, V23, P597, DOI 10.1681/ASN.2011060543 | - |
hcfmusp.relation.reference | DiLillo DJ, 2011, J IMMUNOL, V186, P2643, DOI 10.4049/jimmunol.1002983 | - |
hcfmusp.relation.reference | Ding Q, 2011, J CLIN INVEST, V121, P3645, DOI 10.1172/JCI46274 | - |
hcfmusp.relation.reference | Dragun D, 2005, NEW ENGL J MED, V352, P558, DOI 10.1056/NEJMoa035717 | - |
hcfmusp.relation.reference | Dunn TB, 2011, AM J TRANSPLANT, V11, P2132, DOI 10.1111/j.1600-6143.2011.03640.x | - |
hcfmusp.relation.reference | Everly MJ, 2008, TRANSPLANTATION, V86, P1754, DOI 10.1097/TP.0b013e318190af83 | - |
hcfmusp.relation.reference | Fehr T, 2009, TRANSPLANTATION, V87, P1837, DOI 10.1097/TP.0b013e3181a6bac5 | - |
hcfmusp.relation.reference | Fillatreau S, 2002, NAT IMMUNOL, V3, P944, DOI 10.1038/ni833 | - |
hcfmusp.relation.reference | Gasser M, 2002, TRANSPLANT P, V34, P2244, DOI 10.1016/S0041-1345(02)03221-9 | - |
hcfmusp.relation.reference | Goers TA, 2008, J IMMUNOL, V180, P4487 | - |
hcfmusp.relation.reference | Graff RJ, 2009, HUM IMMUNOL, V70, P502, DOI 10.1016/j.humimm.2009.04.002 | - |
hcfmusp.relation.reference | Guo HL, 2010, NATURE, V466, P835, DOI 10.1038/nature09267 | - |
hcfmusp.relation.reference | Hagedorn PH, 2010, IMMUNOLOGY, V130, P427, DOI 10.1111/j.1365-2567.2010.03246.x | - |
hcfmusp.relation.reference | Hale G, 1983, Mol Biol Med, V1, P321 | - |
hcfmusp.relation.reference | HALE G, 1990, TISSUE ANTIGENS, V35, P118, DOI 10.1111/j.1399-0039.1990.tb01767.x | - |
hcfmusp.relation.reference | Hanaway MJ, 2011, NEW ENGL J MED, V364, P1909, DOI 10.1056/NEJMoa1009546 | - |
hcfmusp.relation.reference | Harris DP, 2005, J IMMUNOL, V174, P6781 | - |
hcfmusp.relation.reference | Harris DP, 2000, NAT IMMUNOL, V1, P475, DOI 10.1038/82717 | - |
hcfmusp.relation.reference | Hashimoto Y, 2002, BLOOD, V100, P3504, DOI 10.1182/blood-2002-03-0733 | - |
hcfmusp.relation.reference | Heidt S, 2012, AM J TRANSPLANT, V12, P1784, DOI 10.1111/j.1600-6143.2012.04012.x | - |
hcfmusp.relation.reference | Iwata T, 2008, J IMMUNOL, V181, P5738 | - |
hcfmusp.relation.reference | Iwata Y, 2011, BLOOD, V117, P530, DOI 10.1182/blood-2010-07-294249 | - |
hcfmusp.relation.reference | Jindra PT, 2006, TRANSPLANTATION, V82, pS33, DOI 10.1097/01.tp.0000231447.34240.3c | - |
hcfmusp.relation.reference | Jonker M, 2005, TRANSPLANTATION, V80, P385, DOI 10.1097/01.tp.0000166920.18998.15 | - |
hcfmusp.relation.reference | Kamburova EG, 2012, AM J TRANSPLANT, V12, P341, DOI 10.1111/j.1600-6143.2011.03833.x | - |
hcfmusp.relation.reference | Kaneku H, 2012, LIVER TRANSPLANT, V18, P984, DOI 10.1002/lt.23451 | - |
hcfmusp.relation.reference | Kokko KE, 2012, AM J TRANSPLANT, V12, P1077, DOI 10.1111/j.1600-6143.2012.04016.x | - |
hcfmusp.relation.reference | Kweon MN, 1998, J IMMUNOL, V160, P1687 | - |
hcfmusp.relation.reference | Kwun J, 2012, SEMIN IMMUNOL, V24, P96, DOI 10.1016/j.smim.2011.08.022 | - |
hcfmusp.relation.reference | LaMattina JC, 2012, TRANSPL INT, V25, P518, DOI 10.1111/j.1432-2277.2012.01448.x | - |
hcfmusp.relation.reference | Lechler R, 2001, IMMUNITY, V14, P357, DOI 10.1016/S1074-7613(01)00116-9 | - |
hcfmusp.relation.reference | Le Texier L, 2011, AM J TRANSPLANT, V11, P429, DOI 10.1111/j.1600-6143.2010.03336.x | - |
hcfmusp.relation.reference | Linton PJ, 2000, J IMMUNOL, V165, P5558 | - |
hcfmusp.relation.reference | Lund FE, 2010, NAT REV IMMUNOL, V10, P236, DOI 10.1038/nri2729 | - |
hcfmusp.relation.reference | Mackay F, 2002, NAT REV IMMUNOL, V2, P465, DOI 10.1038/nri844 | - |
hcfmusp.relation.reference | Mackay F, 2009, NAT REV IMMUNOL, V9, P491, DOI 10.1038/nri2572 | - |
hcfmusp.relation.reference | Mackay F, 2003, ANNU REV IMMUNOL, V21, P231, DOI 10.1146/annurev.immunol.21.120601.141152 | - |
hcfmusp.relation.reference | Mann MK, 2007, J IMMUNOL, V178, P3447 | - |
hcfmusp.relation.reference | Mauri C, 2003, J EXP MED, V197, P489, DOI 10.1084/jem.20021293 | - |
hcfmusp.relation.reference | Mauri C, 2012, ANNU REV IMMUNOL, V30, P221, DOI 10.1146/annurev-immunol-020711-074934 | - |
hcfmusp.relation.reference | Mauri C, 2010, NAT REV RHEUMATOL, V6, P636, DOI 10.1038/nrrheum.2010.140 | - |
hcfmusp.relation.reference | Meister S, 2007, CANCER RES, V67, P1783, DOI 10.1158/0008-5472.CAN-06-2258 | - |
hcfmusp.relation.reference | Merbl Y, 2007, J CLIN INVEST, V117, P712, DOI 10.1072/JC129943 | - |
hcfmusp.relation.reference | Mizoguchi A, 2006, J IMMUNOL, V176, P705 | - |
hcfmusp.relation.reference | Mizoguchi A, 2002, IMMUNITY, V16, P219, DOI 10.1016/S1074-7613(02)00274-1 | - |
hcfmusp.relation.reference | Moraes-Vieira PMM, 2010, HUM IMMUNOL, V71, P442, DOI 10.1016/j.humimm.2010.01.022 | - |
hcfmusp.relation.reference | Moraes-Vieira PMM, 2012, CLIN IMMUNOL, V142, P117, DOI 10.1016/j.clim.2011.08.015 | - |
hcfmusp.relation.reference | Nath DS, 2011, TRANSPLANTATION, V91, P1036, DOI 10.1097/TP.0b013e318211d2f4 | - |
hcfmusp.relation.reference | Newell KA, 2010, J CLIN INVEST, V120, P1836, DOI 10.1172/JCI39933 | - |
hcfmusp.relation.reference | Newell KA, 2011, CURR OPIN IMMUNOL, V23, P655, DOI 10.1016/j.coi.2011.07.008 | - |
hcfmusp.relation.reference | Noorchashm H, 2006, J IMMUNOL, V177, P7715 | - |
hcfmusp.relation.reference | Obeng EA, 2006, BLOOD, V107, P4907, DOI 10.1182/blood-2005-08-3531 | - |
hcfmusp.relation.reference | Olofsson PS, 2012, IMMUNOL REV, V248, P188, DOI 10.1111/j.1600-065X.2012.01138.x | - |
hcfmusp.relation.reference | Otto C, 2001, TRANSPLANT P, V33, P431, DOI 10.1016/S0041-1345(00)02079-0 | - |
hcfmusp.relation.reference | Pallier A, 2010, KIDNEY INT, V78, P503, DOI 10.1038/ki.2010.162 | - |
hcfmusp.relation.reference | Parsons RF, 2012, TRANSPLANTATION, V93, P676, DOI 10.1097/TP.0b013e318246621d | - |
hcfmusp.relation.reference | PIERCE SK, 1988, IMMUNOL REV, V106, P149, DOI 10.1111/j.1600-065X.1988.tb00778.x | - |
hcfmusp.relation.reference | Porcheray F, 2010, TRANSPLANTATION, V89, P1239, DOI 10.1097/TP.0b013e3181d72091 | - |
hcfmusp.relation.reference | Portugal K, 2001, INT IMMUNOL, V13, P747, DOI 10.1093/intimm/13.6.747 | - |
hcfmusp.relation.reference | Qin ZQ, 2011, TRANSPLANTATION, V92, P829, DOI 10.1097/TP.0b013e31822d0977 | - |
hcfmusp.relation.reference | Quintana FJ, 2006, LUPUS, V15, P428, DOI 10.1191/0961203306lu2328oa | - |
hcfmusp.relation.reference | Redfield RR, 2011, CURR OPIN IMMUNOL, V23, P685, DOI 10.1016/j.coi.2011.07.011 | - |
hcfmusp.relation.reference | Riewaldt Julia, 2012, Front Immunol, V3, P141, DOI 10.3389/fimmu.2012.00141 | - |
hcfmusp.relation.reference | Rogers NJ, 2001, AM J TRANSPLANT, V1, P97, DOI 10.1034/j.1600-6143.2001.10201.x | - |
hcfmusp.relation.reference | Rowe V, 2006, BLOOD, V108, P2485, DOI 10.1182/blood-2006-04-016063 | - |
hcfmusp.relation.reference | Sagoo P, 2010, J CLIN INVEST, V120, P1848, DOI 10.1172/JCI39922 | - |
hcfmusp.relation.reference | Silva HM, 2012, MOL MED, V18, P733, DOI 10.2119/molmed.2011.00281 | - |
hcfmusp.relation.reference | Spadafora-Ferreira M, 2007, SCAND J IMMUNOL, V66, P352, DOI 10.1111/j.1365-3083.2007.01976.x | - |
hcfmusp.relation.reference | Stastny P, 2009, HUM IMMUNOL, V70, P600, DOI 10.1016/j.humimm.2009.04.017 | - |
hcfmusp.relation.reference | Sun QQ, 2005, TRANSPLANTATION, V79, P1759, DOI 10.1097/01.TP.0000163290.19788.E7 | - |
hcfmusp.relation.reference | Sun QQ, 2011, KIDNEY INT, V79, P655, DOI 10.1038/ki.2010.437 | - |
hcfmusp.relation.reference | Sun QQ, 2008, CLIN J AM SOC NEPHRO, V3, P1479, DOI 10.2215/CJN.04451007 | - |
hcfmusp.relation.reference | SWAIN SL, 1987, IMMUNOL REV, V99, P263, DOI 10.1111/j.1600-065X.1987.tb01180.x | - |
hcfmusp.relation.reference | Thaunat O, 2011, TRANSPLANTATION, V92, P121, DOI 10.1097/TP.0b013e31821f74fe | - |
hcfmusp.relation.reference | Thaunat O, 2012, KIDNEY INT, V81, P207, DOI 10.1038/ki.2011.317 | - |
hcfmusp.relation.reference | Thaunat O, 2010, J IMMUNOL, V185, P717, DOI 10.4049/jimmunol.0903589 | - |
hcfmusp.relation.reference | Thibault-Espitia A, 2012, AM J TRANSPLANT, V12, P2754, DOI 10.1111/j.1600-6143.2012.04194.x | - |
hcfmusp.relation.reference | Thiyagarajan UM, 2012, TRANSPL P, V44, P1231, DOI 10.1016/j.transproceed.2011.10.054 | - |
hcfmusp.relation.reference | Trivedi HL, 2009, TRANSPLANTATION, V87, P1555, DOI 10.1097/TP.0b013e3181a4b91b | - |
hcfmusp.relation.reference | Tsang JYS, 2009, TRANSPL IMMUNOL, V21, P203, DOI 10.1016/j.trim.2009.05.003 | - |
hcfmusp.relation.reference | Tsang JYS, 2008, J CLIN INVEST, V118, P3619, DOI 10.1172/JCI33185 | - |
hcfmusp.relation.reference | Tyden G, 2009, TRANSPLANTATION, V87, P1325, DOI 10.1097/TP.0b013e3181a235fd | - |
hcfmusp.relation.reference | UCKUN FM, 1990, BLOOD, V76, P1908 | - |
hcfmusp.relation.reference | Venetz JP, 2007, EXPERT OPIN INV DRUG, V16, P625, DOI 10.1517/13543784.16.5.625 | - |
hcfmusp.relation.reference | Waldmann H, 2006, IMMUNOL REV, V212, P301, DOI 10.1111/j.0105-2896.2006.00406.x | - |
hcfmusp.relation.reference | Walsh RC, 2010, TRANSPLANTATION, V89, P277, DOI 10.1097/TP.0b013e3181c6ff8d | - |
hcfmusp.relation.reference | Walsh RC, 2012, KIDNEY INT, V81, P1067, DOI 10.1038/ki.2011.502 | - |
hcfmusp.relation.reference | Walters S, 2009, J IMMUNOL, V182, P793 | - |
hcfmusp.relation.reference | Wiebe C, 2012, AM J TRANSPLANT, V12, P1157, DOI 10.1111/j.1600-6143.2012.04013.x | - |
hcfmusp.relation.reference | Wilkes DS, 2012, SEMIN IMMUNOL, V24, P131, DOI 10.1016/j.smim.2011.08.020 | - |
hcfmusp.relation.reference | Wolf SD, 1996, J EXP MED, V184, P2271, DOI 10.1084/jem.184.6.2271 | - |
hcfmusp.relation.reference | Morrow WR, 2012, TRANSPLANTATION, V93, P319, DOI 10.1097/TP.0b013e31823f7eea | - |
hcfmusp.relation.reference | Yanaba K, 2008, IMMUNITY, V28, P639, DOI 10.1016/j.immuni.2008.03.017 | - |
hcfmusp.relation.reference | Zarkhin V, 2010, TRANSPLANT REV-ORLAN, V24, P67, DOI 10.1016/j.trre.2010.01.004 | - |
hcfmusp.relation.reference | Zhou L, 2009, IMMUNITY, V30, P646, DOI 10.1016/j.immuni.2009.05.001 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.remissive.sponsorship | INCTs | - |
hcfmusp.citation.scopus | 19 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/19 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_COELHO_Rethinking_the_multiple_roles_of_B_cells_in_2013.PDF Restricted Access | publishedVersion (English) | 283.88 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.